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Method and composition for inducing autophagy

A technology of inducing cells and cells, which is applied in the fields of pharmaceutical formulations, drug combinations, plant raw materials, etc., and can solve the problem that the characteristics of enhancing intelligence have not been fully studied

Inactive Publication Date: 2015-11-11
吴淑芬 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its intelligence-enhancing properties have not been fully studied

Method used

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  • Method and composition for inducing autophagy
  • Method and composition for inducing autophagy
  • Method and composition for inducing autophagy

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Embodiment Construction

[0036] Various specific details are provided herein to provide a more thorough understanding of the invention.

[0037] In the instructions and drawings, Ganoderma lucidum is abbreviated as GaLu.

[0038] Preparation of samples of Ganoderma lucidum extract

[0039]Dried Ganoderma lucidum (Leyss. ex Fr.) Karst. was soaked in 85% (v / v) alcohol to extract small molecule (molecular weight less than 1000 dalton) fraction. The extract was concentrated in a rotary vacuum evaporator and freeze-dried and stored at -20°C until use. The isolated Ganoderma lucidum small molecule extract was obtained by HPLC. Reverse-phase HPLC analysis was performed at room temperature using a column (Neulcosil C18 column) (250 mm×4.6 mmi.d.5 μm). The mobile phase comprises solution (A) 0.1% acetic acid aqueous solution (v / v) and solution (B) acetonitrile, the linear gradient change program used is: 0 to 40 minutes is 30 to 32% B solution, 40 to 60 minutes is 32 to 40% B solution, 40% B solution for 6...

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Abstract

A method for inducing autophagy in a subject having an autophagy defect is provided. The method of the present invention includes the step of administering to the subject a therapeutically effective amount of a Ganoderma lucidum extract, wherein the autophagy enhances clearance of protein aggregates in the subject.

Description

technical field [0001] The present invention relates to a method for inducing autophagy in individuals suffering from autophagy deficiency, particularly a method for inducing autophagy in individuals suffering from autophagy deficiency by administering Ganoderma lucidum extract to the individual method of devouring. Background technique [0002] Autophagy, or "selfdigestion process", is an important physiological process that targets components in the cytoplasm, such as proteins and protein aggregates to be degraded in lysosomes and organelles. The process of autophagy is also necessary to maintain neural homeostasis, and its dysfunction is directly related to various diseases. [0003] When cells are starved, the purpose of autophagy is to recycle intracellular nutrients to maintain cell metabolism, and when cells are under stress, autophagy can also remove accumulated damaged organelles and proteins. [0004] Defects in autophagy are a major cause of a variety of diseas...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61P25/28A61P25/16A61P25/00
CPCA61K36/074A61P1/04A61P1/16A61P9/00A61P21/00A61P25/00A61P25/14A61P25/16A61P25/20A61P25/28A61P43/00
Inventor 吴荣灿洪琳雅宋惠璟陈俐彣
Owner 吴淑芬
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