Novel application of prunus padus extract in preparing alcoholic liver injury protection medicines and health products
An alcohol-induced liver injury and extract technology, which is applied in the field of medicine with new activity of traditional Chinese medicine extracts, can solve the problems of chemical liver injury without a good treatment strategy, easy to evolve into hepatitis, and even liver cirrhosis.
Active Publication Date: 2015-07-15
JILIN AGRICULTURAL UNIV
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Problems solved by technology
[0002] Chemical liver injury is a common liver disease, which is mainly caused by a series of damage caused by oxidative stress. If it is not paid enough attention, it is easy to develop into hepatitis, liver fibrosis, liver necrosis, and even liver cirrhosis and liver cancer. No good treatment strategy for chemical liver injury
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experiment example
[0014] Experimental example. Protective effect of pickle extract on alcohol-induced acute liver injury in mice
[0015] 1 Materials and methods
[0016] 1.1 Apparatus
[0017] BP211D analytical balance (Shanghai Shuxin Instrument Co., Ltd.); HC-2517 high-speed centrifuge (Anhui Zhongke Zhongjia Scientific Instrument Co., Ltd.); high-speed tissue homogenizer (Weifang Sanshui Inspection Equipment Co., Ltd.); continuous spectrum scanning enzyme SpectraMaxPlus384 (American Molecular Biological Instrument Company); YD-6D automatic biological tissue embedding machine, paraffin slicer (Zhejiang Jinhua Yidi Medical Equipment Factory).
[0018] Materials and reagents
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The invention belongs to the technical field of medicines, and mainly discloses a novel application of a prunus padus extract in preparing alcoholic liver injury protection medicines and health products. Experiment researches show that the prunus padus extract has a significant protection effect on mice of alcohol-induced liver injury, and the prunus padus extract can be used for effectively reducing ALT, AST and TG levels in mice serum, increasing GSH level in liver tissue and lowering the MDA level of a lipid peroxidative product. Therefore, the extract can be used for preparing medicines, health products, food additives, compound preparations and the like for protecting liver. The medicines or health products can be in any existing dosage forms such as tablet, capsule, powder injection, injection, pill, soft capsule, granule, patch and the like.
Description
technical field [0001] The invention relates to a new application of thick plum extract in the preparation of liver damage protection medicine and health care product, and belongs to the medical technical field of novel activity of traditional Chinese medicine extract. Background technique [0002] Chemical liver injury is a common liver disease, which is mainly caused by a series of damage caused by oxidative stress. If it is not paid enough attention, it is easy to develop into hepatitis, liver fibrosis, liver necrosis, and even liver cirrhosis and liver cancer. There is no good treatment strategy for chemical liver injury. However, a variety of active ingredients found in traditional Chinese medicine have obvious preventive and therapeutic effects on liver damage. Therefore, it is of theoretical and practical significance to seek and discover preparations for the prevention and treatment of chemical liver injury from natural medicines. [0003] There are many kinds of p...
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IPC IPC(8): A61K36/736A61P1/16A23L1/29A23L33/00
Inventor 李伟张晶林红梅王梓毛欣欣李慧萍王英平
Owner JILIN AGRICULTURAL UNIV