The invention provides a weighing medicine box. The weighing medicine box comprises an outer box with an open top, wherein the top of the outer box is covered with a box cover, the box cover is rotatably pivoted with the outer box, the box cover is connected with the outer box through a switch device, the switch device can control the opening and closing of the box cover, a weighing sensor is arranged on a bottom plate of the outer box, a tray is arranged on the weighing sensor, the tray is provided with an object-containing box, lifting devices are separately arranged between the outer wallsof two ends of the object-containing box and the inner walls of two ends of the outer box, and the lifting devices are connected with the box cover and the outer box. According to the weighing medicine box, through the lifting devices, when the box cover is opened, the object-containing box is separated from the tray, and when the measured medium is taken from the object-containing box at the time, the force received by the object-containing box cannot be transmitted to the tray and the weighing sensor, thus the inaccurate weighing caused by repeated stress of the weighing sensor is directly avoided; and in addition, when the object-containing box is separated from the tray, the weighing sensor can be conveniently calibrated without taking out the measured medium in the object-containing box, so that the calibration operation is very convenient.