Preparation method and application of a traditional Chinese medicine ointment for preventing and treating delayed nausea and vomiting caused by chemotherapy

Abstract

The invention discloses a preparation method of a traditional Chinese medicine ointment for preventing and treating delayed nausea and vomiting caused by chemotherapy. The preparation method comprises the steps that raw materials are smashed; smashed amomum villosum is fetched for extracting amomum villosum volatile oil by a steam distillation method; fresh ginger is juiced to obtain ginger juice; and smashed pinellia rhizoma prepared by ginger, cassia twigs, agastache rugosus, fructus evodiae, inula flower, pericarpium citri reticulatae, ligusticum wallichii, menthol, folia perillae acutae, endothelium corneum gigeriae galli, sea-buckthorn, the amomum villosum volatile oil and the ginger juice are evenly mixed and added with honey to be stirred in a paste shape, and the traditional Chinese medicine ointment is obtained. The preparation method has the advantages that the composition is rigorous, preparation is easy, irritation is avoided, the price is low, operation is simple and convenient, the ointment can be accepted by patients easily, and the ointment has a wide clinical application prospect. The invention further discloses application of the traditional Chinese medicine ointment for treating delayed nausea and vomiting combined with granisetron and dexamethasone. The traditional Chinese medicine ointment can well treat delayed nausea and vomiting and inappetence caused by cis-platinum, also can relieve the side effects, like constipation of patient, caused by the usage of the granisetron and dexamethasone, has good compliance, and reaches the international leading level.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition, in particular to a preparation method of a traditional Chinese medicinal ointment for preventing and treating delayed nausea and vomiting caused by chemotherapy. Background technique [0002] Delayed nausea and vomiting is vomiting that occurs 24 hours after chemotherapy. Usually occurs 48-72 hours, sometimes up to 120 hours later. Delayed nausea and vomiting occurred in 19%-33% and 49%-75% of patients receiving moderate- and high-emetic-risk chemotherapy, respectively. Cisplatin is a broad-spectrum antineoplastic drug widely used clinically at present, and has a high risk of causing emesis, and 70-80% of patients will experience delayed nausea and vomiting. At present, there is a lack of effective anti-vomiting drugs clinically, and the control rate of delayed nausea and vomiting for the first-generation 5-HT3 receptor antagonist is about 28%; the second-gen...

AI Technical Summary

Problems solved by technology

At present, there is a lack of effective anti-vomiting drugs clinically, and the control rate of delayed nausea and vomiting for the first-generation 5-HT3 receptor antagonist is about 28%; the second-generation 5-HT3 receptor antagonist palonosetron and The combined use of dexamethasone has been confirmed by a large number of studies to reduce the incidence of delayed nausea and vomiting. The control rate of delayed nausea and vomiting is 35%-41%, and the incidence of treatment-related adverse reactions is 44%.

The curative effect of continuous medication of 5-HT3 receptor antagonists is not ideal, and its adverse reactions such as constipation and abdominal distension make it difficult for patients to adhere to continuous medication

Glucocorticoids are commonly used drugs in clinical practice. Combined with 5-HT3 receptor antagonists and NK-1 antagonists, they can significantly improve the control rate of chemotherapy nausea and vomiting, and play a role in synergizing the efficacy and raising the emetic threshold. The research of Roscoe et al. further confirmed that Adding dexamethasone to conventional antiemetic treatment can significantly increase the control rate of delayed nausea and vomiting, but dexamethasone often causes moderate to severe insomnia, dyspepsia, upper abdominal discomfort, restlessness, increased appetite, elevated blood sugar, weight gain and Acne and other adverse reactions

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