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Multi-microcapillary reactor used for continuously preparing carrier particles

A technology of carrier particles and microtubes, applied in chemical/physical/physical-chemical reactors, chemical instruments and methods, chemical/physical/physical-chemical processes, etc. problem, to achieve the effect of easy manufacturing, simple design and structure, and wide application prospects

Active Publication Date: 2015-05-06
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing microchannel reactors are not easy to scale up, and large-scale preparation is still difficult

Method used

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  • Multi-microcapillary reactor used for continuously preparing carrier particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 The present invention takes 316 stainless steel as the material of described multi-microcapillary reactor, gets long 40mm, Ф The 19×1.5 mm 90-degree stainless steel clamp quick-loading elbow is used as the inlet section of the multi-microtube reactor to facilitate connection; the circular table diversion section is stamped and formed by a mold and polished, with a wall thickness of 1.5 mm and a total height of 142 mm, side edge length 131 mm; its top end is connected to the inlet section through a clamp joint; the bottom end is welded with a flange with an outer diameter of 180 mm, a thickness of 9 mm, and a central through hole that matches the fluid distributor; the fluid distribution The segment consists of a height of 20 mm and an inner diameter of Ф The stainless steel cylinder of 109×2 mm is composed of a stainless steel distributor disc with a thickness of 9 mm that matches its inner diameter. There are 97 uniformly distributed small holes on the di...

Embodiment 3

[0027] Example 3 With the same other dimensions as in Example 1 but small holes on the disc of the distributor Ф 4 mm, microtube size Ф The 2.8×0.3 mm stainless steel multi-microtube reactor is used as the application object, with 2% (w / w) sodium alginate as the aqueous solution as the reaction solution, 10% CaCl 2 The solution was a cross-linking agent, and the immobilized carrier was continuously prepared at a flow rate of 120 mL / min. The particle size of the porous carrier particles obtained through pore formation was 3.4±0.1 mm.

Embodiment 4

[0028] Example 4 With the same other dimensions as in Example 1 but small holes on the disc of the distributor Ф 4 mm, microtube size Ф The 2.8×0.3 mm stainless steel multi-microcapillary reactor was used as the application object, and the sodium alginate (2%, w / w) suspension containing 0.5% (w / w) brewer’s yeast cells was used as the reaction liquid, and 10% CaCl 2 The solution was a cross-linking agent, and the immobilized carrier was continuously prepared at a flow rate of 120 mL / min. The particle size of the microbe-immobilized porous carrier particles obtained by pore formation was 3.5±0.1 mm.

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Abstract

The invention discloses a multi-microcapillary reactor used for continuously preparing carrier particles. The multi-microcapillary reactor mainly comprises an inlet pipe section, a circular platform flow guide section, a fluid distributor section, a multi-microcapillary section and the like. Fluid reaction liquid enters a reactor body from the inlet pipe section and flows out from the multi-microcapillary section after being distributed by the circular platform flow guide section and the fluid distributor section to form liquid drops capable of reacting and having relatively uniform diameters; and the fluid reaction liquid forms porous carrier particles after being subjected to corresponding cross-linking reaction or polymerization reaction and pore formation. The reactor has a simple design and structure and is easy to machine; a production process is easy to realize, and the carrier particles with uniform granularity can be prepared; and the multi-microcapillary reactor has a wide application prospect in the fields of bioengineering, dosage forms, material engineering, chemical engineering, biomedical engineering and the like.

Description

technical field [0001] The invention belongs to the technical field of chemical machinery equipment, and in particular relates to a multi-microtube reactor for continuously preparing carrier particles. Background technique [0002] Porous carrier particles have important applications in many fields such as bioengineering, material engineering, chemical engineering, pharmaceuticals, and biomedical engineering. Common carrier particles include microbial immobilization carrier particles, biological separation media, drug carriers, tissue engineering scaffold particles, etc. These carrier particles not only need to have a certain distribution of pores, but also need a uniform particle size. [0003] However, it is difficult to prepare carrier particles with uniform particle size. In recent years, based on the method of microfluidic forming, the controllable preparation of carrier particles can be achieved through microchannels, and carrier particles with uniform particle size c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00
CPCB01J19/0053B01J19/0093B01J2219/00013B01J2219/00033B01J2219/00792B01J2219/00855B01J2219/00869
Inventor 张玮陈冰冰郑三龙杨玉军徐林红
Owner ZHEJIANG UNIV OF TECH