Preparation device and preparation method of universal virus inactivation blood plasma

Abstract

The invention discloses a preparation device and a preparation method of universal virus inactivation blood plasma, the preparation device comprises a blood plasma mixing pool, a riboflavin solution container, a riboflavin reaction pool, a virus inactivation instrument and a centrifuge; the blood plasma mixing pool and the riboflavin solution container are connected with the riboflavin reaction pool by pipelines, and the riboflavin reaction pool is in turn connected with the virus inactivation instrument and the centrifuge. The preparation device and the preparation method can realize the continuous preparation of blood plasma, enhance the preparation efficiency of the blood plasma, can unify protein content specifications, improve the infusion efficiency, can reduce the titer of anti A and anti B two antibodies in the blood plasma, and inactivate all kinds of pathogens in the blood plasma and improve the safety of the blood plasma; and lyophilized powdery universal virus inactivation blood plasma is convenient in storage and transportation.

Description

technical field [0001] The invention relates to the technical field of plasma preparation, in particular to a general-purpose virus inactivated plasma preparation device and a preparation method thereof. Preparation of general-purpose virus-inactivated freeze-dried plasma. Background technique [0002] In the field of medical technology, virus inactivation is mainly based on physical or chemical means to dissolve and destroy the viral lipid envelope or to destroy the replication and transcription of nucleic acids, so that the virus loses its infectivity and destructive power. At present, the most common plasma virus inactivation methods include physical and chemical methods, among which chemical methods include: S / D method, methylene blue method (MB method), psoralen method and riboflavin photochemical method. Except for the S / D method, the plasma processed by the other three methods is unit plasma. [0003] In the prior art, the S / D method is only applicable to the prepar...

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Problems solved by technology

The disadvantages of this method are: the operation is cumbersome, the continuous preparation of multivariate plasma cannot be realized, and the efficiency of plasma virus inactivation treatment is low. In medical practice, when it is necessary to provide a large amount of virus inactivated plasma, Or when the patient's autologous plasma needs to be reinfused to the patient after virus inactivation, the above method cannot meet the needs of practical application

[0007] In summary, the plasma preparation devices and preparation methods in the prior art cannot realize the continuous preparation of multivariate plasma, and the preparation efficiency is low, which cannot meet the needs of practical applications in the medical field

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