(E) -2-phenyl-3- (3,5-di oxygen-4-isopropine) Puritic acid method
A technology of dimethoxy, cumene, applied in the field of pharmacy, can solve problems such as inability to achieve mass production, inability to obtain purity, and difficulty in separation
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[0042] Example 1 A purification method of (E)-2-phenyl-3 (3,5-dimethoxy-4-isopropylbenzene) acrylic acid
[0043] A method for purifying (E)-2-phenyl-3 (3,5-dimethoxy-4-isopropylbenzene) acrylic acid, which comprises two steps:
[0044] The first step is to selectively esterify (E)-2-phenyl-3(3,5-dimethoxy-4-isopropylbenzene)acrylic acid with a purity of 80% to obtain a purity of 90% % of (E)-2-phenyl-3(3,5-dimethoxy-4-isopropylphenyl)acrylic acid a; react according to the following equation:
[0045]
[0046] Follow the steps below in order:
[0047] 10 g of crude (E)-2-phenyl-3 (3,5-dimethoxy-4-isopropylbenzene) acrylic acid with a purity of 80% (its HPLC diagram is shown in Figure 5 Shown) was added to 60mL of isopropanol and stirred to dissolve, then 0.1g of concentrated sulfuric acid was added dropwise, and the temperature was raised to 60°C. After reacting for 5 hours, cooled to room temperature, the alcohol solvent isopropanol was removed, and ether and saturated ...
Embodiment 2-6
[0056] The purification method of embodiment 2-6 (E)-2-phenyl-3 (3,5-dimethoxy-4-isopropylbenzene) acrylic acid
[0057] Examples 2-6 are respectively a purification method of (E)-2-phenyl-3(3,5-dimethoxy-4-isopropylbenzene)acrylic acid, similar to the purification method of Example 1, The only difference is that the technical parameters involved are different, and the specific differences are shown in the following table:
[0058]
[0059] Note: Substance A in the above table represents (E)-2-phenyl-3(3,5-dimethoxy-4-isopropylphenyl)acrylic acid; substance Aa represents (E)-2-phenyl- 3(3,5-Dimethoxy-4-isopropylphenyl)acrylic acid a; Substance A product represents the final (E)-2-phenyl-3(3,5-dimethoxy-4 - cumene) acrylic products.
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