Application of honey in dynamic long-term near-infrared targeted imaging reagents of inflammatory sites
A targeted imaging and near-infrared technology, applied in echo/ultrasound imaging agents, nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo tests, etc., can solve the real-time, dynamic, long-term Time course and other issues, to achieve high-sensitivity rapid tracking and monitoring, simultaneous diagnosis and accurate targeted positioning and treatment, and broad medical application prospects
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Embodiment 1
[0026] The application of honey in the dynamic long-term near-infrared targeted imaging reagent of the inflammatory site, the steps are:
[0027] 1) Construct a wound in the lower abdomen of Drosophila, induce an inflammation model, and set it as an experimental model group; set up a normal control group and a blank group at the same time.
[0028] 2) Inject 0.05ml of aseptic honey, propolis or royal jelly with a concentration of 30g / L into the experimental model group and the normal control group through a microinjector; the blank group is not treated.
[0029]3) During the period of 1 to 6 hours, through non-invasive real-time dynamic high-sensitivity rapid fluorescent tracing and detection, observe the transport of imaging reagents in Drosophila and enrich them in inflammatory lesions; the specific operations are:
[0030] Using a macro-zoom fluorescence microscope to image, select different time points such as 1 hour, 2 hours, and 6 hours, and put the fruit flies in CO 2 ...
Embodiment 2
[0034] 1) Create wounds on the neck or head of C57 mice, or induce inflammatory models such as cerebral apoplexy, and divide them into experimental model group and control model group; set up normal control group and blank control group at the same time.
[0035] 2) 0.3ml sterile concentration of 30g / L of honey, propolis or royal jelly or a mixture of any two reagent solutions, injected into the normal control group and experimental model group mice; control model group and blank Groups are not processed.
[0036] 3) During the period of 1 to 72 hours, through non-invasive real-time dynamic high-sensitivity rapid fluorescent tracing and monitoring, observe the circulation of the targeted reagent in the mouse body and enrich the inflammatory lesion; the specific steps are:
[0037] Use the in vivo fluorescence imager to image, select different time points such as 1 hour, 4 hours, 8 hours, 12 hours, 24 hours, 48 hours, etc., and then anesthetize the mice with 5% isoflurane gas...
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