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A pharmaceutical composition for treating malignant pleural effusion, its preparation method and application

A malignant pleural effusion and composition technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of excessive drugs, scattered prescriptions and unclear main lines, etc., and achieve improvement Quality of life, strong pertinence, and the effect of improving clinical symptoms

Active Publication Date: 2018-08-28
花宝金
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the patent document 201010284152.0, the power of warming the yang is also insufficient, and the focus is on the regression of pleural effusion and the reduction of adverse reactions. The prescriptions are scattered, there are too many drugs, and the main line is unclear, so it is difficult to play an effective therapeutic role.
The flaws in the prescription of the above-mentioned patented technology determine that it is difficult to produce good clinical effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1: Preparation of the pharmaceutical composition of the present invention 1

[0064] Combine 5 parts of American ginseng, 20 parts of Panax notoginseng, 5 parts of Tinglizi, 18 parts of Shiwei, 8 parts of Jiaomu, 40 parts of Xu Changqing, 25 parts of Gualou, 40 parts of Astragalus, 15 parts of Alisma orientalis, 8 parts of Baizhu 3 servings, decocted twice with water, added 8 and 6 times the amount of water respectively, decocted for 3 and 1.5 hours respectively, combined the decoction, filtered, and concentrated to an extract with a relative density of 1.10 (60℃) And spray drying to obtain a pharmaceutical composition.

Embodiment 2

[0065] Example 2 Preparation of the pharmaceutical composition of the present invention 2

[0066] Combine 15 parts of American ginseng, 8 parts of Panax notoginseng, 15 parts of Tinglizi, 6 parts of Shiwei, 6 parts of Jiaomu, 20 parts of Xu Changqing, 20 parts of Gualou, 20 parts of Astragalus, 5 parts of Alisma, 18 parts of Baizhu, Chinese date 9 parts, decocted 3 times with water, added 10, 6, and 6 times the amount of water, respectively, the decocted time was 1.5, 1.5, 2 hours, combined the decoction, filtered, and concentrated to a relative density of 1.10 (60℃ ) Is spray-dried to obtain a pharmaceutical composition.

Embodiment 3

[0067] Example 3: Tablets for treating malignant pleural effusion

[0068] Take 10g of American ginseng, 12g of Panax notoginseng, 10g of Tinglizi, 12g of Shiwei, 5g of Jiaomu, 30g of Xu Changqing, 15g of Trichosanthis, 30g of Raw Astragalus, 10g of Alisma, 12g of Atractylodes macrocephala, 6g of Jujube, decocted 3 times with The amount of water is 8, 6, and 6 times the amount of water, and the cooking time is 2, 1.5, and 1.5 hours respectively. Combine the decoction, filter, and concentrate to an extract with a relative density of 1.10 (60℃). Add 30% of the microcrystalline cellulose and 45% of lactose by weight of the extract powder, mix them evenly, and press tablets.

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PUM

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Abstract

The invention provides a medicine composite for treating malignant pleural effusion. The medicine composite is prepared with, by weight, 2-18 parts of American ginseng, 4-30 parts of pseudo-ginseng, 2-18 parts of pepperweed seeds, 3-21 parts of pyrrosia lingua, 2-8 parts of seeds of zanthoxylom bungeanum maxim, 10-50 parts of cynanchum paniculatum, 5-25 parts of snake gourd fruits, 10-50 parts of raw radix astragalis, 2-18 parts of rhizoma alismatis, 3-21 parts of rhizoma atractylodis macrocephalae and 2-12 parts of Chinese dates. All ingredients cooperate with one another, the medicine composite is placed in water for dissolution before drinking and is effective in warming the Yang, smoothing the Qi, communicating the Yang and the Qi, excreting the dampness and tonifying the spleen, and all medicine cooperate to achieve that the Yang is warmed and the effusion is relieved. Clinical tests prove that the medicine composite is capable of effectively treating the malignant pleural effusion.

Description

Technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating malignant pleural effusion and a preparation method thereof. Background technique [0002] Malignant pleural effusion refers to pleural effusion caused by lung cancer or other malignant tumors involving the pleura or primary tumors of the pleura. Except for primary brain tumors and extremity tumors, almost all malignant tumors can cause malignant pleural effusion. Among them, lung cancer is the most common, breast cancer ranks second, and lymphoma again, about 5%-10% of malignant pleural effusions The fluid could not find the primary tumor. [0003] Malignant pleural effusion is one of the common complications of advanced tumors, most of which are the result of disease progression or recurrence. It can also be the first clinical manifestation of tumor patients, which seriously affects the survival time and quality of life of patients. A large amo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P7/10A61K35/57
Inventor 花宝金施展郑红刚李丛煌鲍艳举刘瑞秦英刚
Owner 花宝金
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