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Preparation method and application of safflower seed meal for hypoglycemic effective fraction

A technology of safflower seed meal and effective parts, which is applied in the field of preparation of safflower seed meal's hypoglycemic effective parts, and can solve the problem of not finding the anti-diabetic activity of safflower seed meal

Active Publication Date: 2018-03-09
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, after searching, there are many studies on the preparation of the effective part of safflower seed meal for hypoglycemic effect, but the research group applied for "a kind of hypoglycemic use of safflower seed meal extract" and has In addition to the hypoglycemic activity of 5-hydroxytryptamine contained in it, there is no report that safflower seed meal has diabetes prevention activity, but the method in the patent also involves the use of chloroform, which has certain limitations in practical application

Method used

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  • Preparation method and application of safflower seed meal for hypoglycemic effective fraction

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 400g of safflower seeds for cleaning, crushing, degreasing according to the conventional method, put it in a round bottom flask, add 5 times the volume concentration of 50% ethanol aqueous solution, temperature 40 ℃, heat and reflux extraction 3 times, each time 4h , filter, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, and obtain 29.8g of safflower seed meal extract;

[0017] Add the safflower seed meal extract to the aqueous solution to dissolve and disperse, add the pre-treated macroporous resin HPD100 column for adsorption, wash with water until the reducing sugar (MOLISH) reaction is negative, and then use 5 times the volume concentration of 10%, 70%, 95% Gradient elution with ethanol aqueous solution, 10% and 95% effluents were collected and concentrated to obtain 4.11 g of effective fraction of safflower seed meal with hypoglycemic activity.

Embodiment 2

[0019] Take 400g of safflower seeds, wash them, crush them, degrease them according to conventional methods, place them in a round-bottomed flask, add 10 times the volume concentration of 55% ethanol aqueous solution at a temperature of 50°C, heat and reflux for extraction 3 times, each time for 3h , filter, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, and obtain 32.4g of safflower seed meal extract;

[0020] Add the safflower seed meal extract to the aqueous solution to dissolve and disperse, add the pre-treated macroporous resin HPD300 column for adsorption, wash with water until the reducing sugar (MOLISH) reaction is negative, and then use 5 times the volume concentration of 10%, 70%, 95% Gradient elution with ethanol aqueous solution, 10% and 95% effluents were collected and concentrated to obtain 4.92 g of effective fraction of safflower seed meal with hypoglycemic activity.

Embodiment 3

[0022] Take 400g of safflower seeds for cleaning, crushing, degreasing according to the conventional method, put in a round bottom flask, add 10 times the volume concentration of 60% ethanol aqueous solution, temperature 60 ℃, heating and reflux extraction 3 times, each time 2h , filtered, combined extracts, concentrated under reduced pressure until no alcohol smell, to obtain 31.6g of safflower seed meal extract;

[0023] Add the safflower seed meal extract to the aqueous solution to dissolve and disperse, add the pre-treated macroporous resin HPD500 column for adsorption, wash with water until the reducing sugar (MOLISH) reaction is negative, and then use 5 times the volume concentration of 10%, 70%, 95% Gradient elution with ethanol aqueous solution, 10% and 95% effluents were collected and concentrated to obtain 4.62 g of effective fraction of safflower seed meal with hypoglycemic activity.

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Abstract

The present invention relates to the preparation method and application of safflower seed dregs for hypoglycemic effective fractions. The effective fractions for hypoglycemic effect are obtained from safflower dregs by reflux extraction with organic solvents and macroporous resin separation and purification, and its medical application is clarified. The activity screening test proves that the effective fraction obtained by the method of the present invention has protein tyrosine phosphatase 1B (PTP-1B) and α-glucosidase inhibitory effects, and can be used as a raw material or auxiliary agent for preventing and treating diabetes or Health products.

Description

technical field [0001] The invention relates to the preparation and application of the effective part of safflower seed meal for lowering blood sugar. Background technique [0002] Safflower seeds, called "Baipingzi" in traditional Chinese medicine, are the seeds of Safflower (Carthamustinctorius L.). Safflower meal is a by-product of extracting safflower oil from safflower seeds. Safflower is an ancient 1 to 2-year herbaceous plant, which has a history of 4,000 years in ancient Egypt. There are now 20-25 species of Safflower recognized. Since Zhang Qian introduced safflower from the Western Regions to my country, it has a history of more than 2100 years of cultivation and medicinal use. At present, safflower is mainly distributed in more than 20 provinces (districts) such as Henan, Zhejiang, Sichuan, Yunnan, and Xinjiang. Most of them are flowers and oil of safflower for medicinal purposes, and safflower seed meal is rarely used, which has not caused enough Pay attentio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/286A23L33/105A61P3/10A23L33/00
Inventor 信学雷萨拉麦提·艾迪热斯艾级买力汗·艾比布拉谢连珍阿吉艾克拜尔·艾萨
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI