Preparation method of aluminum hydroxide adjuvant
An aluminum hydroxide and adjuvant technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, antibody medical components, etc., can solve the problems of reporting aluminum hydroxide adjuvant preparation methods, etc., and achieve the effect of high adsorption capacity
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Embodiment 1
[0028] Embodiment 1. Preparation of aluminum hydroxide adjuvant
[0029] (1) Weigh AlCl3·6H2O and dissolve it in water for injection to prepare an aluminum salt solution with an aluminum ion content of 0.25 mol / L. Weigh NaOH and dissolve it with water for injection to prepare an alkaline solution with a NaOH content of 0.265 mol / L.
[0030] (2) First add the aluminum salt solution into the reactor, then add 2 times the volume of water for injection, start stirring and mix evenly, and raise the temperature to 60°C. Use a peristaltic pump to add the alkali solution dropwise. When the dropwise addition reaches pH 4.0, add the aluminum salt solution dropwise at the same time, and keep the pH constant by adjusting the drop rate of the aluminum salt solution. The constant pH drop continued for about 40 minutes, stopped the drop of the aluminum salt solution, and continued to drop the alkali solution to pH 4.8.
[0031] (3) After the above solution is centrifuged, it is washed once...
Embodiment 2
[0035] Embodiment 2. Preparation of aluminum hydroxide adjuvant
[0036] (1) Weigh AlCl3·6H2O and dissolve it in water for injection to prepare an aluminum salt solution with an aluminum ion content of 0.25 mol / L. Weigh NaOH and dissolve it with water for injection to prepare an alkaline solution with a NaOH content of 0.265 mol / L.
[0037] (2) First add the aluminum salt solution into the reactor, then add 2 times the volume of water for injection, start stirring and mix evenly, and raise the temperature to 60°C. Use a peristaltic pump to add the alkali solution dropwise. When the dropwise addition reaches pH 3.5, add the aluminum salt solution dropwise at the same time, and keep the pH constant by adjusting the drop rate of the aluminum salt solution. The dropwise addition of constant pH continued for about 35 minutes, stopped the dropwise addition of the aluminum salt solution, and continued the dropwise addition of the alkali solution to pH 4.5.
[0038] (3) After the ab...
Embodiment 3
[0042] Embodiment 3. Preparation of aluminum hydroxide adjuvant
[0043] (1) Weigh AlCl3·6H2O and dissolve it in water for injection to prepare an aluminum salt solution with an aluminum ion content of 0.25 mol / L. Weigh NaOH and dissolve it with water for injection to prepare an alkaline solution with a NaOH content of 0.265 mol / L.
[0044](2) First add the aluminum salt solution into the reactor, then add 2 times the volume of water for injection, start stirring and mix evenly, and raise the temperature to 60°C. Use a peristaltic pump to add the alkali solution dropwise. When the dropwise addition reaches pH 3.5, add the aluminum salt solution dropwise at the same time, and keep the pH constant by adjusting the drop rate of the aluminum salt solution. The dropwise addition of constant pH lasted for about 40 minutes, stopped the dropwise addition of the aluminum salt solution, and continued the dropwise addition of the alkali solution to pH 5.2.
[0045] (3) After the above ...
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