A method for granulating cross-linked sodium hyaluronate gel

A technology of cross-linking hyaluronic acid and sodium hyaluronate, applied in the direction of raw material extrusion granulation, etc., can solve the problems affecting the yield, difficult to control the gel particle size and uniformity, etc., achieve uniform texture, improve The effect of granulation efficiency

Active Publication Date: 2016-08-24
HANGZHOU SINGCLEAN MEDICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the cryogenic mill reduces the heat generation between the rotor and the material, it is not easy to control the size and uniformity of the gel particle size, and the prepared gel particle size range is wide, which affects the yield.

Method used

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  • A method for granulating cross-linked sodium hyaluronate gel
  • A method for granulating cross-linked sodium hyaluronate gel
  • A method for granulating cross-linked sodium hyaluronate gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: As a filler for treating soft tissue injuries.

[0050] Select 1# stator and rotor combination, follow the attached figure 1 , 2 Perform the assembly of the granulating device. Start the cooling water circulation system, set the speed to 3000rpm, and run the split head. After the actual speed reaches the set parameters, pass in 0.04MPa compressed air.

Embodiment 2

[0051] Example 2: As a filler for treating stress urinary incontinence.

[0052] Select 1# stator and rotor combination, follow the attached figure 1 , 2 Perform the assembly of the granulating device. Start the cooling water circulation system, set the speed to 10000rpm, and run the split head. After the actual speed reaches the set parameters, pass in 0.04MPa compressed air.

Embodiment 3

[0053] Example 3: As a temporary particle embolization agent, to avoid accidental embolism caused by small particle embolization agent.

[0054] Select 1# stator and rotor combination, follow the attached figure 1 , 2 Perform the assembly of the granulating device. Start the cooling water circulation system, set the speed to 3000 rpm, and run the split head. After the actual speed reaches the set parameters, pass in 0.10 MPa compressed air.

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Abstract

The invention provides a method for granulating cross-linked sodium hyaluronate gel. The method comprises the following steps: the sodium hyaluronate gel in a feeding container is input into a dividing head by using a pneumatic force under a sealed condition, and sequentially passes through an inlet flange and a central material conveying hole of a stator to be input into a gap between the stator and a rotor; and the stator and the rotor rotate oppositely and then the sodium hyaluronate gel flows out of the dividing head through an outlet flange to finish granulation. A cooling water circulation system is used for cooling the whole dividing head. Meanwhile, the rotor is fixed on a main shaft of a speed reducing motor so that the relative rotation speeds of the stator and the rotor can be adjusted. The gap between the stator and the rotor can be realized by replacing different combinations.

Description

Technical field [0001] The invention relates to a method for granulating cross-linked sodium hyaluronate gel. Background technique [0002] Due to its high mechanical strength and long degradation time, the cross-linked modified sodium hyaluronate gel becomes an effective clinical tissue filling material. But the cross-linked sodium hyaluronate has quite high strength. During the production process, it needs to be prepared into particles within a certain particle size range before it can be injected through an injection needle. At the same time, for the cross-linked sodium hyaluronate gel as a dermal filler, the particle size range of the particles needs to be controlled, and the largest particle size should be controllable. The largest particles may make it difficult to push the gel particles out of the syringe during the injection process, which will directly affect the injection effect. Therefore, how to granulate the cross-linked sodium hyaluronate gel and effectively contr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J2/20
CPCB01J2/20
Inventor 蒋婷
Owner HANGZHOU SINGCLEAN MEDICAL PROD
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