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Tetragenous egg yolk antibody oral liquid and preparation method for same

A technology of egg yolk antibody and oral liquid, which is applied in the direction of antibodies and antiviral agents, can solve the problems of inconvenient use of quadruple egg yolk antibody, improve immunity and stress ability, unaffect biological activity, and bioavailability high effect

Inactive Publication Date: 2015-03-04
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a quadruple yolk antibody oral liquid and a preparation method thereof, which solves the problem of inconvenient use of quadruple yolk antibody for injection, such as Newcastle disease, infectious bronchitis, egg drop syndrome, and avian influenza.

Method used

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  • Tetragenous egg yolk antibody oral liquid and preparation method for same
  • Tetragenous egg yolk antibody oral liquid and preparation method for same
  • Tetragenous egg yolk antibody oral liquid and preparation method for same

Examples

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Effect test

Embodiment 1

[0021] A formulation of a chicken Newcastle disease, infectious bronchitis, egg drop syndrome, avian influenza quadruple yolk antibody oral solution comprises the following raw materials: 105 L of whole egg aqueous solution containing yolk antibody, 0.2 L of caprylic acid, 0.3 L of formaldehyde, and 0.02 L of thimerosal, And penicillin and streptomycin at 1000 units / ml oral solution.

[0022] Its preparation method comprises the following steps:

[0023] 1) Use commercially available quadruple inactivated vaccines for Newcastle disease, infectious bronchitis, egg drop syndrome, and avian influenza (La Sota strain + M41 strain + EDS76 strain + HP strain) for booster immunization, and the vaccine dosage per chicken 2ml, each interval of 10 days, three immunization procedures, when the antibody titer reached 1:256, began to collect hyperimmune eggs.

[0024] 2) Sort the collected high-free eggs, sterilize with 0.2% bromogeramine, and set aside.

[0025] 3) Acidification treatme...

Embodiment 2

[0044]A formulation of a chicken Newcastle disease, infectious bronchitis, egg drop syndrome, avian influenza quadruple yolk antibody oral solution comprises the following raw materials: 95 L of whole egg aqueous solution containing yolk antibody, 0.2 L of caprylic acid, 0.2 L of formaldehyde, and 0.01 L of thimerosal, And penicillin and streptomycin at 800 units / ml oral solution.

[0045] Its preparation method comprises the following steps:

[0046] 1) Use commercially available quadruple inactivated vaccines for Newcastle disease, infectious bronchitis, egg drop syndrome, and avian influenza (La Sota strain + M41 strain + EDS76 strain + HP strain) for booster immunization, and the vaccine dosage per chicken The immunization procedure was carried out three times at intervals of 10 days. When the antibody titer reached 1:128, high-immune eggs were collected.

[0047] 2) Sort the collected high-free eggs, sterilize with 0.1% bromogeramine, and set aside.

[0048] 3) Acidific...

Embodiment 3

[0067] A formulation of a chicken Newcastle disease, infectious bronchitis, egg drop syndrome, avian influenza quadruple yolk antibody oral solution comprises the following raw materials: 100 L of whole egg aqueous solution containing yolk antibody, 0.3 L of caprylic acid, 0.3 L of formaldehyde, and 0.02 L of thimerosal, And penicillin and streptomycin at 1000 units / ml oral solution.

[0068] Its preparation method comprises the following steps:

[0069] 1) Use commercially available quadruple inactivated vaccines for Newcastle disease, infectious bronchitis, egg drop syndrome, and avian influenza (La Sota strain + M41 strain + EDS76 strain + HP strain) for booster immunization, and the vaccine dosage per chicken 2ml, each interval of 10 days, three immunization procedures, when the antibody titer reached 1:256, began to collect hyperimmune eggs.

[0070] 2) Sort the collected high-free eggs, sterilize with 0.2% bromogeramine, and set aside.

[0071] 3) Acidification treatme...

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Abstract

The invention discloses a tetragenous egg yolk antibody oral liquid and a preparation method for the same. The tetragenous egg yolk antibody oral liquid comprises the following raw materials in part by volume: 95 to 105 parts of whole egg aqueous solution containing tetragenous egg yolk antibodies to newcastledisease, infectious bronchitis, egg drop syndrome and avian influenza, 0.2 to 0.3 part of caprylic acid, 0.2 to 0.3 part of formaldehyde and 0.01 to 0.02 part of thiomersal, and each milliliter of the oral liquid further comprises 800 to 1,000 units of mycillin. The tetragenous egg yolk antibody oral liquid prepared by the method is low in production loss, high in bioactivity and free of clinical side effects, and contains multiple highly-effective immunoreactive substances; meanwhile, the tetragenous egg yolk antibody oral liquid contains various proteins in egg white, so that adverse effects on the antibodies when the tetragenous egg yolk antibody oral liquid is orally taken can be reduced.

Description

technical field [0001] The invention belongs to the technical field of biological products for poultry, and relates to a quadruple yolk antibody oral liquid and a preparation method thereof. Background technique [0002] Chicken Newcastle disease (New Castledisease), also known as Asian chicken plague or pseudo chicken plague, is a highly contagious infectious disease caused by paramyxovirus. The disease is an acute and septic infectious disease. The main features are dyspnea, loose stools, nervous disturbances, and mucosal and serosal hemorrhages. The mortality rate is high, and the poultry industry is seriously damaged. It was first discovered in Indonesia in 1926, and soon it was discovered in Newtown, England, and there are popular records in all countries in the world. [0003] Avian influenza (AI), also known as true fowl plague, is a severe infectious disease mainly prevalent in chickens caused by avian influenza virus (AIV). Highly pathogenic strains can cause sud...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/42A61P31/14A61P31/16
Inventor 徐进李建正郭俊清
Owner ZHENGZHOU HOUYI PHARMA
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