Prediction method for veterinary drug residue concentration in tissue of domestic rabbit
A prediction method and organizational technology, applied in biological testing, material inspection products, special data processing applications, etc., can solve problems such as increasing the risk of veterinary drug residues
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Embodiment 1
[0093] In this example, Obifloxacin was taken as an example to predict the residual concentration of the drug in various tissues of rabbits after a single intramuscular injection. Obifloxacin is a small molecular substance, and during its distribution in animals, the blood flow of various tissues and organs is the main rate-limiting factor, that is, the physiological pharmacokinetic model established in the present invention is a blood flow rate-limiting type. For rabbits, muscle is the most important edible tissue, liver and kidney are the main organs for clearing orbifloxacin, and lung is the intermediate pathway connecting venous blood and arterial blood. In addition to the above tissues and organs, This model combines all other tissues into one virtual compartment of all other tissues. In addition, in order to facilitate the simulation of oral drug delivery, two modules of the stomach and intestinal tract are added to the model. Similarly, in order to facilitate the simulat...
Embodiment 2
[0120] The dosing regimen in Example 1 was changed to: three consecutive intravenous injections, with a dosing interval of 24 hours, and each dosing dose was 10 mg / kgbw. The rest of the conditions and modeling steps were the same as in Example 1. After using the acsl software to build the model, run the model to obtain the curves of the concentration of orbifloxacin in various tissues over time, as shown in Figure 8 and Figure 9 As shown, the concentration of orbifloxacin in muscle, liver, kidney, lung and plasma was predicted after three consecutive intravenous injections of orbifloxacin in rabbits.
Embodiment 3
[0122] The dosing regimen in Example 1 was changed to: three consecutive oral administrations, the dosing interval was 24 hours, and the dosage for each administration was 10 mg / kgbw. The rest of the conditions and modeling steps were the same as in Example 1. After using the acsl software to build the model, run the model to obtain the curves of the concentration of orbifloxacin in each tissue as a function of time, such as Figure 10 and Figure 11 As shown, the predicted concentration of orbifloxacin in kidney, liver, lung, muscle and plasma after three consecutive oral administration of orbifloxacin to rabbits.
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