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Application of cyclocarya paliurus effective part in preparation of medicine used for treating non-alcoholic fatty liver disease

An effective part, non-alcoholic technology, applied in the field of pharmacy, can solve the problems of limited use, aggravated liver burden, poor drug efficacy, etc.

Inactive Publication Date: 2015-10-14
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, non-alcoholic fatty liver is often treated by increasing insulin sensitivity, improving insulin resistance (such as biguanides, thiazolidinediones), reducing blood lipids (statins, fibrates), and anti-oxidation (vitamin E). The drug may have side effects, or increase the burden on the liver, or the drug is not effective, and its use is restricted
There are currently no approved drugs for the treatment of NAFLD

Method used

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  • Application of cyclocarya paliurus effective part in preparation of medicine used for treating non-alcoholic fatty liver disease
  • Application of cyclocarya paliurus effective part in preparation of medicine used for treating non-alcoholic fatty liver disease
  • Application of cyclocarya paliurus effective part in preparation of medicine used for treating non-alcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of effective parts of Cyclocarya paliurus

[0025] 1. Preparation of effective parts of Cyclocarya paliurus

[0026] 1 kg of dried leaves of Cyclocarya paliurus, 80% (volume / volume) ethanol 8L reflux extraction 3 times, 2 hours each time, combined extracts, filtered, recovered solvent to obtain extract. Suspend the extract by adding an appropriate amount of water, extract three times with 1.5 times the amount of chloroform, and recover the solvent to obtain Cyclocarya paliurus extract. Wherein the percentage content of triterpenes is 10%-80% (weight / weight).

[0027] 2. Determination of total triterpene content:

[0028] Preparation of standard product: Accurately weigh 5 mg of oleanolic acid standard product, and prepare a mother solution with a concentration of 0.1 mg / mL with absolute ethanol. Then take 1.0-5.0 mL of the mother liquor, and dilute to 10 mL with absolute ethanol. Take 1 mL each of the above-mentioned diluted reference solution...

Embodiment 2

[0032] Example 2: Improvement effect of effective parts of Cyclocarya paliurus on NAFLD

[0033] 1. Materials

[0034] 1.1 Animals

[0035] Healthy male SD rats, 180-220 g, SPF grade, were purchased from the Experimental Animal Center of Nantong University, license number: SCXK (SU 12014-000).

[0036] 1.2 Drugs and reagents

[0037] The powder of the active part of Cyclocarya paliurus is dissolved in an appropriate amount of 0.5% sodium carboxymethylcellulose solution, and a solution with a certain concentration is prepared for use. Simvastatin was purchased from Yichang Changsha Pharmaceutical Co., Ltd. Triglyceride (TG), total cholesterol (TC), non-esterified fatty acids (NEFAs), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), malondialdehyde (MDA) detection reagents The box was purchased from Nanjing Jiancheng Institute of Bioengineering. Rat TNF-α Elisa kit was purchased from Nanjing Senbega Biotechnology Co., Ltd.

[00...

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Abstract

The invention belongs to the field of pharmaceuticals and relates to application of a cyclocarya paliurus effective part in preparation of health products and medicines which are used for treating a non-alcoholic fatty liver disease. The cyclocarya paliurus effective part mainly contains natural triterpenoid and can be used for effectively reducing rat liver lipid accumulation degree and triglyceride level which are caused by high fat diet, improving the liver histology and liver functions and improving the liver oxidative stress and the organism inflammatory level, so that the cyclocarya paliurus effective part can be used for obviously alleviating non-alcoholic fatty liver disease and preparing health products and medicines which are used for treating the non-alcohol fatty liver disease. The application of the cyclocarya paliurus effective part has the advantage that application range of cyclocarya paliurus preparation in the medical field.

Description

technical field [0001] The present invention relates to the new application of the Cyclocarya paliurana extract and its effective parts, in particular to the new application of the Cyclocarya paliurus effective part in the field of pharmacy, specifically the application in the preparation of medicines for preventing and treating non-alcoholic fatty liver. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome characterized by fatty degeneration and fat accumulation in hepatic parenchymal cells without a history of excessive alcohol consumption. It is by far the most common chronic liver disease. Its basic course includes simple fatty liver, steatohepatitis, fatty liver fibrosis, and may eventually develop into fatty liver cirrhosis and fatty liver cancer, which may lead to premature death. There are about 20-40% of NAFLD patients in the world, and the number is increasing and showing a trend of younger age. NAFLD is the liver's respo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A23L1/29A61P1/16
Inventor 殷志琦林孜吴正凤操兰洁
Owner CHINA PHARM UNIV
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