Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction

A technology of uterine contraction and cockles, applied in the direction of drug combination, medical raw materials derived from molluscs, freeze-dried transportation, etc., can solve the problems that uterine contraction has not been reported.

Inactive Publication Date: 2015-08-12
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Compendium of Materia Medica" records: "wax, sweet and warm, and non-toxic in nature, sweet and warm can benefit qi and nourish the middle, then the five internal organs will be safe, stomach qi will be strong, confidantes, waist and spine will b

Method used

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  • Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1, preparation has the cockles extract that has effect of promoting postpartum uterine contraction:

[0011] (1) Appropriate amount of cockle meat, homogenized;

[0012] (2) Add 1.5 times the volume of distilled water, and ultrasonically assist extraction at 30°C for 25 minutes;

[0013] (3) Stir and extract in a water bath at 30°C for 2 hours, centrifuge at 4000r / min for 5 minutes, take the supernatant, repeat the above operation for the residue, combine the filtrates, concentrate under reduced pressure to 1 / 3 volume, and freeze-dry to obtain the cockles extract.

Embodiment 2

[0014] Example 2: The effect of cockles extract on uterine contraction of isolated mice

[0015] Preparation of isolated mouse uteri: 2 days before the experiment, non-pregnant female mice were intraperitoneally injected with estradiol valerate every day to improve the sensitivity of the uterus to drugs; the mice were killed quickly by cervical dislocation, and the uteri were taken out by laparotomy to make about 1.0 cm strips of uterine smooth muscle. Put the uterus ligated with silk thread into a Maxwellian bath filled with 20ml, fix one end of the silk thread ligated to the specimen fixing hook in the bath, and connect the other end to the tension transducer, and give the uterus a load of 1g. After the uterine contraction is stable, the normal contraction curve is recorded. For each group, add 1 drop of motherwort aqueous solution (as a control) and various concentrations of cockle extracts, and after the uterine contraction is stable, use Biolap420E + The biological sig...

Embodiment 3

[0017] Embodiment 3: the preparation of cockle seed extract tablet

[0018] prescription:

[0019] Cockle Seed Extract 100mg

[0020] Lactose 100mg

[0021] Starch 295mg

[0022] Magnesium Stearate 5mg

[0023] Total 500mg

[0024] Weigh out the main ingredients respectively, mix the cockle seed extract powder with 80 mesh sieve, lactose, and starch, granulate with wet method, dry, mix with magnesium stearate after integration, press into tablets, and press into 500mg per tablet tablet.

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Abstract

The present invention discloses a blood clam extract and the application thereof in medicaments for promoting the postpartum uterine contraction. The blood clam extract contains water-soluble materials extracted from the meat of the blood clam and has the uterine contraction function. The blood clam extract can be used for the treatment on uterus subinvolution after postpartum hemorrhage, drug abortion, and induced abortion.

Description

technical field [0001] The invention relates to a new application of marine active substance cockles extract in the preparation of medicine for uterine contraction. Background technique [0002] Clams, commonly known as clams and clams, belong to the phylum Molluscs, Class Phyllobranches, Order Cockles, Family Cockles, and the genus Clams. They are mainly distributed along the coasts of China, Korea and Japan. Warm in nature and sweet in taste, it has the effects of nourishing blood and invigorating the stomach. "Compendium of Materia Medica" records: "wax, sweet and warm, and non-toxic in nature, sweet and warm can benefit qi and nourish the middle, then the five internal organs will be safe, stomach qi will be strong, confidantes, waist and spine will be afflicted by wind and cold, and if the stomach is healthy, food will disappear. If the viscera is warm, the yang will rise, and if the qi is full, the blood will flow." However, the effect of promoting uterine contraction...

Claims

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Application Information

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IPC IPC(8): A61K35/618A61K9/19A61P15/04A61P15/00
Inventor 石振艳刘坤高华张克凌
Owner QINGDAO UNIV
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