Traditional Chinese medicine composition for treating children with rheumatoid arthritis and preparation method thereof

A rheumatoid and arthritis technology, which is applied in the field of traditional Chinese medicine composition for treating children with rheumatoid arthritis and its preparation, can solve the problems of high toxicity and side effects of drugs, and achieve strong targeting, convenient administration, and strong joints Effect

Inactive Publication Date: 2015-06-10
青岛申达高新技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is that there is a need for a traditional Chinese medicine preparation for the treatment of rheumatoid arthritis that relieves pain, improves swelling, prevents joint deformation, and relieves the pain of sick children. In the past, chemical medicine and Chinese patent...

Method used

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  • Traditional Chinese medicine composition for treating children with rheumatoid arthritis and preparation method thereof
  • Traditional Chinese medicine composition for treating children with rheumatoid arthritis and preparation method thereof
  • Traditional Chinese medicine composition for treating children with rheumatoid arthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0075] The preparation method of capsule of the present invention:

[0076] Sangjisheng 1500g, Rehmannia glutinosa 1500g, Fangfeng 1500g, Angelica 1500g, Drynaria 1500g, Gentiana 1500g, Earthworm 1500g, Psoralen 1500g, Achyranthes bidentata 1500g, Geranium 1500g, Dipsacus 1500g, Danpi 1500g, Shenjincao 1500g, Clematis 1500g, Paeoniae Alba 1500g, Wood Beetle 1500g, Atractylodes 1500g, Curcuma 1500g, Corydalis 1500g, Eucommia 1500g, Polygonum cuspidatum 1500g, Duhuo 1500g, first cut all raw materials into coarse particles, and then put them into In ethanol, soak for more than 2 hours, add 8 times the amount of ethanol and 6 times the amount of the total mass of the raw drug, and heat and extract twice, the extraction time is 2 hours and 1 hour; combine the 2 extracts, and the extracts are passed through the tube Centrifuge to obtain a centrifuge, which is absorbed by D 101 macroporous resin, washed with water to remove impurities, and then eluted with 70% ethanol, collected elua...

experiment example 2

[0095] Experimental example 2: Cumulative toxicity test:

[0096] Traditional Chinese medicine preparation of the present invention is taken orally honey refined pills to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine of the present invention The preparation has no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. After 1 week and 3 weeks after stopping the drug, there was no significant change in the organs of the rats. Explanation The oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

experiment example 3

[0097] Experimental Example 3: Results of Acute Percutaneous Toxicity Test

[0098] The medicinal compound preparation for external use of the present invention has the effects of expelling wind and dampness, promoting blood circulation and dredging collaterals, and is used for treating rheumatism, rheumatoid arthritis and other diseases. Accordingly, the acute percutaneous toxicity test was first carried out to observe whether the drug's acute percutaneous toxicity to rats is actually non-toxic.

[0099] Test substance: the preparation ointment for external use of the present invention. Weigh 50g of the test substance and add distilled water to make a 50% paste for later use.

[0100] Experimental animals: 20 SD rats were provided by the Experimental Animal Center of Shandong Provincial Academy of Traditional Chinese Medicine, male and female, weighing 180-220g, first-class animals (Yidongzi No. 08-25), and the source of feed was the same as above. Animal room environment: ...

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Abstract

The invention provides a traditional Chinese medicine composition for treating children with rheumatoid arthritis and a preparation method thereof. Internal medicine comprises the following raw material medicines: loranthus parasiticus, prepared rehmannia root, divaricate saposhnikovia root, angelica, rhzizoma drynariae, gentiana macrophylla, earthworms, fructus psoraleae, radix achyranthis bidentatae, erodium stephanianum willd, teasel root, cortex moutan, lycopodium clavatum, radix clematidis, radix paeoniae alba, woodlouse, rhizoma atractylodis, radix curcumae, rhizoma corydalis, eucommia, polygonum cuspidatum and radix angelicae pubescentis; and external medicine comprises the following raw material medicines: tripterygium glycosides, cassia twig, frankincense, myrrh, ligusticum wallichii, nux vomica, honeysuckle stem, scorpio, resina draconis, woodlouse, teasel root, earthworms, safflower, beefwood-like clubmoss herb, polygonum cuspidatum, tuberculate speranskia herb and homalomena occulta. The traditional Chinese medicine composition provided by the invention is orally taken and is externally used and has the functions of clearing away heat and eliminating dampness, preventing joint deformity, relieving pain and relieving swelling. The technology has the advantages of convenience in administration, direct access to lesions, strong targeting, easiness for manufacturing the medicine, low cost and the like. The internal use and external use are combined to ensure the functions of replenishing the vital essence and removing heat, dredging the collaterals by resolving damp, eliminating pain, preventing joint deformity and generating no influence of the development of children; and the traditional Chinese medicine composition can promote normal bone growth and reinforce the joints.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine composition for treating infantile rheumatoid arthritis and a preparation method thereof. Background technique [0002] In recent years, due to the market economy, social changes, and the accelerated and tense pace of life, pediatric rheumatoid arthritis has become common and frequent. It is still a difficult problem in the medical field, and the incidence rate has a clear upward trend. Those who are seriously ill can't work, study, take care of themselves because of limited activities, and even become disabled, which seriously affects people's health, and even causes great pain and misfortune to a person's life. Both patients and physicians desire highly effective, reliable therapies for these bone diseases. But so far, no matter whether it is ancient or new, whether it is domestic or foreign,...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K36/889A61K36/896A61P19/02A61P29/00A61K9/48A61K9/06
Inventor 不公告发明人
Owner 青岛申达高新技术开发有限公司
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