A kind of patch, coating equipment for preparing patch and preparation method thereof

A patch and coating technology, which is applied in medical science, injection devices, prostheses, etc., can solve the problems of material convergence, patch surface roughness, and influence on coating uniformity, so as to avoid coatings that are too thick or too thin , The surface of the patch is smooth and uniform, and the effect of solving the uneven coating

Active Publication Date: 2016-07-20
ACCUPATH MEDICAL JIAXING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When dipping and brushing are used to coat biological materials, the thickness and uniformity of the coating cannot be controlled, the controllability is poor, and the surface roughness of the coating is large
Although the spraying method can reduce the phenomenon of aggregation and condensation into droplets, there are still shortcomings in the traditional spraying method. First, the phenomenon of material aggregation is prone to occur, and the surface of the patch is rough; The solution accumulated on the patch seriously affects the uniformity of the coating. There are often a large number of spraying blind spots, and the area not covered by the coating reaches more than 20%. Moreover, when the coated biological material is removed, the biological material is easy to be tearing, resulting in waste and increased costs

Method used

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  • A kind of patch, coating equipment for preparing patch and preparation method thereof
  • A kind of patch, coating equipment for preparing patch and preparation method thereof
  • A kind of patch, coating equipment for preparing patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The polypropylene patch material was washed with 1% Triton and deionized water by ultrasonic vibration for 15 minutes, dried and set aside. Mix the two together according to the ratio of fish oil:cross-linking agent=100:21, react at 100°C for 40 hours to obtain a coating solution, take out the coating solution, and set aside. Fill the coating solution into the syringe in the fume hood, adjust the injection rate of the coating solution in the syringe to 0.08ml / min and the compressed gas pressure to 8psi; fix the patch material on the polytetrafluoroethylene fixture, and use Figure 2 Clamped by the supportable fixture in (a), adjust the distance between the nozzle 14 and the fixture 2 to be 30cm; adjust the number of reciprocating movements of the movable nozzle to 15 times, start the spraying process, and the coating solution is sprayed onto the patch material through the movable nozzle surface to form a patch; remove the patch from the polytetrafluoroethylene fixture, p...

Embodiment 2

[0047] The bare polyester patch material with a size of 10cm×10cm was washed with 3% Triton and deionized water by ultrasonic vibration for 20 minutes, dried and set aside. Mix the two together according to the ratio of fish oil:cross-linking agent=100:15, react at 90°C for 60h, take out the coating solution, and set aside. Fill the coating solution into the syringe in the fume hood, adjust the injection rate of the coating solution in the syringe to 0.01ml / min and the compressed gas pressure to 3psi; fix the patch material on the polyvinylidene chloride fixture, and use Figure 2 Clamped by the supportable fixture in (b), adjust the distance between the nozzle 14 and the fixture 2 to be 10cm; adjust the number of reciprocating movements of the movable nozzle to be 20 times, start the spraying process, and the coating solution is sprayed to the patch material through the movable nozzle surface to form a patch; remove the patch from the polyvinylidene chloride fixture, put it in...

Embodiment 3

[0049] The expanded polytetrafluoroethylene patch material was washed with 1% Triton and deionized water by ultrasonic vibration for 15 minutes, dried and set aside. Mix the two together according to the ratio of fish oil:cross-linking agent=100:30, react at 110°C for 48 hours, take out the coating solution, and set aside. In the fume hood, the coating solution is poured into the syringe, and the injection speed of the coating solution in the syringe is adjusted to be 0.008ml / min and the compressed gas pressure is 5psi; Clamped by the supportable fixture in 2(c), the distance between the nozzle 14 and the fixture 2 is adjusted to be 20cm; the number of reciprocating movements of the movable nozzle is adjusted to 30 times, and the spraying process is started, and the coating solution is sprayed to the patch via the movable nozzle A patch is formed on the surface of the material; the patch is removed from the polytetrafluoroethylene plate, placed in an oven, and dried at 70° C. ...

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Abstract

The invention discloses a patch, a coating device used for manufacturing the patch and a manufacturing method of the patch. The coating device comprises a patch material fixing device, a spray head and a spray head moving device. The spray head moving device comprises a first moving device body and a second moving device body connected with the first moving device body, the first moving device body is used for controlling the spray head to move in the first direction, and the second moving device body is used for controlling the spray head to move in the second direction. According to the coating device used for manufacturing the composite patch and the manufacturing method of the patch, in the spraying process, the moving trails of the spray head can be freely adjusted, and therefore an even coating effect is achieved; the thickness of a coating of the composite patch is adjustable, and the problem that the coating is excessively thick or thin in the production process is avoided; the surface of the manufactured composite patch is smooth and even, the hand feeling of the composite patch after coating is improved, and an implanting operation is facilitated for a doctor.

Description

technical field [0001] The invention belongs to the field of biomedical material processing, and in particular relates to a patch, coating equipment for preparing the patch and a preparation method thereof. Background technique [0002] Biological patch is the regeneration system of human beings in the new century, which can promote the repair function of the human body to complete the regeneration of new tissues. After the biological patch is implanted into the human body, it plays a very good supporting role and fills the missing tissue in the damaged part. Under the induction of the material, the human body's own repair function can gradually grow new tissue in the original position, replacing the biological patch. materials to complete the process of organ tissue regeneration. [0003] At the present stage, artificially synthesized polymer material patches are commonly used clinically. However, these polymer material patches are mostly non-absorbable materials, which ar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B05B13/04B05B13/02A61F2/02
CPCA61F2/02B05B13/0264B05B13/0271B05B13/0292B05B13/041
Inventor 杜广武陈大凯罗七一
Owner ACCUPATH MEDICAL JIAXING CO LTD
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