Bactericidal medical ultrasonic coupling agent for ultrasonic diagnosis of wounds and preparation method thereof

Abstract

The invention provides a bactericidal medical ultrasonic coupling agent for ultrasonic diagnosis and treatment of wounds, comprising: 0.05-3% carbomer, 1-20% propylene glycol, 1-20% glycerol, 0.1-5% triethanolamine, Triclosan 0.01-0.3%, Chitooligosaccharide 0.05-10%, Menthol 0.05-5%, and the balance purified water. Add carbomer to purified water and leave it overnight to obtain solution A, weigh propylene glycol and glycerin and mix them, add triclosan, chitosan oligosaccharide and menthol, fully dissolve to obtain solution B; add solution B to solution A In, stir evenly, then add triethanolamine, fully stir, vested. The bactericidal medical ultrasonic coupling agent has a rapid broad-spectrum bactericidal effect, good acoustic performance, clear images and high resolution. Good biocompatibility, non-cytotoxic, non-sensitizing, non-mutagenic, and non-irritating to skin wounds. Does not corrode medical ultrasound probes.

Description

technical field [0001] The invention relates to a couplant, in particular to a bactericidal medical ultrasonic couplant for ultrasonic diagnosis of wounds and a preparation method thereof. Background technique [0002] In the process of ultrasonic diagnosis and treatment, it is necessary to use an ultrasonic neutral medium that is filled or coated between the radiating surface of the probe and the human epidermis and mucous membrane to transmit sound waves, that is, medical ultrasonic coupling agent. At present, the ultrasonic probe in ultrasonic examination is used repeatedly among patients at a high frequency, and is usually simply wiped after use by the patient. Although it may not necessarily cause the patient to be infected with pathogenic bacteria, there is still a great risk of cross-infection. Diseases that are easily transmitted are also good carriers. In today's environment where epidemic infectious diseases often break out on a large scale, the disinfection of med...

AI Technical Summary

Problems solved by technology

2. At present, the common high-efficiency disinfectants are often active in nature, which can not only react with pathogens, but also react with the human body, and can also react with the materials of the ultrasonic probe, which affects the service life of the probe

3. The active nature of the disinfectant often reacts with the probe and coupling agent, thus affecting the technical indicators of ultrasound

4. On the basis of solving the above problems, it is difficult to achieve rapid and powerful sterilization

If triclosan is simply added and the amount does not exceed 0.3%, it is difficult to kill pathogenic microorganisms in a short time (3 minutes)

Even individual disinfectant medical ultrasonic coupling agents compounded with bactericidal ingredients can achieve a bactericidal effect in a short period of time (3 minutes), but they have poor biocompatibility and cannot be used on wounds.

[0004] At present, self-proclaimed sterile ultrasonic coupling agents have appeared in the domestic market, but there is no real sterile ultrasonic coupling agent

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