Preparation method and application of Shenqi Wuweizi capsules

A technology of Shenqi Schisandra chinensis and Nan Schisandra chinensis is applied in the field of traditional Chinese medicine preparations, which can solve the problems of large dosage for patients, many impurities, rough process and the like, and achieve the effect of reducing the dosage.

Inactive Publication Date: 2015-09-09
NANJING HUAKUANG INFORMATION CONSULTING CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Shenqi Schisandra Capsules. However, methods such as alcohol extraction are used. The process is rough, complicated, backward, and there are many impurities, which leads to excessive dosage for patients, which is inconvenient to take and serious. Affected the clinical application of this product

Method used

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  • Preparation method and application of Shenqi Wuweizi capsules

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: Get 180g of Schisandra chinensis, 60g of Codonopsis pilosula, 120g of Astragalus membranaceus, 30g of fried jujube seed, join in CO2 supercritical extractor, ethanol is used as entrainer, and entrainer accounts for 4% by volume of total extraction solvent, extraction pressure 30MPa , temperature 30°C, CO2 flow rate 1m1 / g crude drug·min, extraction time 180min, supercritical extract was obtained, crushed, added 20g of starch, 70% ethanol to make granules, dried, packed into capsules, made into 800 capsules, each weighing 0.3 g.

Embodiment 2

[0016] Embodiment 2: Get 180g of Schisandra chinensis, 60g of Codonopsis pilosula, 120g of Astragalus membranaceus, 30g of fried jujube seeds, join in CO2 supercritical extractor, ethanol is used as entrainer, and entrainer accounts for 6% by volume of total extraction solvent, extraction pressure 15MPa , temperature 50°C, CO2 flow rate 1m1 / g crude drug·min, extraction time 180min, supercritical extract was obtained, crushed, added 20g starch, 70% ethanol to make granules, dried, packed into capsules, made into 800 capsules, each weighing 0.3 g.

Embodiment 3

[0017] Embodiment 3: Get 180g of Schisandra chinensis, 60g of Codonopsis pilosula, 120g of Astragalus membranaceus, 30g of fried jujube seeds, join in CO2 supercritical extractor, ethanol is used as entrainer, and entrainer accounts for 5% by volume of total extraction solvent, extraction pressure 20MPa , temperature 40°C, CO2 flow rate 2m1 / g crude drug·min, extraction time 160min, supercritical extract was obtained, crushed, added 20g starch, 70% ethanol to make granules, dried, packed into capsules, made into 800 capsules, each weighing 0.3 g.

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Abstract

The invention belongs to the field of Chinese herba preparation, and particularly provides a preparation method of Shenqi Wuweizi capsules. The Shenqi Wuweizi capsules are prepared by the following bulk drugs: 180g of kadsura longepedunculata, 60g of roots of hairy asiabell, 120g of astragalus membranaceus and 30g of semen ziziphi spinosae in a supercritical fluid extraction; the content is greatly improved; and the using level of the bulk drugs is reduced. The invention also provides an application of the Shenqi Wuweizi capsules on preparation of medicines for restraining proliferation of epithelial cells D407 of human retinochrome.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Shenqi Wuweizi capsules. Background technique [0002] Shenqi Wuweizi Capsules are recorded in the standards of the State Drug and Food Administration. The prescription is 180g of Southern Schisandra, 60g of Codonopsis, 120g of Astragalus, and 30g of fried Suanzaoren. Use 45% ethanol, 70% ethanol, and 60% ethanol as solvents for the fried jujube kernels and the remaining schisandra chinensis, respectively, and soak for 24 hours, then percolate, collect the percolation liquid, recover the ethanol, combine, concentrate to an appropriate amount, add the above fine powder and Appropriate amount of auxiliary materials, mixed evenly, made into granules, and filled into capsules to obtain 1000 granules, each 0.3g. It has the functions of invigorating the spleen and replenishing qi, calming the mind and calming th...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/725A61K9/48A61P35/00
Inventor 李洋
Owner NANJING HUAKUANG INFORMATION CONSULTING CENT
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