Isoglycyrrhiza acid magnesium externally-applied preparation, its making method and usage

A technology of magnesium isoglycyrrhizinate and external preparations, applied in the field of external preparations of magnesium isoglycyrrhizinate, can solve problems such as incompatibility, dry and cracked skin, and achieve the effects of improving compliance and convenient use

Active Publication Date: 2007-04-04
CHIA TAI TIANQING PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the gel is easy to cause dry and cracked skin, it is not suitable for topical administration of hypertrophic lichenification such as psoriasis. We have studied other external preparations suitable for the treatment of psoriasis and dermatitis, such as ointment, cream, transdermal patch, Film agent, film coating agent and paint, have overcome above-mentioned defective, thus completed the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1: water-soluble base type ointment

[0068] Prescription (200g):

[0069] Magnesium Isoglycyrrhizinate 2g

[0070] Macrogol 4000 60g

[0071] Macrogol 400 90g

[0072] Water-soluble Azone 4g

[0073] Ethylparaben 0.2g

[0074] 10% ammonia water appropriate amount

[0075] Glycerin 10g

[0076] Distilled water up to 200g

[0077] Preparation method: 1. Dissolve magnesium isoglycyrrhizinate and an appropriate amount of 10% ammonia water in distilled water, dissolve ethylparaben in glycerin, mix well, add water-soluble azone, and stir well.

[0078] 2. Mix polyethylene glycol 4000 and polyethylene glycol 400, heat to about 70°C on a water bath, and stir well.

[0079] 3. Add (1) into (2), add water to 200g, stir until condensed, and you get it.

Embodiment 2

[0080] Embodiment 2: water-in-oil cream

[0081] Prescription (200g):

[0082] Magnesium Isoglycyrrhizinate 2g

[0083] Span 80 4g

[0084] Chlorocresol 0.4g

[0085] Beeswax 15g

[0086] Liquid paraffin 50g

[0087] White Vaseline 10g

[0088] Glyceryl monostearate 30g

[0089] 5% sodium hydroxide appropriate amount

[0090] Distilled water 88g

[0091] Preparation method: 1. Put beeswax, glyceryl monostearate, liquid paraffin, white vaseline and Span 80 into the oil phase, put it in an evaporating dish, and heat it to about 80°C on a water bath.

[0092] 2. Dissolve magnesium isoglycyrrhizinate plus an appropriate amount of 5% sodium hydroxide in distilled water, add chlorocresol, heat to about 80°C on a water bath, stir to dissolve, and form a water phase.

[0093] 3. Slowly add the water phase into the oil phase at about 80°C, and keep stirring on the water bath until it becomes a milky white semi-solid, and then stir at room temperature until it is nearly condens...

Embodiment 3

[0094] Embodiment 3: Filled closed type magnesium isoglycyrrhizinate transdermal patch

[0095]The patch described in this embodiment is composed of a backing layer, a drug storage layer, a release-controlling film, an adhesive layer and a protective layer. The materials used for each layer are as follows:

[0096] Backing layer: aluminum foil / polyethylene composite film

[0097] Protective layer: polyester film

[0098] Controlled Release Membrane: Ethylene-vinyl acetate copolymer membrane

[0099] Adhesive layer: silicone pressure sensitive adhesive

[0100] Drug storage layer (200g):

[0101] Magnesium Isoglycyrrhizinate 20g

[0102] Carbomer 4g

[0103] Appropriate amount of triethanolamine

[0104] Glycerin 20g

[0105] Azone 4g

[0106] 5% sodium hydroxide appropriate amount

[0107] Distilled water up to 200g

[0108] Preparation method:

[0109] 1. Prepare the drug storage layer:

[0110] (1) Slowly add carbomer to 50% distilled water under stirring to mak...

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PUM

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Abstract

An exterior-applied magnesium isoglycyrrhetate in the form of ointment, cream, percutaneous paster, film, liniment, etc for treating psoriasis, chronic eczema and dermatitis, contact dermatitis, etc, and its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an external preparation of magnesium isoglycyrrhizinate, including ointment, cream, transdermal patch, film, film coating and paint, as well as its preparation method and application in medicine. technical background [0002] Glycyrrhizic acid has pharmacological effects such as anti-inflammation, anti-allergy, immune regulation, anti-biological oxidation and inhibition of mutation. Clinically, diammonium glycyrrhizinate has been administered intravenously to treat psoriasis and dermatitis, such as eczema, and has a good effect. Oral preparations of glycyrrhizic acid, such as compound glycyrrhizin tablets (trade name Meineng), are also used clinically to treat skin diseases such as psoriasis and eczema, but these glycyrrhizic acid preparations have certain side effects, such as water and sodium retention, etc. patient medication compliance. At present, there is no product of topical application of glycyrrhizic acid on the mar...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K9/06A61K9/70A61P17/00A61P37/08
Inventor 程艳菊张来芳张喜全
Owner CHIA TAI TIANQING PHARMA GRP
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