Metal micro-needle array with medicine grooves and micro-needle percutaneous dosing patch and device

Abstract

The invention discloses a metal micro-needle array with medicine grooves and a micro-needle percutaneous dosing patch and device. The metal micro-needle array comprises a substrate and a plurality of metal micro-needles. The metal micro-needles are arranged on the substrate at intervals and are made from metal tubes, the medicine grooves are formed by inner cavities of the metal tubes, and part of the metal tubes are removed in the axial direction of the metal tubes, so that the medicine grooves are provided with radial openings facing the metal tubes. According to the metal micro-needle array with the medicine grooves, part of the metal tubes are removed in the axial direction of the metal tubes, so that the metal micro-needles are formed, the sizes of the metal micro-needles are reduced, pain of a user is low in the using process, no blood flows out, and minimally-invasive skin can be quickly self-healed after the metal micro-needle array is used; meanwhile, the medicine grooves with the radial openings serve as medicine storehouses, detection of the filling effect and filling operation of medicine are facilitated, and the probability that medicine is left out of the body in the needle applying process can be greatly decreased.

Description

technical field [0001] The invention relates to the technical fields of medicine, medical treatment and beauty equipment, in particular to a metal microneedle array with a medicine groove, a microneedle transdermal drug delivery patch and a device. Background technique [0002] Metal microneedle arrays have a very wide range of applications in the fields of transdermal drug delivery, cosmetics, and tattoos. Because of the barrier function of the outermost stratum corneum of the skin, the transdermal permeability of most drugs is very low and it is difficult to achieve the expected curative effect. The use of short and sharp metal microneedle arrays by pressing needles can instantly create many micron-sized pores in the stratum corneum and epidermis of the skin, so it can greatly improve the transdermal penetration of drugs and cosmetic skin care products, thus significantly Improve the efficacy and beauty effect. There are two types of microneedles: solid needles and hollo...

AI Technical Summary

Problems solved by technology

The problem with the first method is that it is difficult to control the actual drug dose; the problem with the second method is that it is difficult to apply a sufficient amount of medicament on the needle tip and effectively prevent the drug from penetrating into the skin. was shed out

Although the pores of the hollow microneedle needles can be used as drug storage tanks to effectively solve the above problems, there are also problems such as large needle size, and it is difficult to fill quantitative medicine into the many tiny holes of the microneedle array uniformly due to the influence of factors such as gas in the pores. The problem of in-channel and difficult detection of actual filling dose

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