Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same

A 15-OHEPA, 15-hetre technology, which can be used in drug combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., and can solve problems such as dose intensity limitation and bacteria reduction.

Inactive Publication Date: 2014-12-24
DIGNITY SCI
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such creams are not always effective in reducing bacterial growth and improving the clinical manifestations of the condition
Additionally, current regimens are limited in dose strength due to side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same
  • Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same
  • Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Example 1: Effect of different compounds on the growth of P. acnes

[0127] Several compounds, including fatty acids such as DGLA, 15-OHEPA, and 15-HETrE, were tested to determine their ability to inhibit the growth of P. acnes. In one exemplary method, the minimum inhibitory concentration (MIC) of each test compound is determined using the agar dilution method. Briefly, the agar dilution method involves preparing each compound (e.g., nicotinamide, A range of concentrations of benzoyl peroxide, adapalene, metronidazole, DGLA, 15-OHEPA, and 15-HETrE). The P. acnes inoculum was prepared by incubating P. acnes at 35-37° C. for approximately 7 days to achieve a P. acnes inoculum > 1.0 OD600 in RCM broth. A portion of this inoculum was then added as a 10 μL spot to the surface of each plate and incubated at 35-37° C. for 72 hours or more. The growth of P. acnes was then observed and compared to a control plate to which no compound was added and a positive inhibition pla...

Embodiment 2

[0134] Example 2: Effect of Fatty Acid Compounds in Combination with Other Compounds on the Growth of P. acnes ring

[0135] The compounds tested individually in Example 1 were tested in combination with each other to determine the ability of the combination to inhibit the growth of P. acnes. In one exemplary method, for each combination described in Example 1, the MIC was determined. Briefly, the test combination included DGLA + niacinamide, benzoyl peroxide, adapalene, or metronidazole; 15-HETrE + niacinamide, benzoyl peroxide, adapalene, or metronidazole; and 15-OHEPA + Niacinamide, benzoyl peroxide, adapalene, or metronidazole. The table below shows: P. acnes growth in the presence of 0.4 or 1.0 mg / mL DGLA + different concentrations of nicotinamide, benzoyl peroxide, adapalene or metronidazole (Table 3); acnes growth in the presence of 0.05mg / mL 15-HETrE+ different concentrations of nicotinamide, benzoyl peroxide, adapalene or metronidazole (Table 5); and in the pres...

Embodiment 3

[0168] Example 3: Effects of Fatty Acid Compounds on Sebocyte Cell Lines

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and / or 15-HETrE, used singly or in combination with anti-bacterial agents for the inhibition of sebum production.

Description

technical field [0001] The present disclosure generally relates to compositions comprising fatty acids or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA, and / or 15-HETrE, the fatty acids or Its derivatives are used alone or in combination with antibacterial agents to inhibit sebum production. Background technique [0002] There are more than a dozen subtypes of acne. Most types of acne result from environmental exposures, chemical exposures, physical trauma or abrasion of the skin, or sensitivity to hormone levels. One type (acne vulgaris) and related forms of acne (including, eg, necrotizing acne) have been associated with bacterial infection with Propionibacterium acnes. Currently, numerous regimens exist for treating acne, including topical application of benzoyl peroxide-containing creams. However, such creams are not always effective in reducing bacterial growth and improving the clinical manifestations of the condition. Additionally...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/202A61P17/00A61P17/10
CPCA61K9/0014A61K8/361A61K8/671A61Q19/008A61K31/202A61K31/203A61K31/192A61P17/00A61P17/10A61K2300/00
Inventor D·库格兰B·唐斯J·克利马克斯M·曼库
Owner DIGNITY SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com