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Albumin-containing pharmaceutical composition and application thereof

A technology of albumin and composition, which is applied in the field of albumin and pharmaceutical composition containing albumin, which can solve problems such as reaction, inability to develop at will, death, etc., to reduce urinary protein, reduce renal function damage, and reduce The effect of glomerulosclerostinuria

Inactive Publication Date: 2015-07-08
河南省医药科学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Human serum albumin is a medicine extracted from human plasma, which is an indispensable class of special medicine for prevention and / or treatment in modern medicine. Its only raw material is human blood, so it is restricted by social, economic and political factors and cannot develop at will
However, if animal serum albumin is directly injected into the human body without processing, it will definitely react and even cause death.

Method used

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  • Albumin-containing pharmaceutical composition and application thereof
  • Albumin-containing pharmaceutical composition and application thereof
  • Albumin-containing pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: the preparation of denatured bovine blood albumin

[0044]Weigh 10g of bovine serum albumin, add deionized water to dissolve it and make it to 100mL, add 0.45mL of 38% w / v formaldehyde, shake well, let it stand for 30 minutes, add 1mmol / L sodium hydroxide to adjust the pH to 8.9 . Place at 113°C for 1 hour, then at 4°C for 6 weeks, and finally at 100°C for 1.5 hours. Then, 0.9 g of sodium chloride was added, and then 1 mmol / L hydrochloric acid was added to adjust the pH to 7.6. After sterilization, place it in a water bath at 100°C for 30 minutes to obtain denatured bovine serum albumin (the yield is about 100%).

Embodiment 2

[0045] Embodiment 2: the preparation of denatured porcine serum albumin

[0046] Weigh 10g of porcine serum albumin, add deionized water to dissolve it and make it to 100mL, add 0.45mL of 38% w / v formaldehyde, shake well, let stand for 30 minutes, add 1mmol / L sodium hydroxide to adjust the pH to 8.9 . Place at 113°C for 1 hour, then at 4°C for 6 weeks, and finally at 100°C for 1.5 hours. Then, 0.9 g of sodium chloride was added, and then 1 mmol / L hydrochloric acid was added to adjust the pH to 7.6. After sterilization, place it in a water bath at 100°C for 30 minutes to obtain denatured porcine serum albumin (the yield is about 100%).

Embodiment 3

[0047] Example 3: Effect of the concentration of human serum albumin on proteinuria in NS rats

[0048] The 20% w / v human serum albumin for injection used in this test was from Jet Behring Pharmaceutical Co., Ltd., Germany, and other concentrations of human serum albumin were prepared from the above-mentioned 20% w / v human serum albumin for injection.

[0049] The preparation method of 2.5% w / v human serum albumin: take 3.75 mL of 20% w / v human serum albumin for injection, add 26.25 mL of sterile pyrogen-free normal saline, and mix well.

[0050] Preparation method of 5% w / v human serum albumin: Take 7.5 mL of 20% w / v human serum albumin for injection, add 22.5 mL of sterile pyrogen-free normal saline, and mix well.

[0051] The preparation method of 10% w / v human serum albumin: take 15 mL of 20% w / v human serum albumin for injection, add 15 mL of sterile pyrogen-free normal saline, and mix well.

[0052] The preparation method of 15% w / v human serum albumin: take 22.5 mL of ...

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Abstract

The invention relates to an albumin, an albumin-containing pharmaceutical composition and application thereof, in particular to a pharmaceutical composition containing an albumin of 10% w / v or an albumin of lower concentration and application of the pharmaceutical composition to preparation of medicines for preventing and / or treating nephrosis. The invention also relates to a method for preparing a degeneration animal blood albumin.

Description

technical field [0001] The present invention relates to albumin, a pharmaceutical composition containing albumin and its use in the preparation of medicines, in particular to the use of albumin and the pharmaceutical composition containing albumin in the preparation of medicines for preventing and / or treating nephropathy. Background technique [0002] Minimal glomerular lesions are a group of primary glomerular diseases characterized by normal glomeruli under light microscope, diffuse fusion of foot processes of glomerular epithelial cells and obliteration of foot process holes under electron microscope . [0003] Nephrotic syndrome (NS) is a group of clinical symptoms characterized by hyperproteinuria, hyperlipidemia, edema, hypoalbuminemia (three high and one low) and other metabolic disorders. If the symptoms of NS are not effectively controlled, it can lead to serious complications, such as renal failure, uremia, etc., which seriously threaten the physical and mental he...

Claims

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Application Information

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IPC IPC(8): A61K38/38A61P13/12C07K14/765C07K1/113A61K31/573
Inventor 何美霞贺石林邢国兰阚全程张勇朱建立李晓天孔燕芳温战迎张彭俊华海婴李志刚赵瑛瑛杜斌张莉蓉张卫茹
Owner 河南省医药科学研究院
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