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Application of Lycium barbarum polysaccharide in preparation of medicine for treating dry eye disease

A technology of Lycium barbarum polysaccharide and dry eye disease, applied in drug combination, sensory diseases and other directions, can solve the problems of slow onset, difficult to popularize and apply in people of different constitutions, etc., and achieve the effect of reducing lacrimal gland lesions and restoring the number of goblet cells.

Active Publication Date: 2017-11-07
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the onset of oral compound traditional Chinese medicine is slow, and it is difficult to uniformly promote and apply it to people with different constitutions

Method used

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  • Application of Lycium barbarum polysaccharide in preparation of medicine for treating dry eye disease
  • Application of Lycium barbarum polysaccharide in preparation of medicine for treating dry eye disease
  • Application of Lycium barbarum polysaccharide in preparation of medicine for treating dry eye disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Preparation of Lycium barbarum polysaccharide by decocting in water

[0023] (1) Take 10kg of wolfberry, dry it and crush it to a coarse powder, add 10 times and 8 times of water respectively, decoct twice for 1 hour each time; combine the decoctions from the two times, concentrate under reduced pressure, concentrate to 100L, and centrifuge on three legs Machine primary filtration, take supernatant filtrate 95L, and add 0.3% potassium sorbate to preserve.

[0024] (2) Use an ultrafiltration instrument, which is equipped with a roll-type ultrafiltration membrane, which allows the liquid to pass through the roll-type membrane in a laminar flow manner. Ultrafiltration pores with a certain molecular weight are distributed on the membrane. Molecular weight cut off and molecules smaller than this molecular weight are divided into two parts of liquid by ultrafiltration membrane. In this experiment, an ultrafiltration membrane with a molecular weight cut-off of 2000 was use...

Embodiment 2

[0034] 1. Preparation of wolfberry polysaccharide by microwave extraction

[0035] (1) Take 10kg of Chinese wolfberry, dry it and grind it into a coarse powder. Using pure water as solvent, the amount of water added is 10 times and 8 times the volume of the crude drug, respectively. Microwave extraction is performed twice with a 1KW-20KW microwave extractor, and 5 times are extracted respectively. For ~30 minutes, combine the two decoctions, concentrate under reduced pressure, and concentrate to 100L, the ratio of water extract to feed is 10:1, filter with a three-legged centrifuge, take 95L of supernatant filtrate, and add 0.3% sorbic acid Potassium antiseptic.

[0036] (2) Steps (2) to (8) are the same as in Example 1.

[0037] 2. Identification of polysaccharide content and molecular weight

[0038] Using the same method as in Example 1, the content of the Lycium barbarum polysaccharide obtained in this example was measured to be 97%, and the molecular weight of the Lyciu...

Embodiment 3

[0040] 1. Preparation of wolfberry polysaccharide by ultrasonic extraction

[0041](1) Take 10kg of wolfberry, dry it and crush it to a coarse powder, use pure water as the solvent, add water 10 times and 8 times the volume of the crude drug, extract twice with an ultrasonic extractor, extract for 5-30 minutes respectively, and combine The decoction was extracted twice, concentrated under reduced pressure, and concentrated to 100L. The ratio of water extract to feed was 10:1. It was first filtered by a three-legged centrifuge, and 95L of the supernatant filtrate was taken, and 0.3% potassium sorbate was added for preservation.

[0042] (2) Steps (2) to (8) are the same as in Example 1.

[0043] 2. Identification of polysaccharide content and molecular weight

[0044] Using the same method as in Example 1, the polysaccharide content of the freeze-dried powder Lycium barbarum obtained in this example was measured to be 96%, and the molecular weight was 2,000 Da to 2,000,000 Da....

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Abstract

The invention relates to a new application of lycium barbarum polysaccharide and in particular relates to an application of the lycium barbarum polysaccharide in preparation of a medicine for treating xerophthalmus, wherein molecular weight of lycium barbarum polysaccharide is more than 2000 Dalton. According to the application of the lycium barbarum polysaccharide in preparation of the medicine for treating the xerophthalmus, the medicine is an external preparation, like eye drops or gel, prepared from lycium barbarum polysaccharide and conventional dosage of medically acceptable auxiliary materials; the medicine has the advantages of being colourless, tasteless and non-irritant to mucous membranes on the surfaces of eyes.

Description

technical field [0001] The invention relates to medical preparations, in particular to medicines containing polysaccharides from plants of the genus Lycium barbarum. Background technique [0002] Lycium barbarum is the mature fruit of Lycium barbarum, a plant of the family Solanaceae, which has the effect of nourishing the liver and kidney. Lycium barbarum polysaccharide content is relatively high in Lycium barbarum, which is one of its main active ingredients. Pharmacological studies have shown that Lycium barbarum polysaccharide has biological activities such as anti-tumor, lowering blood fat, lowering blood sugar, protecting liver, preventing radiation and anti-hypoxia. At present, Lycium barbarum polysaccharide is gradually becoming a hotspot in pharmacological research and development of new drugs. [0003] Dry eye disease, also known as keratoconjunctival sicca, refers to the abnormal tear quality or quantity caused by any reason, or the decrease in tear film stabilit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P27/02
CPCA61K31/715
Inventor 王剑徐志伟刘子志
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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