Mussel mucoprotein gel for wound repair, and preparation method and application thereof

A technology for mussel mucin and wound repair, which is applied in the fields of peptide/protein components, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., and can solve the problem that sprays cannot meet the requirements of various clinical departments , to achieve the effect of promoting effective healing, good coupling effect, and increasing compliance

Inactive Publication Date: 2015-05-27
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Problems solved by technology

[0004] At present, mussel mucin wound repair materials are all in the form of sprays, but in clinical applications, sprays cannot meet the requirements of various clinical departments, such as gynecology, so it needs to be developed on the basis of maintaining the healing and antipruritic activities of mussel mucin More dosage forms

Method used

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  • Mussel mucoprotein gel for wound repair, and preparation method and application thereof
  • Mussel mucoprotein gel for wound repair, and preparation method and application thereof
  • Mussel mucoprotein gel for wound repair, and preparation method and application thereof

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preparation example Construction

[0035] A preparation method of mussel mucin gel for wound repair, comprising the following steps:

[0036] a. Swelling and sterilization of matrix: Mix the viscosifier, stabilizer, preservative, and wetting agent that meet the pharmacopoeia standards according to the proportion, stir evenly, add medicinal dissolved water to fully swell, and adjust the pH value to 3.8~ with a pH regulator 5.8, make it form a transparent gel, sterilize it for 15-30 minutes under the pressure of 0.1-0.15 MPa and 120-126°C, and cool it for later use;

[0037] b. Protein sterilization and filtration: add human serum albumin to the mussel mucin raw material drug solution, dilute the two with medicinal dissolved water, mix well, and filter to sterilize with a 0.22 μm filter membrane under sterile conditions;

[0038] c. Gel preparation: Under sterile conditions, fully mix the two substances in steps a and b, subpackage, and store at 4°C.

[0039] The above-mentioned mussel mucin gel for wound repair...

Embodiment 1

[0042] Take carbomer 9400.1g, sodium lauryl sulfate 1g, methylparaben 1g, glycerin 10g, add medicinal dissolved water to 80g, mix well, adjust the pH to 3.8 with acetic acid-ethyl ester, and then 1. Under the condition of 120°C, autoclave for 15 minutes, cool to room temperature, and make the matrix part. Add 1 g of human serum albumin and 0.15 g of mussel mucin into the matrix, add medicinal dissolved water to 100 g, stir slowly and evenly, and prepare the mussel mucin gel.

Embodiment 2

[0044] Take carbomer 9101g, Tween 0.1g, ethylparaben 2g, propylene glycol 8g, add medicinal dissolved water to 80g, mix well, adjust the pH to 3.8-5.8 with acetic acid, and then under the conditions of 0.15MPa and 120℃ , autoclave for 20 minutes, cool to room temperature, and make the matrix part. Add 5 g of human serum albumin and 0.16 g of mussel mucin into the matrix, add medicinal dissolved water to 100 g, and stir slowly to make mussel mucin gel.

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Abstract

The invention provides a mussel mucoprotein gel for wound repair, and a preparation method and an application thereof. The mussel mucoprotein gel for wound repair comprises the following raw materials in percentage by weight: 0.15-0.2% of mussel mucoprotein, 0.1-5% of protein protector, 0.1-5% of tackifier, 0.1-5% of stabilizer, 0.1-5% of preservative, 1-10% of wetting agent, 0.1-5% of pH (potential of hydrogen), and 64.8-98.35% of medical dissolving water. With Carbomer as a substrate, the mussel mucoprotein gel has good extending property, is easy to coat and adhere on a skin, has no irritation to skin and mucosa and can absorb tissue penetrating fluid, so secretions can be exhausted conveniently; the gel is not greasy, the medicines are released fast, and the coupling effect with skin tissues is excellent.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a mussel mucin gel for wound repair and its preparation method and application. Background technique [0002] The loss or dysfunction of tissues and organs is one of the major hazards to human health and the leading cause of human disease and death. According to statistics, tens of millions of patients need to be treated every year in my country due to burns, mechanical injuries or chronic skin ulcers. Medical repair materials are an important guarantee for human health. Their application not only saves the lives of tens of millions of critically ill patients, but also plays an important role in improving the quality of life and health of patients and reducing medical costs. The rapid development of the medical repair material industry in the international market is growing into a pillar industry of the world economy. However, the medical repair materials in my coun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K47/32A61K9/06A61P17/02
Inventor 姚正军徐丹周金堂刘沛江
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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