Tilmicosin and ceftiofur injection and preparing equipment and process

A technology of tilmicosin and ceftiofur, which is used in drug delivery, antibacterial drugs, respiratory diseases, etc., can solve the problems of sepsis, respiratory tract infection, systemic, economic loss, etc., and achieves long half-life, good preparation stability, The effect of reducing the dilution rate

Inactive Publication Date: 2015-10-07
侯强红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Then secondary infection of Pasteurella, Streptococcus, Actinobacillus pleuropneumoniae, causing severe respiratory infection to systemic sepsis, resulting in significant economic losses

Method used

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  • Tilmicosin and ceftiofur injection and preparing equipment and process
  • Tilmicosin and ceftiofur injection and preparing equipment and process
  • Tilmicosin and ceftiofur injection and preparing equipment and process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A kind of tilmicosin and ceftiofur injection, the injection of 1000ml contains the tilmicosin of 50g, the ceftiofur sodium of 50g, the aluminum stearate of 5g, the vitamin C of 10g, the balance is large soybean oil.

[0044] Use the following processing steps

[0045] 1) Preparation of sterilized soybean oil, the soybean oil for injection is filtered through a filter device, sealed and transferred to a dry heat sterilization device, heated to 160°C for sterilization, and then taken out and placed in a cooling device and cooled to 80°C to obtain Sterilized soybean oil;

[0046] 2) For the preparation of 10% aluminum stearate oil gel, take the injected soybean oil and aluminum stearate and put them into a mixing and dissolving device to fully dissolve them, and heat them to 120°C in a heating device to obtain 10% stearic acid Aluminum oil glue;

[0047] 3) Dilute, use the sterilized soybean oil prepared in step 1) to dilute the 10% aluminum stearate oil gel prepared in...

Embodiment 2

[0053] A kind of tilmicosin and ceftiofur injection, the injection of 1000ml contains 100g of tilmicosin, 20g of ceftiofur sodium, 15g of aluminum stearate, 10g of vitamin C, and the balance is large soybean oil.

[0054] Use the following processing steps

[0055] 1) The preparation of sterilized soybean oil, the soybean oil for injection is filtered through a filter device, sealed and transferred to a dry heat sterilization device, heated to 170°C for sterilization, and then taken out and placed in a cooling device to cool to 60°C to obtain Sterilized soybean oil;

[0056] 2) For the preparation of 10% aluminum stearate oil gel, take the injected soybean oil and aluminum stearate and put them into a mixing and dissolving device to fully dissolve them, and heat them to 120°C in a heating device to obtain 10% stearic acid Aluminum oil glue;

[0057] 3) Dilute, use the sterilized soybean oil prepared in step 1) to dilute the 10% aluminum stearate oil gel prepared in step 2) ...

Embodiment 3

[0063] A kind of tilmicosin and ceftiofur injection, the injection of 1000ml contains 80g of tilmicosin, 35g of ceftiofur sodium, 10g of aluminum stearate, 10g of vitamin C, and the balance is large soybean oil.

[0064] Use the following processing steps

[0065] 1) The preparation of sterilized soybean oil, the soybean oil for injection is filtered through a filter device, sealed and transferred to a dry heat sterilization device, heated to 165°C for sterilization, and then taken out and placed in a cooling device and cooled to 70°C to obtain Sterilized soybean oil;

[0066] 2) For the preparation of 10% aluminum stearate oil gel, take the injected soybean oil and aluminum stearate and put them into a mixing and dissolving device to fully dissolve them, and heat them to 120°C in a heating device to obtain 10% stearic acid Aluminum oil glue;

[0067] 3) Dilute, use the sterilized soybean oil prepared in step 1) to dilute the 10% aluminum stearate oil gel prepared in step 2...

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Abstract

The invention relates to the field of veterinary medicine, in particular to a tilmicosin and ceftiofur injection and preparing equipment and process. The tilmicosin and ceftiofur injection contains tilmicosin, ceftiofur, aluminum stearate, vitamin C and soybean oil; the preparing equipment comprises a soybean oil storing tank, a filtering device, a mixing and dissolving device, a dry heat sterilizing device, a cooling device, a heating device, a diluting device, a mixing and stirring device, a high-pressure homogenizing device, a stirring and subpackaging device and sterilizing device; the preparing process includes the steps of preparation of sterilizing soybean oil, preparation of aluminum stearate factice of 10%, dilution, mixing and stirring, homogenizing and mixing, stirring and subpackaging and sterilizing. Through the specific preparing equipment and the excellent preparing process, tilmicosin and ceftiofur are prepared to be the oil suspension injection, so that ceftiofur and tilmicosin can be combined for administration to treat respiratory infectious diseases and systemic sepsis caused by mycoplasma secondary infection gram-positive bacteria and gram-negative bacteria infection.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a tilmicosin and ceftiofur injection, processing equipment and a process. Background technique [0002] Ceftiofur is a third-generation cephalosporin specially used for animals. It is a semi-synthetic broad-spectrum antibiotic commonly used in veterinary clinics. It can be used to treat infections such as Pasteurella multocida and hemolytic, Escherichia coli, Salmonella, streptococcus, and staphylococcus, and its effect on streptococci is stronger than that of fluoroquinolones. Tilmicosin is also a special antibiotic for livestock and poultry, and has inhibitory effects on Gram-positive bacteria, a small number of Gram-negative bacteria, mycoplasma, and spirochetes. Especially Actinobacillus pleuropneumoniae, Pasteurella and Mycoplasma have strong antibacterial activity. In veterinary clinics, porcine respiratory infectious diseases usually start from mycoplasma infection, an...

Claims

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Application Information

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IPC IPC(8): A61K31/706A61K9/08A61P31/04A61P11/00A61P11/06A61K31/546
Inventor 侯强红李进军李辉舒鸣王湘
Owner 侯强红
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