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Copper complex for treating dermatophytosis, and preparation and preparation method thereof

A copper complex and the technology of the complex are applied in the field of preparation of copper complexes and their preparations for the treatment of athlete's foot, which can solve the problems of high recurrence rate and poor curative effect, and achieve low toxic and side effects, reduced toxicity, and high clinical efficacy. significant effect

Inactive Publication Date: 2014-11-05
吕晓芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The main cause of tinea pedis and tinea manuum is fungal infection. There are many anti-fungal drugs at present. After long-term use, many fungi will develop drug resistance, poor curative effect and high recurrence rate.
[0003] Existing data and clinical evidence show that the traditional Chinese medicine aeruginosa is an anti-fungal traditional Chinese medicine for treating stubborn tinea, but green copper itself is toxic, and it will produce certain side effects after external use, such as: rash, tingling, redness, etc. on the skin. Therefore, It is necessary to use the beneficial effects of aeruginosa to develop curative and safe topical medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A copper complex consisting of 50% verdigris and 50% aspirin by weight.

[0016] The preparation method of above-mentioned copper complex, comprises the following steps:

[0017] A. take each raw material by weight percentage for subsequent use;

[0018] B. Adding pure water to dissolve the verdigris into a saturated verdigris solution;

[0019] C. Aspirin crystals are dissolved in 95% ethanol to form a saturated aspirin solution;

[0020] D. Pour the aspirin solution into the verdigris solution, stir, and dark blue crystals gradually form. This process takes several hours; when the color of the liquid turns blue, and no new blue crystals are formed, the reaction reaches a network point; cool at a temperature below 5 degrees Celsius and extract the blue crystals; wash the blue crystals with cold distilled water, and dry the blue crystals at 50 degrees Celsius to obtain a copper complex; store the copper complex in In a dark bottle.

Embodiment 2

[0022] A copper complex consisting of 28% verdigris and 72% aspirin by weight.

[0023] The preparation method of above-mentioned copper complex, comprises the following steps:

[0024] A. take each raw material by weight percentage for subsequent use;

[0025] B. Adding pure water to dissolve the verdigris into a saturated verdigris solution;

[0026] C. Aspirin crystals are dissolved in 95% ethanol to form a saturated aspirin solution;

[0027] D. Pour the aspirin solution into the verdigris solution, stir, and dark blue crystals gradually form. This process takes several hours; when the color of the liquid turns blue, and no new blue crystals are formed, the reaction reaches a network point; cool at a temperature below 5 degrees Celsius and extract the blue crystals; wash the blue crystals with cold distilled water, and dry the blue crystals at 50 degrees Celsius to obtain a copper complex; store the copper complex in In a dark bottle.

Embodiment 3

[0029] A copper complex consisting of 70% verdigris and 30% aspirin by weight.

[0030] The preparation method of above-mentioned copper complex, comprises the following steps:

[0031] A. take each raw material by weight percentage for subsequent use;

[0032] B. Adding pure water to dissolve the verdigris into a saturated verdigris solution;

[0033] C. Aspirin crystals are dissolved in 95% ethanol to form a saturated aspirin solution;

[0034] D. Pour the aspirin solution into the verdigris solution, stir, and dark blue crystals gradually form. This process takes several hours; when the color of the liquid turns blue, and no new blue crystals are formed, the reaction reaches a network point; cool at a temperature below 5 degrees Celsius and extract the blue crystals; wash the blue crystals with cold distilled water, and dry the blue crystals at 50 degrees Celsius to obtain a copper complex; store the copper complex in In a dark bottle.

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Abstract

The invention discloses a copper complex for treating dermatophytosis, and a preparation and a preparation method thereof. The complex comprises the following raw materials by weight percent: 20-80% of verdigris and 20-80% of aspirin. The method comprises the following steps: adding verdigris to purified water, and adding aspirin crystal to 95% ethanol; respectively dissolving the verdigris and the aspirin crystal to obtain saturated solutions, and mixing the saturated solutions to generate blue crystal; adding a solvent or an emulsifier, so as to prepare into the preparations such as a soaking aqueous solution, an inunction aqueous solution and an inunction ointment. According to the preparations of the complex, the toxicity of the verdigris is reduced when the curative effects on resisting fungi and treating stubborn dermatitis of the verdigris are improved, and the copper complex is small in toxic and side effects. A few of dosage forms are externally applied to treatment of common fungal infection skin diseases such as dermatophytosis, tinea manuum, foot odor and tinea corporis, so that the clinical effect is significant.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a copper complex for treating athlete's foot, a preparation and a preparation method thereof. Background technique [0002] The main cause of disease of athlete's foot, tinea manuum is fungal infection, and the medicine of antifungal is a lot at present, uses for a long time, and many molds produce drug resistance, curative effect is poor, and recurrence rate is high. [0003] Existing data and clinical evidence show that the traditional Chinese medicine aeruginosa is an anti-fungal traditional Chinese medicine for treating stubborn tinea, but green copper itself is toxic, and it will produce certain side effects after external use, such as: rash, tingling, redness, etc. on the skin. Therefore, It is necessary to utilize the beneficial effects of aeruginosa to develop curative and safe topical medicines. Contents of the invention [0004] The object of the present invention is to provide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/34A61K9/06A61K9/00A61P17/00A61P31/10A61K31/616
Inventor 吕晓芳
Owner 吕晓芳
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