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Method for preparing electric injury paste preparation

A paste preparation, electric burn technology, applied in the direction of ointment delivery, pharmaceutical formulation, aerosol delivery, etc., can solve the problems of adding too many chemical ingredients, unable to walk outdoors, and the effect is not very ideal, and achieves a wide range of drug sources. , The effect of medicinal properties is calm and the frequency is small

Inactive Publication Date: 2015-04-01
STATE GRID CORP OF CHINA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the therapeutic effects of most drugs for treating burns are not very satisfactory. Some drugs have a long treatment cycle, or require a large amount of medication every day, which brings a lot of inconvenience to the patients. In addition, some drug patients cannot walk outdoors, which limits the The patient's activity level, or adding too many chemical ingredients to the drug, causing potential harm to the patient's body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A method for preparing ointment preparations for electric burns, the preparations are made from the following raw materials in weight proportions:

[0026] 40 parts of coptis, 40 parts of frankincense, 35 parts of half branch lotus, 35 parts of perilla leaf, 35 parts of cardamom,

[0027] 30 parts of gardenia, 30 parts of dandelion, 30 parts of Cyperus cyperi, 25 parts of tangerine peel, 25 parts of verbena,

[0028] 25 parts of Myrrh, 25 parts of Malan, 20 parts of Salvia, 20 parts of Burnet, 20 parts of Cortex Phellodendri,

[0029] Polygala 20, Mulberry 20, Shouwu 17, Dijincao 17, Safflower 17,

[0030] 15 parts of Suanzaoren, 15 parts of Puhuang, 15 parts of Cuscuta, 15 parts of Angelica dahurica, 15 parts of Magnolia officinalis,

[0031] 10 parts of peach kernel, 10 parts of peony bark, 8 parts of turmeric, and 5 parts of yam.

[0032] Its preparation method is: according to the above-mentioned parts by weight, each bulk drug is weighed

[0033] (1) Take copti...

Embodiment 2

[0039] zoology experiment

[0040] Pharmacology and Pharmacodynamics Test

[0041] One, the toxicology of topical administration of the present invention

[0042] Study on Acute Toxicity Test of Topical Drug Administration in Rat Broken Skin

[0043] Rat skin toxicity test with the maximum concentration (30 times the pharmacodynamic optimal concentration) administration once. Observed for 7 days after administration, compared with the control group, the rats in the test group neither died nor had obvious poisoning reaction. It shows that the preparation of the present invention has extremely low toxicity when administered through the damaged skin surface.

[0044] Rabbit skin irritation test

[0045] The intact skin and broken skin of New Zealand white rabbits were used to conduct multiple stimulation tests (continuous application for 7 days), and the scores were scored according to "Compilation of Guidelines for Preclinical Research of New Drugs (Western Medicine) (Pharma...

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Abstract

The invention relates to a method for preparing an electric injury paste preparation. Chinese medicinal herbs adopted in the electric injury paste preparation mainly comprise coptis chinensis, frankincense, portulaca grandiflora, folia perillae acutae, katsumadai seeds, cape jasmine, dandelion, rhizoma cyperi, dried tangerine or orange peel, vervain, myrrh and Indian kalimeris herb, effective ingredients of the Chinese medicinal herbs are extracted respectively by adopting crushing, alcohol extraction and water extraction methods, and the paste preparation is prepared by adding sesame oil. The electric injury paste preparation disclosed by the invention is remarkable in electric injury effect and wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a method for preparing ointment preparations for electric burns. Background technique [0002] Electric cauterization refers to the extensive damage to the human body, skin, subcutaneous tissue, deep muscle, blood vessels, nerves, bone joints and internal organs caused by electric current passing through the human body to produce pyroelectric effects, electrophysiological effects, electrochemical effects, electric arcs, and electric sparks. The degree varies with the temperature and the duration of action. The local changes can be divided into four degrees: the first degree: congestion due to vascular paralysis; the second degree: the formation of burn blisters filled with serum; the third degree: tissue necrosis; The fourth degree: carbonization of the organization. During burns, the amount of lactic acid in the visible blood increases, and the pH value of arteria...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/06A61P17/02
Inventor 刘学昊梁志超刘松夏晓聪孙瀚之刘靖然常俊军李娜王彬彬
Owner STATE GRID CORP OF CHINA
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