Recognizing method and recognizing system of particles in blood sample and blood cell analytic instrument

A blood sample and particle technology, applied in the field of medical devices, can solve the problems of the influence of counting and classification accuracy, the decrease of the accuracy of blood cell analyzer test results, etc., and achieve the effect of improving accuracy

Active Publication Date: 2015-01-21
CHENGDU SHEN MINDRAY MEDICAL ELECTRONICS TECH RES INST +1
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  • Abstract
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  • Claims
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Problems solved by technology

image 3 It shows the distribution of white blood cells, non-cell particles and red blood cell fragments in the above double-angle amplitude scatter diagram when there are non-cell particles in the blood sample under the DIFF channel, Figure 4 It shows the distribution of white blood cells, non-cell particles and red blood cell fragments in the above double-angle amplitude scatter diagram when there are non-cell particles in the blood sample under the BASO channel, as shown in image 3 or Figure 4 As shown, the non-cell particle area will overlap with the white blood cell area. Therefore, the accuracy of counting and classification of white blood cells will be greatly affected, resulting in a decrease in the accuracy of the test results of the blood cell analyzer.

Method used

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  • Recognizing method and recognizing system of particles in blood sample and blood cell analytic instrument
  • Recognizing method and recognizing system of particles in blood sample and blood cell analytic instrument
  • Recognizing method and recognizing system of particles in blood sample and blood cell analytic instrument

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Embodiment 1

[0034] This embodiment is mainly combined with the light scattering method for classifying and counting white blood cells in a blood sample.

[0035] Before implementing the method for identifying particles in blood samples in this embodiment, it is also necessary to pre-determine and store a preset area, the preset area is corresponding to the first scattered light generated by the reference particle due to irradiation and reflects the complexity information of the reference particle. The amplitudes of the four electrical pulses and their equivalent width indicator values ​​are jointly determined, and the preset area can be reflected in the following width-angle-amplitude scatter diagram. Specifically, the reference particles can be white blood cells or simulated particles of white blood cells. Before the hematology analyzer leaves the factory, first select the DIFF channel on the hematology analyzer, and use the light scattering method to count the reference particles in the ...

Embodiment 2

[0054] The difference between this embodiment and embodiment one mainly lies in:

[0055] In this embodiment, the scatter diagram of the width, angle and amplitude obtained by detecting the blood sample in the BASO channel of the hematology analyzer is as follows: Figure 9 As shown, the figure includes a white blood cell area 902 and a non-cell particle area 903 separated by an identification boundary 901 , the white blood cell area 901 is located on the right side of the identification boundary 901 , and the non-cell particle area 903 is located on the left side of the identification boundary 901 .

[0056] It should be noted that the preset area under the DIFF channel in Embodiment 1 is different from the preset area under the BASO channel in this embodiment, and thus the identification boundaries corresponding to the preset area are also different. In addition, under the BASO channel, since there are relatively few red blood cell fragments, it is also possible to choose no...

Embodiment 3

[0058] The difference between this embodiment and any embodiment in Embodiments 1 and 2 is:

[0059] In the identification method of this embodiment: first, the sample liquid can be transported to the flow chamber in the counting system of the blood cell analyzer, so that the particles to be measured in the sample liquid pass through the optical detection area in the flow chamber one by one, when the optical system in the optical system When the light beam generated by the light source is irradiated on the particle to be measured and light scattering occurs, the two detectors convert the two sub-beams at two angles into two electric pulses, and the ratio of the area to the amplitude of the electric pulse is calculated to obtain the Measure the equivalent width indication value of the particle. Then form the corresponding relationship between the equivalent width indication value of the particle, the amplitude of the first electric pulse and the amplitude of the second electric...

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Abstract

In the application, a recognizing method and a recognizing system of particles in a blood sample and a blood cell analytic instrument are disclosed. Firstly, according to an electronic pulse corresponding to a light scattering signal generated by irradiation on to-be-tested particles in the blood sample, a leukocyte group is recognized from the blood sample; and then an equivalent width indicating value of the to-be-tested particles in the blood sample is determined with correspondence to the electronic pulse by the light scattering signal which reflects size information of the to-be-tested particles; a scatter diagram of the equivalent width indicating value to electronic pulse amplitudes of information which reflects a complex degree of the to-be-tested particles is established; and non-cell particles are recognized from the leukocyte group in a manner of comparing the to-be-tested particles with a preset area in the scatter diagram. By means of the technical scheme, the non-cell particles in the blood sample can be recognized, thereby finally eliminating influence of the non-cell particles on leukocytes and improving recognizing accuracy of the particles in the blood sample.

Description

technical field [0001] The present application relates to the technical field of medical devices, in particular to a method and system for identifying particles in a blood sample, and a blood cell analyzer. Background technique [0002] Hematology analyzer is an instrument for counting and classifying human blood cells. It is widely used in clinics and laboratories. It mainly provides white blood cell count (WBC), red blood cell count (RBC), mean red blood cell volume (MCV), platelet count (PLT), mean platelet volume (MPV), and leukocyte subset cell parameters, such as the number or percentage of lymphocytes (LYM), the number or percentage of monocytes (MON), the number or percentage of neutrophils (NEU), Test parameters such as the number or percentage of eosinophils (EOS) and basophils (BASO). [0003] Blood cell analyzers generally use electrical impedance or light scattering methods to classify and count white blood cells in blood samples. The general principle of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/14
Inventor 史兴阮雷许华明
Owner CHENGDU SHEN MINDRAY MEDICAL ELECTRONICS TECH RES INST
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