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Application of CCR4 antagonist in inhibiting cancer growth and metastasis

1. The technology of CCR4 and antagonists, which is applied in the field of biomedicine, can solve problems such as the growth and metastasis of liver cancer that have not yet been reported by CCR4 antagonists, and achieve good clinical application prospects.

Active Publication Date: 2015-05-20
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there have been no reports of CCR4 antagonists being used to treat the growth and metastasis of liver cancer

Method used

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  • Application of CCR4 antagonist in inhibiting cancer growth and metastasis
  • Application of CCR4 antagonist in inhibiting cancer growth and metastasis
  • Application of CCR4 antagonist in inhibiting cancer growth and metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Compound

[0020] 1. The small molecule compound c-021 was purchased from Tocris Company (product number: 3581, purity>99%), and the molecular formula of the compound is C 27 h 41 N 5 o 2 2HCl, the structure is as follows:

[0021]

[0022] 2. The small molecular compound ST45177901 was purchased from Timtec Company (product number: MFCD04147999, purity>99%), and the molecular formula of the compound is C 26 h 16 ClN 3 o 4 S 3 , with the following structure:

[0023]

Embodiment 2

[0024] Example 2: Animal Experiments of CCR4 Antagonists Used to Treat the Growth and Metastasis of Liver Cancer

[0025] The mouse liver cancer orthotopic transplantation model can effectively simulate the process of natural growth, invasion and metastasis of liver cancer, and is a commonly used animal experimental model for the study of liver cancer (Gao YS, Chen XP, Li KY, Wu ZD. Nude mice model of human hepatocellular carcinoma via orthotopic Implantation on of histologically intact tissue. World J Gastroenterol. 2004.10: 3107-3111). Therefore, it was used to verify the effect of compound c-021 and ST45177901 on the growth and metastasis of liver cancer.

[0026] 1. Animals

[0027] C57 / 6BL mice, male, weighing 20-24 g, were reared in groups of 6 mice / cage, divided into 4 groups. They were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. and kept in an SPF grade animal room.

[0028] 2. Cells

[0029] Using the luciferase reporter system fr...

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Abstract

The invention relates to an application of a CCR4 antagonist in inhibiting cancer growth and metastasis, belongs to the technical field of biological medicines, in particular relates to the CCR4 antagonist, and specially relates to an application of C-021 and ST45177901 in inhibiting cancer growth and metastasis especially liver cancer growth and metastasis. A compound provided by the invention has good clinical application prospects in inhibiting cancer growth and metastasis especially liver cancer growth and metastasis.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of CCR4 antagonists in inhibiting cancer growth and metastasis. Background technique [0002] Liver cancer is one of the most common clinical malignant tumors, with the characteristics of high malignancy, rapid progression, and poor prognosis, which seriously threatens human health and life safety. China is the country with the highest incidence and the highest number of deaths from liver cancer in the world, accounting for about 55% of the world's liver cancer patients. In recent years, the incidence of liver cancer in the world has been on the rise, and the number of new cancer cases in China ranks first in the world, and the number of new cases and deaths of liver cancer ranks first in the world. Because the liver has a rich blood supply, vascular metastasis is the most important way of liver cancer metastasis. It has been reported that more than 90% of c...

Claims

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Application Information

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IPC IPC(8): A61K31/517A61K31/433A61P35/00A61P35/04
Inventor 杨鹏远
Owner INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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