Vitamin E nano-microemulsion and preparation method thereof

A nano-microemulsion and vitamin technology, applied in the field of microemulsion, can solve the problems of many solvents, low solubility, low vitamin E, etc., and achieve the effect of increasing the concentration and improving the application

Active Publication Date: 2014-12-17
SHANDONG HAINENG BIOENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical problem to be solved: vitamin E is a functional factor that needs to be supplemented in the human body, but vitamin E is an oil-soluble component, and its solubility with water is very low, so it needs to be improved t

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of vitamin E nano microemulsion, comprising the following steps:

[0034] (1) Take 10g of vitamin E, 12g of Tween-65, 8g of sodium stearoyl lactylate, and 3g of Sipan 80, heat and dissolve vitamin E, Tween-65, sodium stearoyl lactylate, and Sipan 80, and heat The temperature is 50°C. After dissolving, use a vortex oscillator for vortex oscillation, and oscillate until the three raw materials are mixed evenly, and it is A liquid;

[0035] (2) Take another 9g of propylene glycol and dissolve it in 58g of water, mix the propylene glycol and water evenly, and make B liquid;

[0036] (3) Mix liquid A and liquid B, and then perform vortex oscillation after mixing. The vortex oscillation time is 10 minutes. After the oscillation is completed, vitamin E nano-microemulsion is prepared.

[0037] The average particle diameter of the vitamin E nanomicroemulsion in Example 1 is 73nm, and the encapsulation efficiency is 89%.

Embodiment 2

[0039] A preparation method of vitamin E nano microemulsion, comprising the following steps:

[0040] (1) Take 15g of vitamin E, 15g of Tween-65, 6g of sodium stearoyl lactylate, and 4g of Span 80, heat and dissolve vitamin E, Tween-65, sodium stearoyl lactylate, and Span 80, and heat The temperature is 50°C. After dissolving, use a vortex oscillator for vortex oscillation, and oscillate until the three raw materials are mixed evenly, and it is A liquid;

[0041] (2) Another 7g of propylene glycol was dissolved in 53g of water, and the propylene glycol and water were mixed evenly to obtain liquid B;

[0042] (3) Mix liquid A and liquid B, and then perform vortex oscillation after mixing. The vortex oscillation time is 10 minutes. After the oscillation is completed, vitamin E nano-microemulsion is prepared.

[0043] The average particle diameter of the vitamin E nanomicroemulsion in Example 2 is 84nm, and the encapsulation efficiency is 84%.

Embodiment 3

[0045] A preparation method of vitamin E nano microemulsion, comprising the following steps:

[0046] (1) Take 5g of vitamin E, 10g of Tween-65, 12g of sodium stearoyl lactylate, and 5g of Siban 80, heat and dissolve vitamin E, Tween-65, sodium stearoyl lactylate, and Siban 80, and heat The temperature is 50°C. After dissolving, use a vortex oscillator for vortex oscillation, and oscillate until the three raw materials are mixed evenly, and it is A liquid;

[0047] (2) Take another 4g of propylene glycol and dissolve it in 64g of water, and mix the propylene glycol and water evenly to obtain liquid B;

[0048] (3) Mix liquid A and liquid B, and then perform vortex oscillation after mixing. The vortex oscillation time is 10 minutes. After the oscillation is completed, vitamin E nano-microemulsion is prepared.

[0049] The average particle diameter of the vitamin E nanomicroemulsion in Example 3 is 91nm, and the encapsulation efficiency is 85%.

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Abstract

The invention belongs to the field of nano-microemulsions, and discloses a vitamin E nano-microemulsion. The vitamin E nano-microemulsion comprises the following components: 5wt%-15wt% of vitamin E, 10wt%-15wt% of Tween-65, 6wt%-12wt% of sodium stearyl lactate, 3wt%-5wt% of Span-80, 4wt%-9wt% of propylene glycol and the balance being water. A preparation method of the vitamin E nano-microemulsion comprises the processes of mixing and implementing vortex oscillation. The prepared vitamin E nano-microemulsion has the characteristics of high content of active ingredients, small grain size, high encapsulation efficiency and the like.

Description

technical field [0001] The invention belongs to the field of microemulsions, and relates to a nano-microemulsion and a preparation method thereof, in particular to a nano-microemulsion of vitamin E and a method thereof. Background technique [0002] Microemulsion is a thermodynamically stable, isotropic and transparent dispersion system formed by two immiscible liquids under the action of surfactant molecules. Microemulsion is a highly dispersed low-tension system composed of distilled water, oil, surfactant, co-surfactant, etc. in a certain proportion. Any change in the nature or quantity of any component in the components will affect the formation of microemulsion with nature. The selection of surfactant is the core of preparing microemulsion, commonly used surfactant is as follows: sodium dodecylbenzenesulfonate, sodium lauryl sulfate, nonionic surfactant such as Triton X-100 (nonylphenol Polyoxyethylene ether), Npn (nonylbenzene polyoxyethylene ether surfactant), Tween...

Claims

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Application Information

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IPC IPC(8): A23L1/302A23P1/10A23L33/15A23P10/00A23P30/00
CPCA23L33/00A23L33/15A23V2002/00A23V2250/712
Inventor 张小英
Owner SHANDONG HAINENG BIOENG CO LTD
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