Traditional chinese medicine composite with function of treating renal injury caused by cis-platinum

Abstract

The invention relates to a traditional Chinese medicine composite with function of treating renal injury caused by cis-platinum, as well as a preparation method thereof. The composite is prepared from the following active pharmaceutical ingredients in parts by weight: 700 parts of radix rehmanniae recens, 400 parts of whitish honey, 200 parts of poria and 100 parts of radix ginseng. The preparation method comprises the following steps: accurately weighing 700 parts of radix rehmanniae recens, 400 parts of whitish honey, 200 parts of poria and 100 parts of radix ginseng; soaking radix rehmanniae recens, poria and radix ginseng with 8-fold water for 30 minutes, performing heating reflux for 4 hours, filtering and collecting a filtrate; then adding 8-fold water into filtering residues, performing heating reflux for 3 hours, filtering and collecting a filtrate; combining the two filtrates, and adding whitish honey; heating and concentrating until the heat density is 1.4kg / L (80DEG C), thus obtaining the traditional Chinese medicine. Animal experiments verify that the traditional Chinese medicine is stable in curative effect on the renal toxicity caused by cis-platinum chemotherapy, and has no influence on the cis-platinum chemotherapy effect.

Description

Technical field [0001] The present invention relates to the technical field of traditional Chinese medicine, and more specifically to the application of a traditional Chinese medicine composition composed of raw rehmannia, white honey, poria and ginseng in the treatment of kidney injury caused by cisplatin and a preparation method thereof. Background technique [0002] Cisplatin is a highly effective anti-tumor drug, widely used in the treatment of breast cancer, head and neck cancer, lung cancer, ovarian cancer and other solid tumors. It has the characteristics of broad anti-cancer spectrum, strong effect, synergistic effect with multiple anti-tumor drugs, and no cross-resistance. It is one of the most commonly used drugs in current combined chemotherapy, but cisplatin has obvious nephrotoxicity. In clinical use, 20%-30% of patients are forced to stop using it due to renal toxicity. After intravenous injection, cisplatin is distributed in the liver, kidney, large and small inte...

AI Technical Summary

Problems solved by technology

However, reports have shown that this method may cause water-electrolyte disorders in patients, further increasing the burden on the kidneys

Aiming at the mechanism of cisplatin-induced cis-injury, some people choose some apoptosis inhibitors, antioxidants, etc., but the pathway of cisplatin-induced kidney injury is often the pathway for cisplatin to treat tumors, so blocking these pathways in anticipation of reducing the side effects of drugs actually also reduced the anticancer effect of cisplatin

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