Single-wall carbon nano tube temperature-sensitive gel and preparation method and application thereof

A technology of single-walled carbon nanotubes and carbon nanotubes, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, antineoplastic drugs, etc.

Inactive Publication Date: 2015-10-21
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there have been many literature reports on the use of pNIPAM glue or CNT alone to treat tumors, but there is still no relevant in vitro and in vivo research on the combination of pNIPAM and CNT to treat gastric cancer.

Method used

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  • Single-wall carbon nano tube temperature-sensitive gel and preparation method and application thereof
  • Single-wall carbon nano tube temperature-sensitive gel and preparation method and application thereof
  • Single-wall carbon nano tube temperature-sensitive gel and preparation method and application thereof

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Embodiment 1

[0030] Embodiment 1: Preparation of single-walled carbon nanotube thermosensitive glue (SWNT-GEL) according to the present invention

[0031] Gelatin / SWNT-APTS was first synthesized, and by combining with NIPAM-NH 2SWNT-GEL was synthesized by copolymerization reaction, and SWNT-GEL was simultaneously used as a medium for carrying anti-tumor drugs and hyperthermia treatment.

[0032] 1. Materials

[0033] All chemical reagents were purchased from Aldrich Chemical Company (St. Louis, MO, USA) and used without further purification (unless otherwise specified). Ethyl(dimethylaminopropyl)carbodiimide (EDC) and N-Hydroxysuccinimide (NHS) were purchased from JenKem Technology USA Inc. (Allen, TX, USA). Dialysis membrane (MWCO = 7kDa MWCO), isopropylacrylamide (NIPAM), cysteamine hydrochloride, 3-Aminopropyl-trimethoxysilan (APTS), Ammonium persulfate, N,N,N',N'-tetramethylethylenediamine (TMED) And gelatin was purchased from ACROS (New Jersey, USA). SWNTs were purchased from US R...

Embodiment 2

[0047] Embodiment two: performance measurement of single-walled carbon nanotube thermosensitive glue (SWNT-GEL) of the present invention

[0048] (1) Transmission electron microscope (TEM) observation of SWNT-GEL

[0049] The SWNT-GEL powder was placed on ice and dissolved in deionized water, suspended and oscillated to obtain a SWNT-GEL suspension with a concentration of 20 mg / ml, which was stored at 4°C. Pipette 2 μl of SWNT-GEL solution onto a copper grid dedicated to TEM for sample preparation and let it stand for fixation. The overall morphology and microstructure of SWNT-GEL were acquired and photographed by Hitachi TEM system (under the condition of voltage 80kV). The image magnification is between 10,000× and 40,000×.

[0050] pNIPAM is a well known temperature sensitive polymer. When the temperature is lower than its lowest critical solution temperature (LCST, 33°C), the nitrogen and oxygen atoms between the intermediate bonds and water molecules form hydrogen bond...

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Abstract

The invention discloses single-wall carbon nano tube temperature-sensitive gel and a preparation method and application of the gel. The single-wall carbon nano tube temperature-sensitive gel (SWNT-GEL) is synthesized through copolymerization reaction of a combination product of gelatin and oxidization single-walled carbon nanotubes (SWNT)-trimethoxy silane (APTS) and pNIPAM-NH2. The single-wall carbon nano tube temperature-sensitive gel is used for preparing an injection medicine delivery system and is used for preparing a light and heat conduction medium. The invention further provides a medicine for treating the cancer. The medicine comprises a medicine carrier prepared by the single-wall carbon nano tube temperature-sensitive gel and a cancer treatment medicine on the medicine carrier. The gel shows the good application prospect of temperature-sensitive hydrogel with the SWNT as the basis as the injection medicine delivery system and an over-high heat treatment medium, and particularly shows the effect of the temperature-sensitive hydrogel in gastric cancer treatment.

Description

technical field [0001] The invention relates to a single-wall carbon nanotube temperature-sensitive adhesive, a preparation method and application of the single-wall carbon nanotube temperature-sensitive adhesive. Background technique [0002] pNIPAM thermosensitive polymer has been widely used in the field of biomedicine, and has no cytotoxicity. Its application relies on the critical solution temperature (CST), i.e., above 33 °C pNIPAM undergoes a sol-gel transition and thus favors hydrogel formation at normothermic conditions (G.ER, L.JC, E.J, Pharm Biopharm 2004, 58, 409.). It has been reported in the literature that as a type of drug carrier, pH-sensitive pNIPAM microgels can transport chemotherapy drugs in vivo and effectively kill tumor cells (Y. Guan, Y. Zhang, Soft Matter 2011, 7, 6375.). At present, many literatures have reported that pNIPAM glue or CNT alone is used to treat tumors, but there is still no relevant in vitro and in vivo research on the combination ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K31/704A61P35/00
Inventor 廖旺军石敏周敏钰林立黄娜邢梦秋
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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