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A unique wall-breaking preparation

A unique and preparation technology, applied in the field of traditional Chinese medicine, can solve the problems of loss of active ingredients, poor thermal stability, easy to absorb moisture, etc., and achieve the effects of being easy to drink with warm water, strong stability of the finished product, and easy to disintegrate and disperse.

Active Publication Date: 2018-03-16
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relatively sensitive to temperature, poor thermal stability
Therefore, if the traditional decocting method is adopted, on the one hand, it is easy to destroy its active ingredients, and on the other hand, the incomplete decoction of the ingredients will cause the loss of active ingredients.
The preparation of Duyiwei into Duyiwei superfine powder is beneficial to improve the utilization rate of active ingredients, but at the same time, due to the increase of the specific surface area of ​​the powder, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take Duyiwei pure medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 38 μm, add ethanol-water solution (the mass fraction of ethanol is 30%) soft material by wet method, the ratio of solution to superfine powder is 0.5︰1 (by weight), after mixing, it is pre-installed with a 10-mesh sieve, and the extrusion speed is 50r / min, and the extrusion force is 1MPa. Wet granules, wet granules are placed in a hot air circulation oven, set the drying temperature at 85°C, and dry for 2.5 hours until dry.

[0025]

[0026] Note: The full score is 10.

Embodiment 2

[0028] Take Duyiwei pure medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 38 μm, add ethanol-water solution (the mass fraction of ethanol is 40%) soft material by wet method, the ratio of solution to superfine powder is 0.6︰1 (by weight), after mixing, pre-installed with a 10-mesh sieve, the extrusion speed is 55r / min, and the extrusion force is 0.9MPa Wet granules are made, and the wet granules are transferred to a vacuum microwave drying oven, set the drying temperature to 45°C, and dried for 0.75h until dry.

[0029]

[0030] Note: The full score is 10.

Embodiment 3

[0032] Take Duyiwei pure medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 38 μm, add ethanol-water solution (the mass fraction of ethanol is 50%) soft material by wet method, the ratio of solution to superfine powder is 0.7︰1 (by weight), after mixing, pre-installed with a 30-mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa Wet granules are made, and the wet granules are placed in a hot air circulation oven, set the drying temperature at 85°C, and dried for 2.5 hours until dry.

[0033]

[0034] Note: The full score is 10.

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Abstract

The invention relates to a traditional Chinese medicine preparation, in particular to a unique wall-breaking preparation. According to the invention, by pulverizing Duyiwei into ultra-fine powder, further granulating through ethanol-water wet method, extruding and drying at a certain speed, the prepared Duyiwei broken wall preparation has high bioavailability rate, and the preparation has strong stability and good disintegration.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, and more specifically, to a unique wall-breaking preparation. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the efficacy. However, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K36/53A61K9/16A61J3/00
Inventor 成金乐陈勇军钱锦花徐吉银劳悦富
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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