Pharmaceutical composition containing enalapril and preparation method thereof

Abstract

The invention relates to a pharmaceutical composition containing enalapril and a preparation method thereof. The solid pharmaceutical composition is composed of enalapril / pharmaceutically-acceptable salts of enalapril and silica. A liquid diluent is added into the solid pharmaceutical composition before application; then the mixture is shaken to evenly mix the composition and the diluent; and thus the solid pharmaceutical composition is converted into a liquid pharmaceutical composition; wherein the liquid diluent is selected from but not limited to the following components: water, syrup, fruit juice, beverage, suspension, emulsion, or composition thereof. The provided solid pharmaceutical composition containing enalapril has a good stability and long shelf life, at the same time the fluidity problem of materials is well solved, and the solid pharmaceutical composition is suitable for the mechanical massive production. Moreover, the reconstructed liquid pharmaceutical composition prepared from the solid pharmaceutical composition also has a good stability and long shelf life, and thus the risk during the storage process of preparation is reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing enalapril and a preparation method thereof. Background technique [0002] With the development of society and the improvement of people's living standards, hypertension has become one of the main diseases causing serious health problems in many countries. According to statistics, about one-third of adults in the United States suffer from high blood pressure, and there is an increasing trend year by year. According to incomplete statistics from the World Health Organization, the incidence of cardiovascular disease (CVD) in my country is 1.78% for men and 1.10% for women, and the prevalence rate increases with age. There are about 230 million CVD patients in the country, and every 100 adults 20 people suffer from CVD, and the number of deaths due to it is about 3.5 million in the country every year, and 9,590 people die fr...

AI Technical Summary

Problems solved by technology

Although this patent provides a preparation method for enalapril maleate oral liquid and a solution to ensure the stability of the liquid preparation, it still has disadvantages that cannot be ignored

We know that enalapril maleate itself is quite stable under conditions such as high temperature, high humidity, and strong light, but enalapril maleate preparations are relatively unstable, and the influence of excipients is the key

Although the above-mentioned patent provides a method for preparing enalapril maleate oral liquid, its solid powder packaging can only guarantee the stability of 6 months, and the reconstituted liquid solution can only guarantee the stability of 12 weeks

Images