Method for preparing soybean isoflavone aglucone by using acetic acid to catalyze hydrolysis of soybean isoflavone glycoside

A technology of acetic acid catalyzing glycoside type and soybean isoflavones, which is applied in the direction of organic chemistry, etc., to achieve the effect of simple operation, green and environmental protection of the catalytic process, and low acidity

Inactive Publication Date: 2015-06-24
JILIN INST OF CHEM TECH
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  • Abstract
  • Description
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Problems solved by technology

[0003] In view of the technical defects of hydrochloric acid catalysis, alkali catalysis and enzyme catalysis in the existing process of converting soybean isoflavones to aglycones, edi

Method used

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Embodiment Construction

[0011] Take 30 mg of 90.64% soybean isoflavone glucoside and place it in a 50 mL round bottom flask, add 1.5 mol L -1 Add 5 mL of acetic acid aqueous solution, then add 5 mL of absolute ethanol, and ultrasonic water bath for 1 hour, ultrasonic frequency 45 KHz, water bath temperature 75 ° C. The reaction liquid was transferred to an autoclave, the reaction temperature was 160° C., and the reaction time was 4 hours. After the reaction was completed, the reaction liquid was cooled to room temperature. Take a certain amount of the reaction solution and neutralize it with saturated sodium carbonate aqueous solution to pH = 7, extract with ethyl acetate, take the ester layer, spot on a silica gel plate, put in a developing solvent (ethyl acetate: chloroform: methanol = 5:5 : 2) Expand in middle, observe the degree of hydrolysis under ultraviolet light; take another certain amount of reaction solution and dilute it to 100ppm with methanol, use HPLC to qualitatively and quantitative...

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Abstract

The invention discloses a method for preparing soybean isoflavone aglucone by using acetic acid to catalyze hydrolysis of soybean isoflavone glycoside. The method comprises a step of hydrolyzing soybean isoflavone glycoside in a raw material into soybean isoflavone aglucone at a certain temperature and a certain pressure by taking 90.64% glucoside type soybean isoflavone glycoside as the raw material and food additive grade acetic acid as a catalyst, wherein the hydrolysis rate of soybean isoflavone aglucone reaches 100%. The process disclosed by the invention is simple in operation, and more importantly, edible acetic acid is used as the catalyst to ensure that the hydrolysis process is completely green and environment-friendly, and a hydrolysis product can be directly used for soybean health products and functional foods without separation, so that the problems of equipment corrosion, wastewater pollution and poor edible product safety in an inorganic acid catalytic process are solved. The method disclosed by the invention is a practical technology suitable for industrial production of soybean isoflavone aglucone.

Description

technical field [0001] The invention relates to a method for preparing soybean isoflavone aglycone by catalyzing soybean isoflavone glucoside hydrolysis with acetic acid. Background technique [0002] Soy isoflavones are secondary metabolites produced during the growth of soybeans and other leguminous plants. Studies have found that intake of sufficient amounts of soy isoflavones can effectively reduce the risk of osteoporosis, climacteric syndrome, and hypercholesterolemia. , and the risk of cardiovascular disease and cancer. There are three main types of isoflavones naturally present in soybeans, namely genistein, daidzein and glycitein, each of which exists in four main forms: malonyl Glucoside type, acetyl glucoside type, β-glucoside type and aglycone type (aglycone), among which the combined glycoside accounts for 80% to 95% of the total isoflavone content. Studies have found that soybean isoflavones in the form of glycosides cannot be directly absorbed by the small i...

Claims

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Application Information

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IPC IPC(8): C07D311/36
CPCC07D311/36
Inventor 于丽颖成乐琴罗亚楠张俭
Owner JILIN INST OF CHEM TECH
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