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A degradable composite tubular urethral stent and preparation method thereof

A composite, tubular technology, applied in the medical field, can solve problems such as limited material intake, trauma, and complications easily caused by the site of the material, and achieve the goals of avoiding complications, promoting growth, good biocompatibility and mechanical properties Effect

Inactive Publication Date: 2017-02-22
金华市人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a degradable composite tubular urethral stent and a degradable composite tubular urethral stent for the existing long-section urethral stricture treatment method, which has the disadvantages of wounding when taking materials, limited amount of materials taken, and complications easily caused by taking materials. Preparation

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  • A degradable composite tubular urethral stent and preparation method thereof
  • A degradable composite tubular urethral stent and preparation method thereof
  • A degradable composite tubular urethral stent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A preparation method of a degradable composite tubular urethral stent, the preparation method comprising the following steps:

[0031] (1) Mix the polymer material polylactic acid PLA and polyglycolic acid PGA in a molar ratio of 50:50, and use the electrospinning technology to prepare the polylactic acid-glycolic acid copolymer PLGA nanoscale electrospun fiber membrane. The surface of the electrospun fiber membrane was modified by grafting type I collagen to obtain a modified polylactic acid-glycolic acid copolymer PLGA film;

[0032] (2) Immerse the small intestinal submucosa cells in a decellularized solution prepared by mixing polyethylene glycol octyl phenyl ether-100 (Triton X-100) with a volume concentration of 0.2% and ammonia water with a volume concentration of 0.03% , after shaking and decellularization, cryogenic freezing at -40 °C and vacuum drying were performed to obtain a small intestinal acellular matrix SIS film;

[0033] (3) According to the urethral...

Embodiment 2

[0037] A preparation method of a degradable composite tubular urethral stent, the preparation method comprising the following steps:

[0038] (1) Mix the polymer material polylactic acid PLA and polyglycolic acid PGA in a molar ratio of 75:25, and use electrospinning technology to prepare polylactic acid-glycolic acid copolymer PLGA nano-scale electrospun fiber membrane with a thickness of 0.4 mm, the porosity is 90%, the electrospinning diameter is 300-450 nm, and the pore size is 60-100 μm; the surface of the prepared electrospun fibrous membrane is grafted with type I collagen for modification to obtain the modified polylactic acid- Glycolic acid copolymer PLGA film;

[0039] (2) Immerse the small intestinal submucosa cells in a decellularized solution prepared by mixing polyethylene glycol octyl phenyl ether-100 (Triton X-100) with a volume concentration of 0.2% and ammonia water with a volume concentration of 0.03% , after shaking decellularization, cryogenically freeze at...

Embodiment 3

[0043] A preparation method of a degradable composite tubular urethral stent, the preparation method comprising the following steps:

[0044] (1) Mix the polymer material polylactic acid PLA and polyglycolic acid PGA in a molar ratio of 85:15, and use electrospinning technology to prepare polylactic acid-glycolic acid copolymer PLGA nanoscale electrospun fiber membrane. The surface of the electrospun fiber membrane was modified by grafting type I collagen to obtain a modified polylactic acid-glycolic acid copolymer PLGA film;

[0045] (2) Immerse the small intestinal submucosa cells in a decellularized solution prepared by mixing polyethylene glycol octyl phenyl ether-100 (Triton X-100) with a volume concentration of 0.2% and ammonia water with a volume concentration of 0.03% , after shaking decellularization, cryogenic freezing at -50°C and vacuum drying were performed to obtain small intestinal acellular matrix SIS film;

[0046] (3) According to the urethral diameter requi...

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Abstract

The invention provides a biodegradable composite type tubular urethral stent and a preparation method. By the biodegradable composite type tubular urethral stent and the preparation method, the shortcomings that the using quantity of the existing patch materials is limited and complications are easily caused on sampled portions are overcome. The biodegradable tissue engineering stent comprises an inner layer and an outer layer, wherein the inner layer is tubular; the outer layer is arranged on the outer surface of the inner layer; the inner layer and the outer layer are made of degradable high polymer materials and acellular stromata; the degradable high polymer materials are polylactic acid- polylactic-co-glycolic acid (PLGA) films; the acellular stromata are small intestinal submucosa (SIS) films; and the polylactic acid- polylactic-co-glycolic acid (PLGA) films and the small intestinal submucosa (SIS) films are connected to one another. By the biodegradable composite type tubular urethral stent, autologous sampling is not required during urethral canal compounding and reestablishment, and the complications which are possibly caused on the sampled portions are avoided.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a degradable composite tubular urethra stent and a preparation method. Background technique [0002] Urethral stricture caused by various factors such as traumatic or iatrogenic urethral injury, gonococcal or nonspecific urethritis and congenital urethral lesions is one of the difficult problems faced by urologists. Conventional treatment methods, including urethral dilatation, internal urethral incision, and end-to-end urethral anastomosis, are only suitable for patients with urethral strictures with a short distance. For patients with long urethral strictures, alternative surgery is mainly used. Membranes, oral mucosa, and lingual mucosa have all been used as patch materials for urethral repair surgery; however, the extraction of materials usually causes complications at the extraction site, and the amount of extraction materials is limited. SUMMARY OF THE INVENTION [0003...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82A61L31/04A61L31/10A61L31/14
Inventor 杜小文
Owner 金华市人民医院
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