Method for preparing medicinal extract containing intermediate peashrub seeds

A technology of caragana seeds and extracts, which is applied in the field of preparation of medicinal extracts containing caragana seeds, can solve the problems of destroying effective components of plants, unquantifiable process parameters, low relative concentration of medicinal effective components and the like, and achieves process parameters. The effect of quantifiable, controllable process and better process

Active Publication Date: 2015-03-04
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
View PDF4 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a preparation method of medicinal extract containing Caragana seed, aiming to solve the traditional preparation method of boiling oil or burning charcoal to grind into powder when using Caragana seed to tre

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing medicinal extract containing intermediate peashrub seeds
  • Method for preparing medicinal extract containing intermediate peashrub seeds

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0044] Such as figure 1 As shown, the preparation method of the medicinal extract containing caragana seeds according to the embodiment of the present invention includes the following steps:

[0045] S101: Extraction and enrichment: open the first valve, the second valve, the third valve, and the fourth valve, dry and crush the caragana seeds and put them into the extraction kettle. Set the pressure of the extraction kettle to 25~35MPa and the temperature to 40℃~50℃,CO 2 The flow rate is 25-40L / h, under these conditions, the caragana seeds are extracted and enriched for 60-110min;

[0046] S102: Pressure reduction separation: Set the gradient temperature and pressure reduction program in the first separation kettle, that is, reduce the pressure by 0.208MPa per minute and 0.083°C per minute within 120 minutes, until the pressure drops to 0-10MPa and the temperature drops to 30~ Maintain at 35°C for 15-30 minutes to obtain the medicinal extract of Caragana korshinskii seed;

[0047] ...

Example Embodiment

[0056] Specific embodiments of the present invention:

Example Embodiment

[0057] Example: A preparation method of a medicinal extract containing Kagan seeds includes the following steps:

[0058] Step one, extraction and enrichment: open the first valve, the second valve, the third valve, and the fourth valve, and load the dried and crushed 250g Caragana korshinskii seeds into the extraction kettle, and set the pressure of the extraction kettle as 25MPa, temperature 50℃, CO 2 The flow rate is 25L / h. Under these conditions, the caragana seeds are extracted and enriched for 110 minutes;

[0059] Step two, pressure reduction separation: set the gradient temperature and pressure reduction program in the first separation kettle, that is, reduce the pressure by 0.208 MPa per minute and 0.083 ℃ per minute within 120 minutes, until the pressure drops to 0 MPa and the temperature drops to 35 ℃, After maintaining for 15 minutes, 16.8 g of the medicinal extract of the seeds of Caragana korshinskii was obtained, with an extraction enrichment rate of 6.72%, and the m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for preparing a medicinal extract containing intermediate peashrub seeds. The method comprises the following steps: performing extraction enrichment, performing reduced pressure separation, dispersing and mixing uniformly; separating and encapsulating, homogenizing and filtering, and collecting to obtain sterile lipidosome of the medicinal extract containing intermediate peashrub seeds. According to the method disclosed by the invention, the oily medicinal extract is extracted and enriched from the intermediate peashrub seeds in a supercritical carbon dioxide environment, and the extract is mixed and encapsulated into drug-containing lipidosome nanoparticles by virtue of a film material. Compared with a traditional medical processing method for rendering the intermediate peashrub seeds or charking co-existence ground powder, the method disclosed by the invention has the advantages that the parameters in the operating process are controllable, the temperature is low, the active ingredients of plants can be well prevented from being damaged, and solvent residue is avoided. Moreover, the drug-containing lipidosome nanoparticles prepared by the invention have the characteristics of targeted drug delivery and long-term release, and because the cell-like structure has cell biocompatibility, drug release can be performed by virtue of a cell membrane. Therefore, the therapeutic index can be improved, and the method is suitable for treatment of skin diseases such as dermatitis, psoriasis, yellow-water sore and skin itch.

Description

technical field [0001] The invention belongs to the field of dermatological drugs, in particular to a preparation method of a medicinal extract containing caragana seeds. Background technique [0002] Caragana seed refers to Caragana Korshinskii Kom., Caragana intermedia Kuang et H.C.Fu or small leaf The mature seeds of Caragana microphylla Lam are a traditional medicinal plant resource. The function of caragana seed is mainly to relieve itching, kill insects, and can treat neurodermatitis, psoriasis, yellow water sores, impetigo sores; the traditional way of administration is to boil oil and apply caragana seeds, or burn charcoal to store caragana seeds. Grind it into powder and sprinkle it on the sore surface. Contents of the invention [0003] The purpose of the present invention is to provide a preparation method of medicinal extract containing Caragana seed, aiming to solve the traditional preparation method of boiling oil or burning charcoal to grind into powder wh...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/48A61K9/127A61P17/00A61P17/06A61K131/00
CPCA61K9/0014A61K9/127A61K36/48A61K2236/37
Inventor 王小艳王洪伦索有瑞
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap