Traditional Chinese medicine composition with antitumor activity and preparation method and application thereof
A technology of anti-tumor activity and composition, which is applied in the field of medicine, can solve the problems of large drug dosage and many impurities, and achieve the effects of low toxic and side effects, scientific and reasonable proportioning, and fast absorption
Active Publication Date: 2018-05-01
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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However, the currently reported antineoplastic drugs have a large dosage and many impurities.
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[0036] 2. the preparation method of the Chinese medicine composition with antitumor activity of the present invention, it may further comprise the steps:
[0037] (1) Take 12 grams of heterophylla, 10 grams of Ophiopogon japonicus, 20 grams of Hedyotis diffusa, 10 grams of August Zha by weight, add ethanol with 12 times the volume of the total medicinal materials, and ultrasonically extract 3 times, each time 2 hours, combine the extracts, concentrate under reduced pressure at 50-80 degrees Celsius, and get the concentrate on a D101 macroporous adsorption resin column, first elute with water, and then use volume concentrations of 20%, 30%, 40%, and 50% and 60% ethanol elution; collect 50% and 60% ethanol eluate, and concentrate to obtain the extract;
[0038] (2) Get 3 grams of centipede, add 8 times the volume concentration of the total medicinal material weight and be 30% ethanol, continuously reflux extraction for 2 times, each time for 3 hours, combine the extracts, and co...
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The invention discloses a traditional Chinese medicine composition with antitumor activity, its preparation method and its application. The traditional Chinese medicine composition comprises 12-36 parts of Radix Pseudostellariae, 10-30 parts of Ophiopogon japonicus, 20-60 parts of Hedyotis diffusa, Made from 10-30 parts of silkworm, 3-9 parts of centipede, and 10-30 parts of August leaves. Pharmacological experiments and clinical experiments show that the traditional Chinese medicine composition with anti-tumor activity provided by the invention has a scientific and reasonable proportion, has the effects of anti-cancer and detoxification, phlegm and blood stasis, and nourishing qi and yin. It has a strong killing effect and a wide range of applications; it can also regulate the content of cAMP in the body and promote the production of tumor necrosis factor (INF), play a multi-target, multi-organ role in the treatment of tumors, prolong the survival period, improve the quality of life of patients, and High safety, low toxicity and side effects. The preparation method provided by the invention has stable quality, high content of extracted active ingredients, strong operability, and is suitable for large-scale industrial production.
Description
technical field [0001] The invention relates to a medicine, in particular to a traditional Chinese medicine composition with antitumor activity and its preparation method and application. Background technique [0002] Tumor has become the number one killer threatening human survival in the 21st century, with an average of more than 6 million people dying of various tumor diseases every year. China is one of the countries with high incidence of cancer in the world, and it shows a rapid growth trend every year. Clinically, the current drugs for treating tumors mainly include chemical drugs. However, due to the high toxicity of chemotherapy drugs, they can not selectively kill white blood cells, lymphocytes and other human immune cells while killing tumor cells. As a result, patients often suffer from autoimmune diseases. Complicated infection due to low ability, severe adverse reactions in patients, long course of treatment, high cost, and great limitations in clinical use. ...
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IPC IPC(8): A61K36/8968A61P35/00A61K35/64A61K35/648
Inventor 程海波周仲瑛沈卫星李柳孙东东徐长亮谭佳妮沈政洁吴东东
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE