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A new type of sea urchin endogenous oxytocic agent that is safe, efficient and non-toxic

A non-toxic, oxytocic agent technology, applied in the direction of diseases, drug combinations, etc., can solve the problems of difficult storage of bile, family building obstacles, and inability to guarantee the efficiency of oxytocin, and achieve efficient sea urchin oxytocin operation, ensuring efficiency and reliability. Effect

Active Publication Date: 2016-04-27
DALIAN OCEAN UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

But also has its fatal shortcoming, because KCL can cause osmotic pressure disturbance in the sea urchin body, has very big toxicity to sea urchin, can cause very high mortality rate, thereby brings difficulty to the preservation of kind urchin, also provides for backcross, Family building such as test cross brings great obstacles
However, simply reducing the concentration of KCL and the amount of injection cannot guarantee the efficiency of induced labor.

Method used

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Experimental program
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Embodiment Construction

[0008] Specific embodiments of the present invention will be described below. A safe, efficient and non-toxic new sea urchin endogenous oxytocic agent, formulated in the following way:

[0009] First, take 5-peptide amide NFFFFamid (Asn-Gly-Phe-Phe-Phe-amid) powder, dissolve it with ddH2O into 1mM mother solution, which can be stored at -80°C for a long time, and then filter and sterilize the seawater Dilute the mother solution to 10pM to obtain the oxytocic agent.

[0010] Among the Ezo horse dung sea urchin families raised in the laboratory, select a family that has matured gonads through anatomical verification, and randomly select 65 Ezo horse dung sea urchin individuals with similar individual size, about 60 grams, and randomly divide them into 3 groups. Group. The 5 individuals in the first group were used as the blank control group; the 15 individuals in the second group were used as the traditional oxytocic control group and injected; the 45 individuals in the third ...

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Abstract

The invention discloses a novel safe and efficient sea urchin endogenous oxytocic without toxicity and harm. The endogenous oxytocic is characterized by being prepared in the following ways: firstly preparing NGFFF amid powder and dissolving the NGFFF amid powder in ddH2O to obtain 1mM of mother liquor, wherein the mother liquor can be preserved at -80 DEG C for a long time; and then, diluting the mother liquor to 10pM by using filtered and disinfected seawater to obtain the oxytocic. The oxytocic is safe and efficient, and free of any toxicity to sea urchin; in addition, the oxytocic efficiency of the sea urchin endogenous oxytocic is high up to 100%.

Description

technical field [0001] The invention relates to an oxytocic agent, in particular to a new type of sea urchin endogenous oxytocic agent which is safe, efficient and non-toxic. Background technique [0002] The artificial breeding technology of sea urchins and sea cucumbers has matured as early as the 1980s. Among them, the technology of oxytocin adopts the method of drying in the shade, running water or placing them in seawater treated with ultraviolet rays. These traditional methods can basically meet the needs of production. However, there are obvious defects in this simple method of physical stimulation of labor induction, such as low efficiency of labor induction, instability and so on. In recent years, aquatic animal breeding has flourished. Breeding strategies such as BLUP and MAS have greatly improved the breeding efficiency of aquatic animals. However, scientific and efficient breeding strategies first require efficient family construction and germplasm preservatio...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61P15/04
Inventor 常亚青庞震国张伟杰宋坚赵帅
Owner DALIAN OCEAN UNIV