44results about How to "Inhibits mitosis" patented technology

An exterior-applied magnesium isoglycyrrhetate in the form of ointment, cream, percutaneous paster, film, liniment, etc for treating psoriasis, chronic eczema and dermatitis, contact dermatitis, etc, and its preparing process is also disclosed.

The invention relates to the technical field of drugs, in particular to application of quinazoline compounds. The invention discloses application of the quinazoline compounds shown in the general formula I or pharmaceutically acceptable salt, prodrugs or isomers thereof in preparing mitotic inhibitors. The quinazoline compounds shown in the general formula I or pharmaceutically acceptable salt, prodrugs or isomers have the effect of inhibiting tubulin polymerization and can effectively inhibit mitosis.

The invention discloses a mutagenesis method for tetraploid petunia. The method comprises the following steps: dripping a mixed liquid medicine of Pendimethalin and colchicine to a growing point attached between two cotyledons in the process of allowing two cotyledons of diploid petunia to completely expand, and performing temperature change treatment; comparing the treated plants with contrast, selecting plants of which multiple agronomic traits such as leaf increase, leaf thickening, stem enlargement, plant height increase and column cap, anther and sepal enlargement change and of which anatomy traits such as leaf back air holes and pollen grains are obviously enlarged as variant plants; and finally, performing cytological identification, collecting small flower buds of the variant plants, observing metaphase of mitosis of pistil column cap body cells, and selecting a plant of which the chromosome number 2n is equal to 28 as a tetraploid plant. The method is short in treatment time, high in mutagenesis efficiency and simple and feasible in operation and has good application prospects, and the requirement of the identification method on instruments is low.

The invention relates to a magnesium isoglycyrrhetate emulsifiable paste preparation which contains the magnesium isoglycyrrhetate, a water-in-oil type substrate and a pH regulator; wherein, the weight of the magnesium isoglycyrrhetate accounts for 1 to 10 percent and the pH value is 6.5 to 8; an emulsifier used in the water-in-oil type substrate is span 80 and monostearin.

The invention discloses a medicine composition, and in particular relates to a traditional Chinese medicine composition for treating psoriasis, a method for preparing the traditional Chinese medicine composition, and a quality testing method thereof, and belongs to the field of traditional Chinese medicine. The effective components of the medicine composition are prepared from Rehmannia glutinosa, angelica dahurica, tortoiseshells, Paeonia lactiflora, artificial bezoar, schizonepeta spikes and other raw material medicines, and prepared into tablets, capsules, granules, pills and other preparation formulations according to clinical demands. The medicine composition has obvious function of treating or improving psoriasis.

The invention relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine for treating hyperplasia of mammary glands is characterized in that the medicine is prepared from the following raw drugs: by weight, 10g of radix paeoniae rubrathe, 15g of radix bupleuri, 10g of frankincense, 15g of semen citri reticulatae, 10g of Chinese angelica, 15g of the seed of cowherb, 5g of Poria cocos, 10g of bitter orange, 20g of red sage root, 5g of green tangerine peel, 10g of Sinapis alba, 15g of honeycomb and 20g of barbat skullcap. Through dialectical compatibility, components of the traditional Chinese medicine provided by the invention are complementary in functions, have synergistic effects, and have efficacy of soothing the liver and resolving depression, reducing phlegm and removing stasis, softening hardness and dissipating binds, invigorate blood circulation and relieving pain and the like. By the adoption of the traditional Chinese medicine, immunity of the organism can be raised, endocrine function is balanced, and hyperplastic tissues are eliminated so as to reach the purpose of treating hyperplasia of mammary glands.

The invention provides a method for culturing rhododendron fortunei polyploidy, and relates to the technical field of plant biology. The method comprises the following steps: sterilizing rhododendronfortunei seeds with oryzalin; transplanting the seeds to a seedling clod for culturing after the seeds are germinated, and detecting the ploidy variation of chromosome by a porosity method and a flowcytometer method; and transplanting the chromosome doubling plant determined by detection into greenhouse for culturing to obtain the polyploidy plant. The rhododendron fortunei polyploidy cultured byadopting the method has high inductivity reaching 30 percent, and high survival rate of variant plants reaching 85 percent or more; and the identifying method is simple and convenient, and can simultaneously prepare massive polyploidy materials, and the breeding efficiency is greatly improved.

The invention discloses a rapid identification method for the ploidy of a strawberry chromosome. The rapid identification method comprises the steps: taking a mutation-induced strawberry obtained by inducing a wild forest strawberry as a test material and a diploid wild forest strawberry as a contrast; preparing a test material stained cell nucleus suspension from the test material, and preparinga contrast stained cell nucleus suspension from a contrasted leaf; and detecting the two suspensions on a flow cytometer, analyzing the ploidy of the test material by utilizing a histogram for the relative content of DNA, and screening a ploidy-variant individual plant. The invention simultaneously provides a strawberry chromosome doubling method realized by using the rapid identification method for the ploidy of the strawberry chromosome, and the chromosome of the diploid wild forest strawberry is doubled by using oryzalin in the method. By using the method disclosed by the invention, a strawberry doubling progeny can be effectively obtained.

The invention discloses a hippophae rhamnoides extract for treating breast cancer and liver cancer as well as a preparation method and application of the hippophae rhamnoides extract. The hippophae rhamnoides extract is prepared by the following steps: 1) drying hippophae rhamnoides fruits, so that dried hippophae rhamnoides fruits are obtained; 2) crushing the dried hippophae rhamnoides fruits to 100-800 meshes so as to obtain hippophae rhamnoides powder; 3) at 4-25 DEG C, soaking the hippophae rhamnoides powder in water for 1-10h, and ultrasonically extracting for 10min-6h so as to obtain a hippophae rhamnoides extracting solution, wherein the mass-volume ratio of the hippophae rhamnoides powder to the water is 1 to (2-15); and 4) filtering, collecting the hippophae rhamnoides extracting solution and drying the extracting solution, so that the hippophae rhamnoides extract is obtained. The inhibitory rate of the extract on breast cancer cells reaches 80.73% and the inhibitory rate on liver cancer cells reaches 87.28%, and the hippophae rhamnoides extract is low in toxic and side effects.

A Chinese medicine for treating psoriasis by oral application is prepared from rosin through pulverizing, decocting in water for 3 hrs, natural cooling, filtering, drying, pulverizing and mixing with solid or liquid excipient. Its advantages are high effective rate (95.58%) and no toxic by-effect.

The invention belongs to the field of biomedicine and in particular relates to an Amolops Hainan ensis anticancer peptides Hainanenin-1 as well as a gene and an application thereof. A sequence of the anticancer peptides Hainanenin-1 is shown by amino acid in SEQ ID No. 1. The Hainanenin-1 is small in molecular weight, has a simple structure, only contains one disulfide bonds, is convenient to carry out chemical synthesis and genetic engineering preparation, is applied in preparing an anticancer drug, has broad-spectrum antineoplastic activity, has obvious killing action to MCF (Human Breast Cancer)-7 cells, has obvious growth inhibition action to other various cancer cells, and also has the beneficial effects of low hemolytic activity, nearly no toxicity to normal cells and the like. Most important of all, by adopting Hainanenin-1, due to the special cancer cell killing mechanism of Hainanenin-1, the tumor multi-drug resistance generated when traditional chemical drugs are applied is difficult to generate.

The present invention is the preparation of leukemia treating medicine with internal organs of scallop. The solution is that internal organs taken from split scallop are treated through mincing in a mincing machine, grinding in a homogenizer, mixing with ethanol, sodium benzoate and aluminium potassium sulfate while stirring, mixing with hydrochloric acid, freezing, defreezing and filtering to separate to obtain clamp peptide essence as the effective component of leukemia treating medicine. The medicine has obvious curative effect and no toxic side effect.

The invention relates to the technical field of planting, and particularly relates to a high-yield planting method of citrus. The planting method comprises the following steps: 1) selecting land and preparing soil; 2) carrying out field planting; and 3) carrying out field management: carrying out conventional field management such as pruning, pest killing, topdressing and fruit harvesting according to the growth condition of trees, wherein a weeding liquid is sprayed once every 21-31 days at a place 20-30 cm away from tree roots, and the weeding liquid is mainly prepared from the following rawmaterials: 15-17 parts of flue-cured tobacco leaves, 16-18 parts of honeysuckle stems and leaves, 13-15 parts of salvia officinalis leaves, 15-17 parts of walnut leaves, 9-11 parts of solidago altissima, 14-16 parts of catharanthus roseus, 10-15 parts of colchicum autumnale, 15-20 parts of sorghum roots, 7-9 parts of buffalo grass, 10-11 parts of polygonum orientale, 10-12 parts of erica roots, 4-6 parts of echinochloa crus-galli, 5-7 parts of climbing groundsel herb, 6-8 parts of bay leaves, 5-7 parts of asulam, 15-20 parts of water soluble azone, and the like. According to the invention, the growth of weeds is effectively inhibited, the living space of the pests is reduced, the citrus trees are fully nourished, the diseases and insect pests are reduced, and the average single-weight andthe per mu yield of the citrus are obviously increased.

The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60%, or higher, leading to a very high yield, thereby providing an effective synthesis method.

The invention provides an external application type medicine plaster for tumors. The external application type medicine plaster comprises a substrate layer and a medicine cream, wherein the medicine cream is adhered to the substrate layer; the medicine cream consists of medicine-containing extract and matrix. The external application type medicine plaster is characterized in that the medicine-containing extract is prepared from the following raw materials in parts by weight: 6 to 16 parts of rhizoma acori graminei, 6 to 16 parts of radix ranunculi ternati, 10 to 25 parts of pseudobulbus cremastrae seu pleiones, 5 to 15 parts of rhizoma sparganii, 6 to 16 parts of rhizoma curcumae, 5 to 15 parts of arisaema cum bile, 6 to 20 parts of herba taraxaci, 3 to 10 parts of radix cudramiae, 5 to 10parts of semen brassicae, 5 to 10 parts of nidus vespae, 5 to 10 parts of rhizoma pinelliae, 5 to 10 parts of spina gleditsiae, 6 to 15 parts of radix et rhizoma rhei, 6 to 20 parts of manis pentadactyla, 6 to 20 parts of chingma abutilon seed, 5 to 15 parts of cortex phellodendri, 5 to 15 parts of gecko, 5 to 10 parts of toad, 5 to 10 parts of frankincense, 5 to 10 parts of myrrh, 5 to 10 partsof flos carthami, 5 to 10 parts of radix angelicae sinensis, 5 to 10 parts of bulbus fritillariae thunbergii, and 5 to 15 parts of cottonrose hibiscus leaf.

The invention discloses a taxus chinensis modified polyester fiber, and relates to the technical field of polyester fibers. The taxus chinensis modified polyester fiber is prepared from the following components in parts by weight of 48-72 parts of taxus chinensis fiber, which is used for improving the flexibility, the rainwater-proof performance and the corrosion-resistant performance of the material and improving the circulation and metabolism functions of a human body, 5-9 parts of metal conductive fiber which is used for improving the static electricity removing performance of the material, 8-12 parts of viscose fiber which is used for improving the hygroscopicity and comfort of the material, and 6-10 parts of nano-silver which is used for improving the sterilization performance of the material. Through the combination of all the components, the material has relatively good flexibility, rainwater-proof performance and corrosion-resistant performance, the circulation and metabolism functions of a human body can be improved, the effect of preventing cancers is achieved, mitosis of cancer cells is inhibited, growth of the cancer cells is prevented, the static electricity removing performance and moisture absorption performance are relatively good, a user feels relatively comfortable when wearing the material, the sterilization performance is relatively good, and bacterium breeding is effectively inhibited.

The invention relates to the technical field of high polymer material preparation, in particular to a method for preparing gel. The method for preparing acid superoxide dismutase gel includes the steps that powder such as honeysuckle extractives, forsythia extractives, taxus chinensis extractives, radix euphorbiae lantu extractives, geranium extractives, superoxide dismutase and xanthan gum is premixed; the premixed powder and hydroxyethyl cellulose are jointly added into a mixed liquid prepared by mixing purified water, glycerol, acetic acid buffer solutions, chlorhexidine acetate and T80 ethanol solutions of menthol; and the gel free of obvious bubbles is prepared through stirring and thickening. By means of the technical scheme, the gel prepared from the method for preparing the acid superoxide dismutase gel is suitable for the field of gynecological medicines, various germs in the vagina of a woman are restrained, the pH value in the vagina is maintained, the lactic acid bacillus in the vagina can be protected, and the woman is prevented from being infected by trichomonas inflammation; in addition, the gel with the sufficient superoxide dismutase activity can help the woman to repair injuries to cell mitochondria.