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Pericarpium citri reticulatae and eupatorium composition for reducing chemi-therapy vomiting

A composition and technology of dried tangerine peel, applied in the directions of drug combination, digestive system, plant raw materials, etc., can solve the problems of unbearable pain for patients, disordered acid-base balance, high price, etc., achieve good anti-emesis effect, high industrial practicability, and obtain handy effect

Inactive Publication Date: 2015-05-06
QINGDAO UNIV
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AI Technical Summary

Problems solved by technology

Frequent vomiting can lead to a large loss of digestive juice, water, electrolyte, and acid-base balance disorders, making the patient miserable, seriously affecting the patient's quality of life, not only affecting the curative effect, but even making the patient unbearable and interrupting the treatment
[0003] At present, the commonly used antiemetic drugs in clinic mainly include histamine (H 2 ), acetylcholine (M) and dopamine (DA) receptor antagonists and cannabinoids, etc., but these drugs have poor curative effect on vomiting after chemotherapy, and have strong toxic and side effects, so their application is greatly limited
Newer antiemetics, such as NK 1 Antagonists and 5-HT 3 Receptor antagonist drugs, although effective in antiemetic and antiemetic after chemotherapy, are expensive, have a narrow range of use, and have large toxic and side effects, so they often need to be used in combination in clinical practice

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment approach

[0024] The first step: preparation of various extracts

[0025] (1) Preparation of the concentrated extract of Chenpi Peilan decocted in water

[0026] Take tangerine peel and Peilan according to the compatibility ratio of 1:1, soak in distilled water, heat and decoct, filter, save the filtrate, add distilled water to the dregs, soak, decoct, and filter in the same way, mix the two filtrates, heat and concentrate to a small volume , filtered with an ultrafiltration membrane, and dried under reduced pressure.

[0027] (2) Preparation of tangerine peel polysaccharide

[0028] Chenpi was crushed and sieved, refluxed with 80% ethanol for 30 minutes, the surface fat was removed, suction filtered, and air-dried. The degreased sample was extracted twice with a Soxhlet extractor for 30 minutes each time, and the two extracts were filtered under reduced pressure. Remove the filter residue, combine the two filtrates and concentrate under reduced pressure to a small volume to obtain th...

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Abstract

The invention relates to a pericarpium citri reticulatae and eupatorium composition for reducing chemi-therapy vomiting. The composition is prepared from a pericarpium citri reticulatae and eupatorium decocted and concentrated extract, pericarpium citri reticulatae polysaccharide, eupatorium volatile oil and eupatorium alkaloid at the ratio of 4 to 6 to 7 to 8. The composition has a good curative effect on vomiting caused by cancer chemotherapy.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition, more specifically relate to a kind of natural medicine composition that is made up of orange peel Peilan decoction concentrated extract, dried orange peel polysaccharide, Perrin volatile oil and Perrin alkaloid, and this natural medicine composition is used for preparing Use in a drug to reduce vomiting caused by cancer chemotherapy. Background technique [0002] Cancer has become a major killer facing human beings, and its mortality rate is second only to cardiovascular diseases, and it is increasing year by year. There are 1.8 million malignant tumor patients in my country every year, and 2 / 3 of them receive chemotherapy. Although there is a certain curative effect, most patients will experience side effects to varying degrees after chemotherapy. The most common side effects are nausea, vomiting and other gastrointestinal symptoms. reaction. Frequent vomiting can lead to a large ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P1/08A61K31/715
Inventor 石振艳刘萍
Owner QINGDAO UNIV
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