Liquid chromatograph and column oven for use therein

Abstract

A liquid leakage decision unit includes a leak sensor value storage part that stores a leak sensor value that is based on the intensity of a signal received from a gas sensor; a difference calculation part that, when the signal is received from the gas sensor, calculates, as a difference value, a value obtained by subtracting a previous leak sensor value stored in the leak sensor value storage part from a current leak sensor value; and a liquid leakage detection part that compares the difference value calculated by the difference calculation part with a preset threshold, thereby to detect liquid leakage in the column oven.

Description

technical field [0001] The present invention relates to a liquid chromatograph including a high-speed liquid chromatograph, and a column oven used therein. Background technique [0002] Separation analysis was performed while keeping the temperature of the separation column constant in the liquid chromatograph. In order to keep the column temperature constant, the separation column was housed in a column oven. In the column oven, in order to keep the temperature of the column oven constant, a temperature adjustment mechanism is provided. As the temperature adjustment mechanism, for example, a block heater is provided as a heat source, and an air circulation method is adopted to circulate the heat in the column. [0003] Volatile solvents such as methanol, acetonitrile, and isopropanol (IPA) are used as mobile phases in liquid chromatography. Furthermore, in the column oven, the separation column is connected to the analysis flow path through a joint, and the mobile phase ...

AI Technical Summary

Problems solved by technology

[0006] As described above, in a system that monitors a leak sensor value based on the output of a gas sensor, compares the leak sensor value with a leak threshold, and thereby detects a leak of a mobile phase solvent, it is known that the following problem may occur. If the column thermostat runs continuously for a long time, although there is no leakage of the mobile phase solvent, the leakage is detected by mistake

In addition, since the sensitivity of the gas sensor is dependent on temperature and humidity, the temperature and humidity around the gas sensor change over time, and the value of the leak sensor also changes, which is also considered to be a cause of false detection of liquid leakage.

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