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Method for preparing acid superoxide dismutase gel

A technology of dismutase gel and superoxide, which is applied in the field of polymer material preparation, can solve the problems of inability of metal ions to form covalent molecules, loss of superoxide dismutase activity, poor water holding capacity of acidic gel, etc. Mitosis, avoid infection with Trichomonas inflammation, reduce the effect of loss of activity

Inactive Publication Date: 2015-01-07
上海和森生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The acidic gel obtained by the traditional preparation method has poor water holding capacity, and is usually reduced to water after being stored for several hours after the gel is formed; the activity of superoxide dismutase is determined according to the national standard GBT5009.171-2003, and the result is super Oxide dismutase activity is almost lost
It can be seen that the problems and shortcomings of the traditional preparation method are: not resistant to acid and alkali, not resistant to enzymolysis, unable to form covalent molecules with metal ions

Method used

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  • Method for preparing acid superoxide dismutase gel
  • Method for preparing acid superoxide dismutase gel
  • Method for preparing acid superoxide dismutase gel

Examples

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preparation example Construction

[0031] The preparation method of acidic superoxide dismutase gel comprises five kinds of plant extract powders including honeysuckle extract, forsythia extract, yew extract, chamaejamas Oxide dismutase, xanthan gum are premixed and added together with hydroxyethyl cellulose to the mixed solution prepared by mixing purified water, glycerol, acetate buffer, chlorigidine acetate and menthol T80 ethanol solution, through After stirring and thickening, a gel without obvious foaming was obtained. Concrete preparation required formula is as follows:

[0032]

[0033]

[0034] Among them, the particle size range of the powder including honeysuckle extract, forsythia extract, yew extract, chamaejasma extract, geranium extract, superoxide dismutase, and xanthan gum is between 60 mesh and 120 mesh Between, the preferred particle size is 80 mesh. The concentration of glycerin is 10%-50%, preferably 20%. The viscosity of hydroxyethyl cellulose is 17000 mPa·s to 25000 mPa·s, prefer...

Embodiment 1

[0045] Example 1: the particle size is 80 mesh honeysuckle extract 1%, forsythia extract 1%, yew extract 0.1%, chamaejasma extract 0.1%, geranium extract 1%, superoxide dismutase 50ppm, Chinese 0.5% of raw rubber is pre-mixed to obtain pre-mixed powder; weigh 79.5% of purified water, and add 5% of glycerin, 10% of acetic acid buffer, T80 ethanol solution of chlorgidine acetate and menthol to prepare mixed Solution, wherein, the T80 ethanol solution of chlorogidine acetate and menthol is prepared in advance by the emulsifier T80 of 0.1% chloropigidine acetate, 0.1% menthol, and 1%; the premixed powder is mixed with hydroxyethyl cellulose 0.5 % is added to the mixed solution, stirred with a stirrer at room temperature in the purification workshop at a stirring speed of 2000rpm, and thickened to obtain a finished product without obvious foaming. The finished product has the advantages of superoxide dismutase, ensuring the pH value of the product Keep it in the range of 3.8 to 5.0...

Embodiment 2

[0046] Example 2: the particle size is 80 mesh honeysuckle extract 2%, forsythia extract 2%, yew extract 0.2%, chamaejasma extract 0.2%, geranium extract 2%, superoxide dismutase 75ppm, Chinese Raw rubber 1.7% is pre-mixed to obtain a pre-mixed powder; weigh 65.9% of purified water, and add 7.5% glycerin, 12.5% ​​acetic acid buffer, chlorogidine acetate and menthol to T80 ethanol solution to prepare a mixed Solution, wherein, the T80 ethanol solution of chlorogidine acetate and menthol is prepared in advance by the emulsifier T80 of 0.3% chloropigidine acetate, 0.6% menthol, and 2%; the premixed powder is mixed with hydroxyethyl cellulose 1.75 % was added into the mixed solution, stirred with a stirrer at a stirring speed of 2000rpm at room temperature in the purification workshop, and thickened to obtain a finished product without obvious foaming.

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Abstract

The invention relates to the technical field of high polymer material preparation, in particular to a method for preparing gel. The method for preparing acid superoxide dismutase gel includes the steps that powder such as honeysuckle extractives, forsythia extractives, taxus chinensis extractives, radix euphorbiae lantu extractives, geranium extractives, superoxide dismutase and xanthan gum is premixed; the premixed powder and hydroxyethyl cellulose are jointly added into a mixed liquid prepared by mixing purified water, glycerol, acetic acid buffer solutions, chlorhexidine acetate and T80 ethanol solutions of menthol; and the gel free of obvious bubbles is prepared through stirring and thickening. By means of the technical scheme, the gel prepared from the method for preparing the acid superoxide dismutase gel is suitable for the field of gynecological medicines, various germs in the vagina of a woman are restrained, the pH value in the vagina is maintained, the lactic acid bacillus in the vagina can be protected, and the woman is prevented from being infected by trichomonas inflammation; in addition, the gel with the sufficient superoxide dismutase activity can help the woman to repair injuries to cell mitochondria.

Description

technical field [0001] The invention relates to the technical field of polymer material preparation, in particular to a gel preparation method. Background technique [0002] Gel is a water-swellable cross-linked polymer formed by introducing a part of hydrophobic groups into a water-soluble polymer with a cross-linked structure. Water is used as the dispersion medium. It is a polymer network system that is soft in nature, can maintain a certain shape, and can absorb a large amount of water. All water-soluble or hydrophilic polymers can form gels through certain chemical cross-linking or physical cross-linking. [0003] At present, the most researched in this technical field are temperature-sensitive gel and pH-sensitive gel. The so-called temperature sensitivity means that the swelling and shrinkage of the gel in water or aqueous solution strongly depends on the temperature, and the volume of the gel has a sudden change in a certain temperature range, which is called the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K38/44A61P15/02A61P31/02A61K36/634
Inventor 陈雪华严怡
Owner 上海和森生物科技股份有限公司
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