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Novel preparation method of antelope cold preparation

An antelope cold and preparation technology, which is applied in the direction of pill delivery, antiviral agents, and medical preparations of non-active ingredients, etc., can solve the problems of time-consuming preparation and mixing methods, low bioavailability of crushed fine powder, etc., and improve drug production. Effects of bioavailability, improvement of stability and solubility, and shortening of working hours

Inactive Publication Date: 2015-05-13
SHANDONG ZHONGTAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The present invention provides a new preparation process of antelope cold preparation, aiming to overcome the disadvantages of low bioavailability of pulverized fine powder and time-consuming preparation and mixing method in the traditional preparation process of antelope cold preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0026] Put Nepeta Nepeta and Forsythia in a multifunctional extraction tank, add water to the extent that the medicinal materials can be submerged, extract the volatile oil, and store the extract in another container. The dregs are mixed with four kinds of medicinal materials such as light bamboo leaves, burdock seeds, licorice, and light tempeh, and placed in an extraction tank, and extracted twice, each time for 2 hours; the first time adding water is 8 times the total weight of the medicinal materials, and the second time Add 6 times of water at a time; combine the decoction, let it stand for 16 hours, filter, and concentrate the filtrate (vacuum degree: -0.06~-0.08Mpa, temperature 60~80°C) until the relative density is 1.10 (65°C).

[0027] The antelope horn, Platycodon grandiflora and honeysuckle in the prescription are pre-crushed, mixed and pulverized in an ultrafine pulverizer for 20 minutes, and passed through a 300-mesh sieve to make fine particles with an average par...

Embodiment example 2

[0031] Put Nepeta Nepeta and Forsythia in a multifunctional extraction tank, add water to the extent that the medicinal materials can be submerged, extract the volatile oil, and store the extract in another container. The dregs are mixed with four kinds of medicinal materials such as light bamboo leaves, burdock seeds, licorice, and light tempeh, and placed in an extraction tank, and extracted twice, each time for 2 hours; the first time adding water is 8 times the total weight of the medicinal materials, and the second time Add 6 times of water at a time; combine the decoction, let it stand for 16 hours, filter, and concentrate the filtrate (vacuum degree: -0.06~-0.08Mpa, temperature 60~80°C) until the relative density is 1.10 (65°C).

[0032] The antelope horn, Platycodon grandiflora and honeysuckle in the prescription are pre-crushed, mixed and pulverized in an ultrafine pulverizer for 20 minutes, and passed through a 300-mesh sieve to make fine particles with an average par...

Embodiment example 3

[0036] Put Nepeta Nepeta and Forsythia in a multifunctional extraction tank, add water to the extent that the medicinal materials can be submerged, extract the volatile oil, and store the extract in another container. The dregs are mixed with four kinds of medicinal materials such as light bamboo leaves, burdock seeds, licorice, and light tempeh, and placed in an extraction tank, and extracted twice, each time for 2 hours; Add 6 times of water each time; combine the decoction, let it stand for 24 hours, filter, and concentrate the filtrate (vacuum degree: -0.06~-0.08Mpa, temperature 60~80°C) to a relative density of 1.10 (65°C) to produce a paste.

[0037] The antelope horn, Platycodon grandiflora and honeysuckle in the prescription are pre-crushed, mixed and pulverized in an ultrafine pulverizer for 30 minutes, and passed through a 300-mesh sieve to make fine particles with an average particle size between 12um and 15um and a maximum of 47um.

[0038]Dissolve the extracted vo...

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Abstract

The invention discloses a novel preparation method of an antelope cold preparation. Characteristics and curing functions of the antelope cold preparation and characteristics and curing functions of antelope cold pills disclosed by Chinese pharmacopoeia (2010) standards are the same. The novel preparation method comprises following steps: 1) schizonepeta and fructus forsythia are subjected to volatile oil extraction, an obtained water distillate is collected in another container, obtained herb residue is mixed with lophatherum gracile, burdock, liquorice, and fermented soybean, an obtained mixture is subjected to 2h of decoction extraction for two times, filtering is carried out, an obtained mixed material is mixed with the water distillate, an obtained product is concentrated so as to obtain an extract; 2) antelope horn, platycodon grandiflorum, and lonicera japonica are subjected to pre-crushing, mixing, and superfine grinding, and obtained powder is sieved using a sieve of 300 meshes so as to obtain microparticles with an average particle size of 12 to 15<mu>m, wherein the largest particle size is less than 47<mu>m; 3) the volatile oil obtained in step 1) and dementholized peppermint oil are dissolved in 95% ethanol respectively so as to obtain a volatile oil ethanol solution, beta-cyclodextrin is dissolved in hot water of 60 to 80 DEG C so as to obtain a beta-cyclodextrin saturated solution, the volatile oil ethanol solution is added into the beta-cyclodextrin saturated solution slowly, heat-preservation stirring is carried out for 30 to 50min, an obtained solution is refrigerated and is allowed to stand for 24h, and a beta-cyclodextrin inclusion compound is obtained via filtering and drying, wherein the amount of ethanol is 3 to 7 times of the amount of the volatile oil and dementholized peppermint oil; and 4) the microparticles, and the beta-cyclodextrin inclusion compound are uniformly mixed with appropriate auxiliary materials, the extract obtained via step 1) is added, and particle preparations, or tablet preparations, or capsule preparations are prepared.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine preparation technology. Background technique [0002] Lingyang Ganmao Tablets is a patented traditional Chinese medicine recorded in the Chinese Pharmacopoeia (2010 edition). It has the effect of clearing away heat and relieving exterior symptoms. treat. In the Chinese Pharmacopoeia (2010 edition), its prescription and preparation process are as follows: [0003] [Prescription] Antelope horn 3.4g Burdock seed 109g Light tempeh 68g [0004] Honeysuckle 164g Nepeta 82g Forsythia 164g [0005] Bamboo leaves 82g Bellflower 109g Licorice 68g [0006] Peppermint Oil 0.68ml [0007] 【Preparation process】Antelope horn file is ground into fine powder; Campanulaceae and 1 / 2 honeysuckle are crushed into fine powder, sieved, blended with antelope horn powder, and mixed evenly; Nepeta and forsythia extract volatile oil, and distilled aqueous solution is separated. Preserve; decoct the ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/20A61K9/48A61K47/48A61P11/00A61P31/16A61K35/32
Inventor 何小波彭向前李向阳刘红粉
Owner SHANDONG ZHONGTAI PHARMA
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