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Pharmaceutical composition for treating chloasma and preparation method thereof

A composition and technology of chloasma, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of unsatisfactory treatment effect, toxic and side effects, etc., and achieve the reduction of lipid peroxidation and the curative effect Definitely, the effect of reducing the production of melanin

Active Publication Date: 2014-12-03
BEIJING UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no specific medicine for treating chloasma with Western medicine. The main treatments include drug therapy, physical therapy, chemotherapy, etc. The therapeutic effect is not ideal, and there are certain toxic and side effects

Method used

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  • Pharmaceutical composition for treating chloasma and preparation method thereof
  • Pharmaceutical composition for treating chloasma and preparation method thereof
  • Pharmaceutical composition for treating chloasma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The raw materials were weighed according to the following proportions: 50 parts of Ligustrum lucidum, 50 parts of Eclipta chinensis, 80 parts of Salvia miltiorrhiza, 70 parts of angelica, 15 parts of cinnamon, 15 parts of rose, and 5 parts of grape seed extract.

[0064] Preparation method: according to the above-mentioned raw materials and weight ratio of the traditional Chinese medicine composition, the medicinal materials are respectively taken, firstly add Ligustrum lucidum, eclipta, salvia miltiorrhiza, angelica, cinnamon, and roses into the extraction tank, soak for 30 minutes for the first time, add Decoct 10 times the amount of water twice, each time for 1.5h, filter, and combine the filtrates; add 70% ethanol, precipitate, and obtain a supernatant, which is concentrated under reduced pressure (70°C, 0.08Mpa) to a relative density of 1.08 ~1.10 (60°C), recover ethanol to obtain extract, then vacuum dry (70°C, 0.08Mpa), pulverize, and pass through a 60-mesh sieve ...

Embodiment 2

[0066] The raw materials were weighed according to the following proportions: 10 parts of Ligustrum lucidum, 10 parts of Eclipta chinensis, 30 parts of Salvia miltiorrhiza, 20 parts of angelica, 5 parts of cinnamon, 5 parts of rose, and 0.1 part of grape seed extract.

[0067] Preparation method: according to the above-mentioned raw materials and weight ratio of the traditional Chinese medicine composition, the medicinal materials are respectively taken, firstly add Ligustrum lucidum, eclipta, salvia miltiorrhiza, angelica, cinnamon, and roses into the extraction tank, soak for 30 minutes for the first time, add Decoct 10 times the amount of water twice, each time for 1.5h, filter, and combine the filtrates; add 70% ethanol, precipitate, and obtain a supernatant, which is concentrated under reduced pressure (70°C, 0.08Mpa) to a relative density of 1.08 ~1.10 (60°C), recover ethanol to obtain extract, then vacuum dry (70°C, 0.08Mpa), pulverize, and pass through a 60-mesh sieve t...

Embodiment 3

[0069] The raw materials were weighed according to the following proportions: 30 parts of Ligustrum lucidum, 30 parts of Eclipta chinensis, 60 parts of Salvia miltiorrhiza, 40 parts of angelica, 10 parts of cinnamon, 10 parts of rose, and 2 parts of grape seed extract.

[0070]Preparation method: according to the above-mentioned raw materials and weight ratio of the traditional Chinese medicine composition, the medicinal materials are respectively taken, firstly add Ligustrum lucidum, eclipta, salvia miltiorrhiza, angelica, cinnamon, and roses into the extraction tank, soak for 30 minutes for the first time, add Decoct 10 times the amount of water twice, each time for 1.5h, filter, and combine the filtrates; add 70% ethanol, precipitate, and obtain a supernatant, which is concentrated under reduced pressure (70°C, 0.08Mpa) to a relative density of 1.08 ~1.10 (60°C), recover ethanol to obtain extract, then vacuum dry (70°C, 0.08Mpa), pulverize, and pass through a 60-mesh sieve t...

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Abstract

The invention relates to a pharmaceutical composition for treating chloasma and a preparation method thereof. The pharmaceutical composition is mainly prepared from fructus ligustri lucidi, herba ecliptae, radix salviae miltiorrhizae, angelica sinensis, cinnamomum cassia, rose and a grape seed extract. The pharmaceutical composition has the efficacies of nourishing liver and kidney, removing blood stasis and eliminating spots, and is suitable for patients with chloasma. Clinical studies show that the pharmaceutical composition can obviously improve symptoms of the patients with melasma, has the clinical total effective rate of 91.43% and has no toxic or side effect; and experimental studies show that the pharmaceutical composition can obviously reduce the chloasma mouse whole blood viscosity, improves the blood consistence, increases the activity of free radical scavenging enzymes, decreases lipid peroxidation, and reduces the formation of melanin.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition for treating chloasma and a preparation method thereof. 2. Background technology [0002] Chloasma is a common pigmented skin disease that occurs mostly in women of childbearing age. It is a stubborn condition that seriously affects the appearance of patients and brings a lot of trouble and pain to their spirit and life. According to statistics by foreign scholars, the incidence rate ranges from 30% to 70%, while in our country, the incidence rate is about 30%. Upward trend. [0003] The pathogenesis of chloasma is very complicated, and the cause of the disease is still not very clear. Modern medicine believes that it is mainly related to factors such as endocrine disorders, pregnancy, genetic factors, oxygen free radicals, and ultraviolet radiation. Western medicine treatment of chloasma does not have specific medicine yet, mainly contains drug therapy, physical therapy, chemotherapy etc. in ...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P17/00
Inventor 刘铜华
Owner BEIJING UNIV OF CHINESE MEDICINE
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