MAP2K1 marker for diagnosing closing or opening of arterial ducts

A technology of patent ductus arteriosus and reagents, which is applied in the field of clinical diagnosis of molecular biology and medicine, and can solve problems that are generally completed within 10 to 15 hours after birth.
CN104407153AInactive Publication Date: 2015-03-11SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
Publication Date
2015-03-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an MAP2K1 marker for diagnosing the closing or opening of arterial ducts. The opened and closed arterial duct tissues are identified and analyzed through an ITRAQ proteomics method, and 132 different proteins are screened out; after signal path analysis is carried out, an MAP2K1 protein is selected; the MAP2K1 protein is identified with three methods including western blot, Qrt-PCR and immunofluorescence analysis, the expression of the protein in the arterial duct tissues of a human body is proved for the first time, and the protein has a significant difference in the closed and opened arterial duct tissues, so that the protein can be a key factor for regulating and controlling the closing or opening of the arterial ducts. The MAP2K1 protein can be used for clinical diagnosis of patent ductus arteriosus, and the accuracy of diagnosis is high.
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Description

technical field

[0001] The present invention relates to the technical field of clinical diagnosis of molecular biology and medicine, in particular, relates to MAP2K1 as a marker for diagnosing closed or open ductus arteriosus. Background technique

[0002] The ductus arteriosus is a conduit between the aorta and the pulmonary artery, an important pathway for fetal circulation. After the birth of a child, the ductus arteriosus is functionally closed, and the vast majority of babies gradually close anatomically to become a ligament arteriosus about 3 months after birth. If it is not closed, it is called a patent ductus arteriosus. The closure of the ductus arteriosus is divided into two phases: 1. The first phase is the physiological closure phase. After the baby is born and cries, the first breath inhales, the alveoli will expand, and the pulmonary vascular resistance will decrease accordingly. The blood flow of the pulmonary artery will directly enter the lungs to establish...

Claims

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