A kind of compound sj-11 extracted from Shanxi and its preparation method and application

A technology of SJ-11 and compound, applied in the field of medicine, can solve problems such as no public reports, achieve huge economic and social benefits, and inhibit tumor cells.

Active Publication Date: 2016-05-25
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

According to the literature reports, the main chemical components of the mountain lily include volatile oils, alkaloids, and flavonoids. The compound is extracted from chrysanthemum so as to find a new application, but no public report has been seen so far.

Method used

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  • A kind of compound sj-11 extracted from Shanxi and its preparation method and application
  • A kind of compound sj-11 extracted from Shanxi and its preparation method and application
  • A kind of compound sj-11 extracted from Shanxi and its preparation method and application

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Embodiment Construction

[0025] The specific embodiments of the present invention will be described in detail below with reference to the drawings and specific conditions.

[0026] In the specific implementation of the present invention, the preparation method of the compound of the present invention includes the following steps:

[0027] (1) Preparation of ethanol extract extract: take dried yamaka powder and grind it into a 60-80 mesh sieve powder, add 10-12 times the weight of yamaka powder with 95% ethanol at 90-95℃ Reflux and extract for 2-3 hours in a water bath and filter to obtain the first filtrate; the drug residue after the first filtrate is added to 95% ethanol with a mass concentration of 8-10 times the weight of yamakura powder at 90-95℃ Reflux and extract for 2-3 hours in a water bath and filter to obtain the second filtrate; the medicine residue after the second filtrate is added to ethanol with a mass concentration of 95%, which is 6-8 times the weight of yamakuri powder, at 90-95℃ Reflux...

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Abstract

The invention relates to a compound SJ-11 extracted from lindera reflexa hemsl as well as a preparation method and an application of the compound SJ-11, effectively solving the problem that a novel compound is extracted from the lindera reflexa hemsl. The method comprises the steps of extracting the lindera reflexa hemsl by utilizing ethanol to obtain ethanol extracted lindera reflexa hemsl extract liquid, and concentrating the lindera reflexa hemsl extract liquid to obtain ethanol extract cream; extracting the ethanol extract cream by utilizing ethyl acetate, concentrating the lindera reflexa hemsl ethyl acetate part total extract liquid to obtain lindera reflexa hermsl ethyl acetate part thick paste; drying the lindera reflexa hermsl ethyl acetate part thick paste to obtain lindera reflexa hermsl ethyl acetate part dry cream; adding methanol and silica gel of the same quantity into the lindera reflexa hermsl ethyl acetate part dry cream to obtain a mixture, feeding the mixture on a silica gel column, eluting the mixture by utilizing a mixed solution consisting of petroleum ether and chloroform, evaporating and drying the elution solution to obtain an elution dry cream; repeatedly feeding the elution dry cream on the silica gel column, and carrying out separation and purification, column chromatography and recrystallization to obtain the compound SJ-11. The compound SJ-11 can be effectively used for preparing a medicine for treating the tumor, and a novel use of the medicinal value of the lindera reflexa hemsl is developed.

Description

Technical field [0001] The present invention relates to medicine, in particular to a compound SJ-11 extracted from yamaka and its preparation method and application. Background technique [0002] The dry roots of Linderareflexa Hemsl., a plant of the genus Linderareflexa Hemsl. of the Lauraceae family (Lauraceae), are included in the "Henan Standard of Chinese Medicinal Materials" (1993 edition). And other effects. According to reports in the literature, the main chemical components of yamui include volatile oils, alkaloids, flavonoids, etc. With the improvement of the medicinal value of yamui, there are more and more studies on the active ingredients of yamui. There are no public reports on the extraction of compounds from 橿 in order to find new uses. Summary of the invention [0003] In view of the above situation, in order to overcome the shortcomings of the prior art, the purpose of the present invention is to provide a compound SJ-11 extracted from yamaka and its preparatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C39/23C07C37/70A61P35/00
CPCC07C37/004C07C39/23C07C2601/16
Inventor 陈随清魏雅磊王利丽孙孝亚
Owner HENAN UNIV OF CHINESE MEDICINE
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