C17-heteroaryl derivatives of oleanolic acid and methods of use thereof

A technology of heteroaryldiyl and alkyl groups, which can be used in medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, and can solve problems such as differences

Active Publication Date: 2015-07-08
REATA PHARMA INC
View PDF9 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although betulinic acid derivatives have shown comparable anti-inflammatory properties, their pharmacology also appears to be significantly different compared to OA-derived compounds (Liby et al., 2007b)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
  • C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
  • C17-heteroaryl derivatives of oleanolic acid and methods of use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] Disclosed herein are novel compounds and compositions having antioxidant and / or anti-inflammatory properties, methods of their manufacture, and methods of their use, including methods for treating and / or preventing disease.

[0026] I. Definition

[0027] When used in the context of chemical groups: "hydrogen" means -H; "hydroxyl" means -OH; "oxo" means =O; "carbonyl" means -C( =O)-; "Carboxyl" means -C(=O)OH (also written as -COOH or -CO 2 H); "halo" means independently -F, -Cl, -Br or -I; "amino" means -NH 2 ; "Hydroxyamino" means -NHOH; "nitro" means -NO 2 ; imino means =NH; "cyano" means -CN; "isocyanate" means -N=C=O; "azido" means -N 3 ; in a monovalent context, "phosphate group" means -OP(O)(OH) 2 or its deprotonated form; in a divalent context, "phosphate" means -OP(O)(OH)O- or its deprotonated form; "mercapto" means -SH; and "thio / Thio" means =S; "sulfonyl" means -S(O) 2 -; and "sulfinyl" means -S(O)-.

[0028] In the context of a chemical formula, the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula (I): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.

Description

[0001] This application claims the benefit of U.S. Provisional Patent Application No. 61 / 699,199, filed September 10, 2012, which is hereby incorporated by reference in its entirety. [0002] Pursuant to 37 C.F.R.1.821(c), the Sequence Listing is hereby filed in an ASCII text file named "REATP0076US_SequenceListing_ST25.txt (REATP0076US_Sequence Listing_ST25.txt)" dated September 9, 2013 created and has a size of about 1KB. The entire contents of the aforementioned documents are hereby incorporated by reference. Background technique [0003] I.Technical field [0004] The present invention relates generally to the fields of biology and medicine. More specifically, the present invention relates to compounds, compositions and methods for the treatment and prevention of diseases, such as those associated with oxidative stress and inflammation. [0005] II. Description of related technologies [0006] The anti-inflammatory and anti-proliferative activities of the naturally occ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K31/56A61P29/00
CPCC07D271/10C07J63/008C07D271/06A61P29/00A61P39/06
Inventor 江昕克里斯多福·F·班德麦琳·维斯尼克
Owner REATA PHARMA INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap