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Method for preparing medicinal extract containing intermediate peashrub seeds

A technology of caragana seeds and extracts, which is applied in the field of preparation of medicinal extracts containing caragana seeds, can solve the problems of destroying effective components of plants, unquantifiable process parameters, low relative concentration of medicinal effective components and the like, and achieves process parameters. The effect of quantifiable, controllable process and better process

Active Publication Date: 2015-03-04
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] The purpose of the present invention is to provide a preparation method of medicinal extract containing Caragana seed, aiming to solve the traditional preparation method of boiling oil or burning charcoal to grind into powder when using Caragana seed to treat dermatitis, psoriasis, yellow water sore and impetigo sore There are problems that the process parameters cannot be quantified, the active ingredients of the plant are destroyed, and the relative concentration of the prepared medicinal active ingredients is low

Method used

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  • Method for preparing medicinal extract containing intermediate peashrub seeds
  • Method for preparing medicinal extract containing intermediate peashrub seeds

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preparation example Construction

[0044] Such as figure 1 Shown, the preparation method of the medicinal extract containing caragana seed of the embodiment of the present invention comprises the following steps:

[0045] S101: Extraction and enrichment: open the first valve, the second valve, the third valve, and the fourth valve, dry and pulverize Caragana seeds and put them into the extraction kettle, set the pressure of the extraction kettle to 25-35MPa, and the temperature to 40℃~50℃, CO 2 The flow rate is 25-40L / h, under which the Caragana seeds are extracted and enriched for 60-110 minutes;

[0046] S102: Decompression separation: set the gradient temperature and pressure reduction program in the first separation tank, that is, reduce the pressure by 0.208 MPa per minute and reduce the temperature by 0.083 °C per minute within 120 minutes, until the pressure drops to 0-10 MPa and the temperature drops to 30-30 Keep at 35°C for 15-30 minutes to obtain the medicinal extract of Caragana seed;

[0047] S...

Embodiment

[0057] Embodiment: a kind of preparation method containing caragana seed medicinal extract comprises the following steps:

[0058] Step 1, extraction and enrichment: open the first valve, the second valve, the third valve, and the fourth valve, put 250g of Caragana caragana seeds after drying and crushing into the extraction kettle, and set the pressure of the extraction kettle to 25MPa, temperature is 50℃, CO 2 The flow rate is 25L / h, under which conditions Caragana seeds are extracted and enriched for 110min;

[0059] Step 2, decompression separation: set the gradient temperature and pressure reduction program in the first separation tank, that is, reduce the pressure by 0.208 MPa per minute and reduce the temperature by 0.083 °C per minute within 120 minutes, until the pressure drops to 0 MPa and the temperature drops to 35 °C. After maintaining for 15 minutes, 16.8 g of Caragana seed medicinal extract was obtained, and the extraction and enrichment rate was 6.72%. The obt...

Embodiment 2

[0063] Embodiment 2 A kind of preparation method containing caragana seed medicinal extract, comprises the following steps:

[0064] Step 1, extraction and enrichment: open the first valve, the second valve, the third valve, and the fourth valve, put 250g of dried and crushed Caragana intermedia seeds into the extraction kettle, and set the pressure of the extraction kettle to 35MPa , at 40°C, CO 2 The flow rate is 40L / h, and the Caragana seeds are extracted and enriched for 60min under this condition;

[0065] Step 2, decompression separation: set the gradient temperature and pressure reduction program in the first separation tank, that is, reduce the pressure by 0.208 MPa per minute and reduce the temperature by 0.083 °C per minute within 120 minutes, until the pressure drops to 10 MPa and the temperature drops to 30 °C. Maintained for 30 minutes, 15 g of caragana seed medicinal extract was obtained, the extraction and enrichment rate was 6.00%, and the obtained medicinal e...

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Abstract

The invention discloses a method for preparing a medicinal extract containing intermediate peashrub seeds. The method comprises the following steps: performing extraction enrichment, performing reduced pressure separation, dispersing and mixing uniformly; separating and encapsulating, homogenizing and filtering, and collecting to obtain sterile lipidosome of the medicinal extract containing intermediate peashrub seeds. According to the method disclosed by the invention, the oily medicinal extract is extracted and enriched from the intermediate peashrub seeds in a supercritical carbon dioxide environment, and the extract is mixed and encapsulated into drug-containing lipidosome nanoparticles by virtue of a film material. Compared with a traditional medical processing method for rendering the intermediate peashrub seeds or charking co-existence ground powder, the method disclosed by the invention has the advantages that the parameters in the operating process are controllable, the temperature is low, the active ingredients of plants can be well prevented from being damaged, and solvent residue is avoided. Moreover, the drug-containing lipidosome nanoparticles prepared by the invention have the characteristics of targeted drug delivery and long-term release, and because the cell-like structure has cell biocompatibility, drug release can be performed by virtue of a cell membrane. Therefore, the therapeutic index can be improved, and the method is suitable for treatment of skin diseases such as dermatitis, psoriasis, yellow-water sore and skin itch.

Description

technical field [0001] The invention belongs to the field of dermatological drugs, in particular to a preparation method of a medicinal extract containing caragana seeds. Background technique [0002] Caragana seed refers to Caragana Korshinskii Kom., Caragana intermedia Kuang et H.C.Fu or small leaf The mature seeds of Caragana microphylla Lam are a traditional medicinal plant resource. The function of caragana seed is mainly to relieve itching, kill insects, and can treat neurodermatitis, psoriasis, yellow water sores, impetigo sores; the traditional way of administration is to boil oil and apply caragana seeds, or burn charcoal to store caragana seeds. Grind it into powder and sprinkle it on the sore surface. Contents of the invention [0003] The purpose of the present invention is to provide a preparation method of medicinal extract containing Caragana seed, aiming to solve the traditional preparation method of boiling oil or burning charcoal to grind into powder wh...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K9/127A61P17/00A61P17/06A61K131/00
CPCA61K9/0014A61K9/127A61K36/48A61K2236/37
Inventor 王小艳王洪伦索有瑞
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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